ID S1R4S6_9ENTE Unreviewed; 584 AA.
AC S1R4S6;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=Multidrug resistance-like ATP-binding protein mdlA {ECO:0000313|EMBL:ESK62544.1};
GN ORFNames=OMO_00192 {ECO:0000313|EMBL:ESK62544.1};
OS Enterococcus cecorum DSM 20682 = ATCC 43198.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Enterococcaceae;
OC Enterococcus.
OX NCBI_TaxID=1121864 {ECO:0000313|EMBL:ESK62544.1, ECO:0000313|Proteomes:UP000017415};
RN [1] {ECO:0000313|EMBL:ESK62544.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43198 {ECO:0000313|EMBL:ESK62544.1};
RG The Broad Institute Genomics Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Earl A., Russ C., Gilmore M., Surin D., Walker B., Young S., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Enterococcus cecorum DSM 20682 (= ATCC 43198)
RT (Illumina assembly).";
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ESK62544.1}.
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DR EMBL; AHYS01000001; ESK62544.1; -; Genomic_DNA.
DR RefSeq; WP_016251865.1; NZ_KI535313.1.
DR AlphaFoldDB; S1R4S6; -.
DR STRING; 44008.GCA_001318175_00558; -.
DR GeneID; 60871357; -.
DR PATRIC; fig|1121864.4.peg.1727; -.
DR eggNOG; COG1132; Bacteria.
DR HOGENOM; CLU_000604_84_3_9; -.
DR OrthoDB; 9770415at2; -.
DR Proteomes; UP000017415; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd18541; ABC_6TM_TmrB_like; 1.
DR Gene3D; 1.20.1560.10; ABC transporter type 1, transmembrane domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011527; ABC1_TM_dom.
DR InterPro; IPR036640; ABC1_TM_sf.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR039421; Type_1_exporter.
DR PANTHER; PTHR24221; ATP-BINDING CASSETTE SUB-FAMILY B; 1.
DR PANTHER; PTHR24221:SF300; MULTIDRUG RESISTANCE-LIKE ATP-BINDING PROTEIN MDLA; 1.
DR Pfam; PF00664; ABC_membrane; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF90123; ABC transporter transmembrane region; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50929; ABC_TM1F; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000313|EMBL:ESK62544.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000017415};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 56..77
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 130..154
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 160..179
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 243..268
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 280..301
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 584 AA; 65967 MW; 158892BD09A63ABD CRC64;
MAIFKKLWWF FKQEKKHYLI GITALIVVAL VQLIPPWVIG KVIDEIASKQ IDLQKIFYYI
GLLVFSAISQ YAFRYVWRTN IWGSAARLEK ILRERLFDHF TLMDQIFYHK YRTGDLMAYA
TMNLNAIQNV AGAGILTFID SFITGGITII AMMIFVDIRL TILALLPLPL LSLMAKVLGD
KLHNAFRKSQ DAFSDLNDKV QESVTGIKVI KTFGQEKEDV EDFKDKVDFV IEKNKKVALY
DSLYDPLITL IIGLTYVVTI IIGGGYVVKG TISIGQLVSF MSYIGMLVWP MFAVGQLFNV
LERGNASYDR VFELFREKSH IIEKQTGISQ KANGDLSIDL DSFTYPDGQN PVLQNIHVTI
PQGKTLGIVG KTGSGKTTLL SLLLRTYDDY QGSIYFGDYS IKDYRLDAYL PAIGYVPQDH
FLFSTTIAEN ICFANPNFGE EKMIQAAKQA AIHEDIMQMP HGYETLVGER GISLSGGQKQ
RISIARAFIT DPNLLILDDA LSAVDAKTEE AILEQIRQKE NHSSMIIVAH RLSSVMHADE
IIVLEDGQIA ERGTHQQLLD NQAWYAKMWH KQQLESNLDQ RGAE
//
