ID   S1R721_9ENTE            Unreviewed;       696 AA.
AC   S1R721;
DT   18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT   18-SEP-2013, sequence version 1.
DT   27-MAR-2024, entry version 45.
DE   RecName: Full=Sialidase {ECO:0008006|Google:ProtNLM};
GN   ORFNames=OMO_01700 {ECO:0000313|EMBL:ESK61008.1};
OS   Enterococcus cecorum DSM 20682 = ATCC 43198.
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Enterococcaceae;
OC   Enterococcus.
OX   NCBI_TaxID=1121864 {ECO:0000313|EMBL:ESK61008.1, ECO:0000313|Proteomes:UP000017415};
RN   [1] {ECO:0000313|EMBL:ESK61008.1, ECO:0000313|Proteomes:UP000017415}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43198 {ECO:0000313|EMBL:ESK61008.1,
RC   ECO:0000313|Proteomes:UP000017415};
RG   The Broad Institute Genomics Platform;
RG   The Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Earl A., Russ C., Gilmore M., Surin D., Walker B., Young S., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Enterococcus cecorum DSM 20682 (= ATCC 43198)
RT   (Illumina assembly).";
RL   Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 33 family.
CC       {ECO:0000256|ARBA:ARBA00009348}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ESK61008.1}.
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DR   EMBL; AHYS01000007; ESK61008.1; -; Genomic_DNA.
DR   RefSeq; WP_016250561.1; NZ_KI535313.1.
DR   AlphaFoldDB; S1R721; -.
DR   STRING; 44008.GCA_001318175_01363; -.
DR   GeneID; 60872820; -.
DR   PATRIC; fig|1121864.4.peg.361; -.
DR   eggNOG; COG4409; Bacteria.
DR   HOGENOM; CLU_024974_0_0_9; -.
DR   OrthoDB; 7294637at2; -.
DR   Proteomes; UP000017415; Unassembled WGS sequence.
DR   GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   CDD; cd15482; Sialidase_non-viral; 1.
DR   Gene3D; 2.120.10.10; -; 1.
DR   Gene3D; 2.60.120.200; -; 1.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR004124; Glyco_hydro_33_N.
DR   InterPro; IPR011040; Sialidase.
DR   InterPro; IPR026856; Sialidase_fam.
DR   InterPro; IPR036278; Sialidase_sf.
DR   InterPro; IPR023364; Trans_sialidase_dom3.
DR   PANTHER; PTHR10628; SIALIDASE; 1.
DR   PANTHER; PTHR10628:SF19; SIALIDASE; 1.
DR   Pfam; PF13088; BNR_2; 1.
DR   Pfam; PF02973; Sialidase; 1.
DR   SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR   SUPFAM; SSF50939; Sialidases; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000017415}.
FT   DOMAIN          44..223
FT                   /note="Glycoside hydrolase family 33 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02973"
FT   DOMAIN          457..660
FT                   /note="Sialidase"
FT                   /evidence="ECO:0000259|Pfam:PF13088"
SQ   SEQUENCE   696 AA;  77559 MW;  4B7D8BBDA7E8824A CRC64;
     MINKIHKFAG VAIISGVLLT GLSYSFVNTD KIVYATSELS PNYQSGPYIL NNTGIDISDQ
     VLNKIQGDNQ SIVLNFESSS PNSLQAIFGI SNSNSGYRNN YFDIFMRNSG EIGVEIRDAQ
     KGVNYLFARP ASLWGIHKGN AVENTVVFTA NATEKTYEMY VDGKCIFSKK VEVFIPINGI
     TGQNNAMIGA VNREGSQAFT MNGKVNQLQI FNRVLTSSEI SEHFSRENKK LIFQSGDTTN
     ANYFRIPTLY TLNNGRVLSS VDARYGGTHD SRSKINIATS YSDDNGLTWS NPIFAMKFND
     YEEQLIEWPR EGNAKNLQIS GSASFIDSAI VQDDKGKVVL LADVMPAGIG NNNANRSDSG
     FKEVNGKYYL KLKKNGESSY QYTVRENGVV YNDSTNQPTN YQVNEKYEVL ENGHPLTVEQ
     YSVKFDANSN LQEYHNGKQV PMNVFYKDSI FKVVPTNYIG MTSSSDSGES WKEFKLLPPF
     LGVNHNATYL SPGQGLALSN KNRLIFATYT SGQLTYLVSD DGGNTFTKRS APVPFTNATA
     EAQMIELREG VIRTFFRTTT GKIAYMTSYD NGDTWSGVSY LDMISQTSYG TQVSVIKYSQ
     KIDGKDAVIL SSPNSTAGRK GGQLWVGLIN ADDSIDWRYH YNVDLPNYGY SYSALTELPN
     QHIGLFFEKY DSWSRNELHL SNVVQYVDLE ITDLLK
//