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Database: UniProt
Entry: S2IY12_MUCC1
LinkDB: S2IY12_MUCC1
Original site: S2IY12_MUCC1 
ID   S2IY12_MUCC1            Unreviewed;       835 AA.
AC   S2IY12;
DT   18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT   18-SEP-2013, sequence version 1.
DT   23-MAY-2018, entry version 16.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=HMPREF1544_10631 {ECO:0000313|EMBL:EPB82646.1};
OS   Mucor circinelloides f. circinelloides (strain 1006PhL) (Mucormycosis
OS   agent) (Calyptromyces circinelloides).
OC   Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC   Mucorales; Mucorineae; Mucoraceae; Mucor.
OX   NCBI_TaxID=1220926 {ECO:0000313|EMBL:EPB82646.1, ECO:0000313|Proteomes:UP000014254};
RN   [1] {ECO:0000313|Proteomes:UP000014254}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1006PhL {ECO:0000313|Proteomes:UP000014254};
RG   The Broad Institute Genomics Platform;
RA   Cuomo C., Earl A., Findley K., Lee S.C., Walker B., Young S., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W.,
RA   Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B.,
RA   Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA   Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C.,
RA   Murphy C., Pearson M., Poon T.W., Priest M., Roberts A., Saif S.,
RA   Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT   "The Genome sequence of Mucor circinelloides f. circinelloides
RT   1006PhL.";
RL   Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; KE124105; EPB82646.1; -; Genomic_DNA.
DR   EnsemblFungi; EPB82646; EPB82646; HMPREF1544_10631.
DR   OrthoDB; EOG092C0YCY; -.
DR   Proteomes; UP000014254; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:proton transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000014254};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000014254};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    426    450       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    471    490       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    549    569       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    581    603       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    649    668       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    743    766       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    772    795       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       94    121       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   835 AA;  95918 MW;  7B778ABB7B04408F CRC64;
     MTNSHTTLFR SEEMSLIQLF IPAEVAHTCI AELGELGKVQ FRDLNPSVNA FQRTFVSEIR
     KLDEMERQCR FFQAQIEKSN IPYRTIEPDV HYSSARTAQE IDDLEESLKD HEVRITQMNS
     SYETLLHRNL QLTELRHVLK ETSVFFEQAE SRNQLHQSDT VNTSATVPLL TSNDDEEEGG
     SSQEETGHIE NLAYVTGVIP REKIQIFERV LWRILRGNLY MNFAEIHDDI IDPTDASKKV
     QKNVFAIFAH GQEVINKIKK ITESMGGTLY TVDDASDKRR EALAEVTSRI KDLDVVLTQT
     KETRQNELLN VADSLNAWFI TVRKEKGIYH TMNLFNYDVN RKCLIAEGWC AKNDTPIVNL
     ALKNAIESSG TNMPSVFTEL ETKRKPPTYH KTNKFTEGFQ NIIDAYGIAR YREVNPGLFT
     IVSFPFLFAI MFGDIGHGFL MFCFALYLVL NEKKLANVKD EIFTMFFSGR YMMLMMGIFS
     IFTGCIYNDI FSLSLNIFKS GFDLPSNYTS FETVEEIPNG NVYAFGFDPA WHGSENFLLF
     SNSYKMKQAI IIGVIHMSFA ICLNVFNHVY YGKSIFVWLE FLPQILFMES VFGYLIFCIM
     YKWSINWWEL DSQGNHIHNP PPNLLNMLIY MFLTPGKVDP QDQLYNGQGT VQLVLILVAL
     VCVPWMWFAK PYYLKVKHEK ERLHTMSESD DPEAAGQSTA VTANDDEEEE EEFEFSEEMI
     HQTIHTIEFC LNCISNTASY LRLWALSLAH AQLSSVLWDM TLKIWFNFTG PIAVAGLVIG
     FAMWFVLTIG ILLCMEGLSA FLHALRLHWV EFDGKFYMGD GVKFEPFSFS ALLAD
//
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