ID S2IZZ8_MUCC1 Unreviewed; 568 AA.
AC S2IZZ8;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=VHS domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=HMPREF1544_09889 {ECO:0000313|EMBL:EPB83356.1};
OS Mucor circinelloides f. circinelloides (strain 1006PhL) (Mucormycosis
OS agent) (Calyptromyces circinelloides).
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC Mucoromycetes; Mucorales; Mucorineae; Mucoraceae; Mucor.
OX NCBI_TaxID=1220926 {ECO:0000313|EMBL:EPB83356.1, ECO:0000313|Proteomes:UP000014254};
RN [1] {ECO:0000313|Proteomes:UP000014254}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1006PhL {ECO:0000313|Proteomes:UP000014254};
RG The Broad Institute Genomics Platform;
RA Cuomo C., Earl A., Findley K., Lee S.C., Walker B., Young S., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome sequence of Mucor circinelloides f. circinelloides 1006PhL.";
RL Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KE124074; EPB83356.1; -; Genomic_DNA.
DR AlphaFoldDB; S2IZZ8; -.
DR STRING; 1220926.S2IZZ8; -.
DR VEuPathDB; FungiDB:HMPREF1544_09889; -.
DR eggNOG; KOG1087; Eukaryota.
DR InParanoid; S2IZZ8; -.
DR OMA; PDNYEPN; -.
DR OrthoDB; 460229at2759; -.
DR Proteomes; UP000014254; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-KW.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0043130; F:ubiquitin binding; IEA:InterPro.
DR GO; GO:0016482; P:cytosolic transport; IEA:UniProt.
DR GO; GO:0016197; P:endosomal transport; IEA:UniProt.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0007034; P:vacuolar transport; IEA:UniProt.
DR CDD; cd16998; VHS_GGA_fungi; 1.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.58.160; -; 1.
DR Gene3D; 1.25.40.90; -; 1.
DR Gene3D; 2.60.40.1230; -; 1.
DR InterPro; IPR008152; Clathrin_a/b/g-adaptin_app_Ig.
DR InterPro; IPR013041; Clathrin_app_Ig-like_sf.
DR InterPro; IPR008942; ENTH_VHS.
DR InterPro; IPR008153; GAE_dom.
DR InterPro; IPR004152; GAT_dom.
DR InterPro; IPR038425; GAT_sf.
DR InterPro; IPR002014; VHS_dom.
DR PANTHER; PTHR47180; ADP-RIBOSYLATION FACTOR-BINDING PROTEIN GGA1-RELATED; 1.
DR PANTHER; PTHR47180:SF1; ADP-RIBOSYLATION FACTOR-BINDING PROTEIN GGA1-RELATED; 1.
DR Pfam; PF02883; Alpha_adaptinC2; 1.
DR Pfam; PF03127; GAT; 1.
DR Pfam; PF00790; VHS; 1.
DR SMART; SM00809; Alpha_adaptinC2; 1.
DR SMART; SM00288; VHS; 1.
DR SUPFAM; SSF49348; Clathrin adaptor appendage domain; 1.
DR SUPFAM; SSF48464; ENTH/VHS domain; 1.
DR SUPFAM; SSF89009; GAT-like domain; 1.
DR PROSITE; PS50180; GAE; 1.
DR PROSITE; PS50909; GAT; 1.
DR PROSITE; PS50179; VHS; 1.
PE 4: Predicted;
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000014254};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 12..148
FT /note="VHS"
FT /evidence="ECO:0000259|PROSITE:PS50179"
FT DOMAIN 175..301
FT /note="GAT"
FT /evidence="ECO:0000259|PROSITE:PS50909"
FT DOMAIN 457..568
FT /note="GAE"
FT /evidence="ECO:0000259|PROSITE:PS50180"
FT REGION 337..449
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 337..404
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 417..449
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 568 AA; 63196 MW; D08B4690BC3571BB CRC64;
MPSTLIAIIE GACSPARYEP ELSLNLEICE MINKKQGSAP REAASAIVKL VNSKNLNQAM
LALTLLDNCV KNCGYPFHLQ IASKEFLNEL VRKFPERPAP FPSPVVQRIL YFIKEWKVAL
TDMSRHKDDL VHIKDMYRLL RFKGYRFPEL RDSSVAALAP SDSLKSAHEL EEEDRVAQSA
KLQELIRRGR PQDLVEANRL MKIMSGFDTR QTPDYSQKFE DELHKIQDKA ILLYEMLETV
KPGEKVDRNE TIMDLKGACA SAQPKIQKMI TEEEDNDKIE NLLTLNDMIN NVMAKFADIK
KGLYDTQYEI SGKPPTQDTN TTEEPKQAIS LIDLDDTPAI SSSTGSASPS NSNNKSALNE
LSDLFGSSSI SSPPASTQQQ QSSTFDLFGT SSPAPQQQQP KKTNDIFDLL GGGIPNNPSP
AVSNSEIASP SISNINVPSQ TRQQQTPSPV FNASQEAQVE SAILVNKNGL LIELQIKNSR
DSVCQIKAYF SNQSTAPMEK LMLRLAAPKS MQIKMEPQSS QIIPPKSDKS VTQGIVLNNP
NKEPLRLRYK VSYEQFGVEM ELTGDYHA
//
