ID   S2J0P4_MUCC1            Unreviewed;      1055 AA.
AC   S2J0P4;
DT   18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT   18-SEP-2013, sequence version 1.
DT   27-MAR-2024, entry version 35.
DE   RecName: Full=PDZ domain-containing protein {ECO:0000259|SMART:SM00228};
GN   ORFNames=HMPREF1544_11578 {ECO:0000313|EMBL:EPB81692.1};
OS   Mucor circinelloides f. circinelloides (strain 1006PhL) (Mucormycosis
OS   agent) (Calyptromyces circinelloides).
OC   Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC   Mucoromycetes; Mucorales; Mucorineae; Mucoraceae; Mucor.
OX   NCBI_TaxID=1220926 {ECO:0000313|EMBL:EPB81692.1, ECO:0000313|Proteomes:UP000014254};
RN   [1] {ECO:0000313|Proteomes:UP000014254}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1006PhL {ECO:0000313|Proteomes:UP000014254};
RG   The Broad Institute Genomics Platform;
RA   Cuomo C., Earl A., Findley K., Lee S.C., Walker B., Young S., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome sequence of Mucor circinelloides f. circinelloides 1006PhL.";
RL   Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the peptidase S1C family.
CC       {ECO:0000256|ARBA:ARBA00010541}.
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DR   EMBL; KE124154; EPB81692.1; -; Genomic_DNA.
DR   AlphaFoldDB; S2J0P4; -.
DR   STRING; 1220926.S2J0P4; -.
DR   VEuPathDB; FungiDB:HMPREF1544_11578; -.
DR   eggNOG; KOG1421; Eukaryota.
DR   InParanoid; S2J0P4; -.
DR   OMA; PRHRLIN; -.
DR   OrthoDB; 1779375at2759; -.
DR   Proteomes; UP000014254; Unassembled WGS sequence.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   CDD; cd00987; PDZ_serine_protease; 1.
DR   Gene3D; 2.30.42.10; -; 3.
DR   Gene3D; 2.40.10.120; -; 1.
DR   Gene3D; 2.40.10.10; Trypsin-like serine proteases; 2.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR025926; PDZ-like_dom.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR   InterPro; IPR001940; Peptidase_S1C.
DR   PANTHER; PTHR46366:SF1; PDZ DOMAIN-CONTAINING PROTEIN C1685.05; 1.
DR   PANTHER; PTHR46366; PRO-APOPTOTIC SERINE PROTEASE NMA111; 1.
DR   Pfam; PF12812; PDZ_1; 1.
DR   Pfam; PF13365; Trypsin_2; 1.
DR   PRINTS; PR00834; PROTEASES2C.
DR   SMART; SM00228; PDZ; 3.
DR   SUPFAM; SSF50156; PDZ domain-like; 3.
DR   SUPFAM; SSF50494; Trypsin-like serine proteases; 2.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000014254}.
FT   DOMAIN          325..401
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|SMART:SM00228"
FT   DOMAIN          784..870
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|SMART:SM00228"
FT   DOMAIN          892..968
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|SMART:SM00228"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          966..1006
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        977..991
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1055 AA;  116745 MW;  4EB09F859A2E2AA0 CRC64;
     MDESQHPLVV STPPLRGPVD SPAPIEAAEA ASNLKAHRGS MSLATTQYEQ QAPIDSRILR
     GRSKSLAFGM QAFRPPVDYI APVTTSGVPY KARSWEPTLE KAIRAIVSIK ASHVRSFDTE
     TSGGYTATGF IVDAARGIIL TNRHVVSPAP IVAQAVLTNY EEVDLKPVYR DPVHDFGFMQ
     FDPSRIKFME LEEIKLSPER AKVGLDIRVV GNDAGEKLSI LAGTLARLDR RAPEYGVGEY
     NDFNTFYLQA ASGTSGGSSG SPVLDIDGHA VALNAGGASR ASSSYYLPLD RVQRALTFIQ
     KGMQVPRGTL QTEFEYLPYN EVRRLGLKAH IEEKVRHKFP EETGMLVVRS LLPKGPADNV
     LVPGDIIIGC NGKMVPHFIA LFEILDDSVD QEISLTVSRG KKVQEVKVTV QDLHSITPNR
     FVEIGGGVVH ELSYQLAKSY SQPTGGVYVA TSGHMLASAS AWRKSIIVSV NNIPTPNLDA
     FIEAMKTLAD GARVPVRFYA LHKAYKDKVM IMHVDRHWHK FRIAVRNDFT GLWDFTEMPP
     PPATIPYSPS TATFPPLDSS LALAEKLMPS FVAIDFYLPY LVDGMKATQF YGTGFIVSTN
     PPLIVCDRDT IPIGLGDIFI TFANSIIIPG RLLFLHPFYN YVILTYDPKL IGDTPVKPLE
     FSEKELNQGD EINFIGIGND HSVVMKKTTV SSVSNIGTRE CSPPRWRAMN VEGIKIDDSL
     NSQGGLITND EGQVQALWIS YSSQSEKGKD ISFMSGLLSS LVKPTVDKFL QSGDKVVFKG
     LDAELWTMRI AAARTLGLSD EWVKKIEESG STRHTLLYVL NILDERSACA KVLNVGDVIL
     SVDGKLVTRM SHMMLVHEKD NIDMVILRDG KELNVNVPMS EFSSYETTRV IGWQGALIQR
     PYKAVLEQVR NVPAGVYVSC TLYGSPASNV LRPGVWIVEV QGKPVKDLDS FLQVVHAHEL
     EMGRRRRPSY IPPVQRSAEE KARRESEQND NDALIPDIID EDDDDDNDEG YIRIKTVSRN
     ETVRVVAVKL DLHYWDSWQL VHDEKSVSGW TSESA
//