ID S2J605_MUCC1 Unreviewed; 449 AA.
AC S2J605;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Fructose-2,6-bisphosphatase {ECO:0000313|EMBL:EPB85551.1};
GN ORFNames=HMPREF1544_07640 {ECO:0000313|EMBL:EPB85551.1};
OS Mucor circinelloides f. circinelloides (strain 1006PhL) (Mucormycosis
OS agent) (Calyptromyces circinelloides).
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC Mucoromycetes; Mucorales; Mucorineae; Mucoraceae; Mucor.
OX NCBI_TaxID=1220926 {ECO:0000313|EMBL:EPB85551.1, ECO:0000313|Proteomes:UP000014254};
RN [1] {ECO:0000313|Proteomes:UP000014254}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1006PhL {ECO:0000313|Proteomes:UP000014254};
RG The Broad Institute Genomics Platform;
RA Cuomo C., Earl A., Findley K., Lee S.C., Walker B., Young S., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome sequence of Mucor circinelloides f. circinelloides 1006PhL.";
RL Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KE124009; EPB85551.1; -; Genomic_DNA.
DR AlphaFoldDB; S2J605; -.
DR STRING; 1220926.S2J605; -.
DR VEuPathDB; FungiDB:HMPREF1544_07640; -.
DR eggNOG; KOG0234; Eukaryota.
DR InParanoid; S2J605; -.
DR OMA; RCMYAYF; -.
DR OrthoDB; 2013830at2759; -.
DR Proteomes; UP000014254; Unassembled WGS sequence.
DR GO; GO:0003873; F:6-phosphofructo-2-kinase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0006003; P:fructose 2,6-bisphosphate metabolic process; IEA:InterPro.
DR GO; GO:0006000; P:fructose metabolic process; IEA:InterPro.
DR CDD; cd07067; HP_PGM_like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.40.50.1240; Phosphoglycerate mutase-like; 1.
DR InterPro; IPR003094; 6Pfruct_kin.
DR InterPro; IPR013079; 6Phosfructo_kin.
DR InterPro; IPR013078; His_Pase_superF_clade-1.
DR InterPro; IPR029033; His_PPase_superfam.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10606:SF44; 6-PHOSPHOFRUCTO 2-KINASE_FRUCTOSE 2,6-BISPHOSPHATASE LONG FORM; 1.
DR PANTHER; PTHR10606; 6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE; 1.
DR Pfam; PF01591; 6PF2K; 1.
DR Pfam; PF00300; His_Phos_1; 1.
DR PIRSF; PIRSF000709; 6PFK_2-Ptase; 1.
DR PRINTS; PR00991; 6PFRUCTKNASE.
DR SMART; SM00855; PGAM; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF53254; Phosphoglycerate mutase-like; 1.
PE 4: Predicted;
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000014254}.
FT DOMAIN 1..203
FT /note="6-phosphofructo-2-kinase"
FT /evidence="ECO:0000259|Pfam:PF01591"
FT BINDING 210..217
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR613078-2"
FT BINDING 261
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR613078-2"
SQ SEQUENCE 449 AA; 51533 MW; A293141218E1151F CRC64;
MVGLPARGKT YIACKVSRYL TWLGIKTQIF SVGNYRRKIA GLNLPHTFFD VHNEEAVKKR
HEAAAMALND MIQWFNKEDG TVGILDATNS TKKARAWINK ELTSRNIQVL FIESICDDEN
VILHNIKDVK LSSPDYCNRD SEAATEDFMK RISHYEACYE TITEQDLTYI KLINVGSQYI
INMIRGYLES RIVYYLMNLH TRPKRIWFSR HGESLFNLED KIGGDAGLSP RGEQYALKLP
ELVKQNIGDR PLTVWTSSMT RTIQTARHLP FPKKQWKALD ELDTGVCDGM TYDEIALKYP
DDFARRDEDK FNYRYRGGES YRDLVLRLEP VIMDLERHEN ILIISHQATI RCMYAYFMGL
SHEELPYARI PLHTIIELKP KAFSCEEKLY KVDVGAVDTF RPKGQMARRL TNDQFVSSTI
PPLQEGASGE IADPKSSILP ITPVSVAPC
//
