ID S2JAX4_MUCC1 Unreviewed; 544 AA.
AC S2JAX4;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=4-coumarate-CoA ligase {ECO:0008006|Google:ProtNLM};
GN ORFNames=HMPREF1544_05932 {ECO:0000313|EMBL:EPB87311.1};
OS Mucor circinelloides f. circinelloides (strain 1006PhL) (Mucormycosis
OS agent) (Calyptromyces circinelloides).
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC Mucoromycetes; Mucorales; Mucorineae; Mucoraceae; Mucor.
OX NCBI_TaxID=1220926 {ECO:0000313|EMBL:EPB87311.1, ECO:0000313|Proteomes:UP000014254};
RN [1] {ECO:0000313|Proteomes:UP000014254}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1006PhL {ECO:0000313|Proteomes:UP000014254};
RG The Broad Institute Genomics Platform;
RA Cuomo C., Earl A., Findley K., Lee S.C., Walker B., Young S., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome sequence of Mucor circinelloides f. circinelloides 1006PhL.";
RL Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KE123971; EPB87311.1; -; Genomic_DNA.
DR AlphaFoldDB; S2JAX4; -.
DR STRING; 1220926.S2JAX4; -.
DR VEuPathDB; FungiDB:HMPREF1544_05932; -.
DR eggNOG; KOG1176; Eukaryota.
DR InParanoid; S2JAX4; -.
DR OMA; AVWSGDT; -.
DR OrthoDB; 1404660at2759; -.
DR Proteomes; UP000014254; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0003824; F:catalytic activity; IEA:UniProt.
DR CDD; cd05911; Firefly_Luc_like; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR PANTHER; PTHR24096:SF149; 4-COUMARATE--COA LIGASE 1-RELATED; 1.
DR PANTHER; PTHR24096; LONG-CHAIN-FATTY-ACID--COA LIGASE; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000014254};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 228..251
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 27..392
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 443..522
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 544 AA; 59827 MW; C57AF0AB854E3292 CRC64;
MVYSSKLPSL NLPKSSIIQF LFANKFNTPE DRPLLIDANN GRNLTLAELK DQVLRFGAGL
QDVCEFQTND VVAVYAPNQY NYFVPILGAL AANGAATTAN PNYNVDELSY QLEMSRAKVI
ICHEENLKTA LKAADRVGIS KSNIFVFGES SINGIQPFQK ALLVSRRSAP DTLTYEEAKD
KVAYLCFSSG TTGKSKGVMT THANVTANTC QWTSIDDSFV DRSKDRMIAV LPFFHIFGLS
AILHTAVYWG IPVHVLPRFD LNKFCEIVEK EQITIAPLVP PIYVLLAKEE AVSNFDLSSL
RIGISGAAPL SASLGREVKA RLPHLSIKQG YGLTEISPAA ISEPLDRVID GSIGILLPNM
FAKVVDEDGK ETAQGERGEL WLKGPNVMKG YLHNPQATAE CIDDEGYFHT GDVVIVDENQ
HFFVVDRIKE LIKYKGFQVP PAELEGILLK SPIVADAAVV GVYDSAQATE MPRAYVTLVS
GAAPSEKLAR QIMKFVADQV VPYKQLRSLR FVDTIPKSPS GKILRRVLRD AAHQEENADN
RPKL
//
