ID S2JE27_MUCC1 Unreviewed; 560 AA.
AC S2JE27;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=[histone H3]-trimethyl-L-lysine(9) demethylase {ECO:0000256|ARBA:ARBA00012900};
DE EC=1.14.11.66 {ECO:0000256|ARBA:ARBA00012900};
GN ORFNames=HMPREF1544_04639 {ECO:0000313|EMBL:EPB88526.1};
OS Mucor circinelloides f. circinelloides (strain 1006PhL) (Mucormycosis
OS agent) (Calyptromyces circinelloides).
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC Mucoromycetes; Mucorales; Mucorineae; Mucoraceae; Mucor.
OX NCBI_TaxID=1220926 {ECO:0000313|EMBL:EPB88526.1, ECO:0000313|Proteomes:UP000014254};
RN [1] {ECO:0000313|Proteomes:UP000014254}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1006PhL {ECO:0000313|Proteomes:UP000014254};
RG The Broad Institute Genomics Platform;
RA Cuomo C., Earl A., Findley K., Lee S.C., Walker B., Young S., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome sequence of Mucor circinelloides f. circinelloides 1006PhL.";
RL Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-
CC [histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + N(6)-methyl-L-
CC lysyl(9)-[histone H3] + 2 succinate; Xref=Rhea:RHEA:60200, Rhea:RHEA-
CC COMP:15538, Rhea:RHEA-COMP:15542, ChEBI:CHEBI:15379,
CC ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:16842,
CC ChEBI:CHEBI:30031, ChEBI:CHEBI:61929, ChEBI:CHEBI:61961;
CC EC=1.14.11.66; Evidence={ECO:0000256|ARBA:ARBA00000040};
CC -!- SIMILARITY: Belongs to the JHDM3 histone demethylase family.
CC {ECO:0000256|ARBA:ARBA00009711}.
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DR EMBL; KE123949; EPB88526.1; -; Genomic_DNA.
DR AlphaFoldDB; S2JE27; -.
DR STRING; 1220926.S2JE27; -.
DR VEuPathDB; FungiDB:HMPREF1544_04639; -.
DR eggNOG; KOG0955; Eukaryota.
DR eggNOG; KOG0958; Eukaryota.
DR InParanoid; S2JE27; -.
DR OMA; IPIQRCV; -.
DR OrthoDB; 48111at2759; -.
DR Proteomes; UP000014254; Unassembled WGS sequence.
DR GO; GO:0140684; F:histone H3K9me2/H3K9me3 demethylase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd15571; ePHD; 1.
DR Gene3D; 2.30.30.140; -; 1.
DR Gene3D; 2.60.120.650; Cupin; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR034732; EPHD.
DR InterPro; IPR003347; JmjC_dom.
DR InterPro; IPR003349; JmjN.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR10694; LYSINE-SPECIFIC DEMETHYLASE; 1.
DR PANTHER; PTHR10694:SF7; LYSINE-SPECIFIC DEMETHYLASE 4B-RELATED; 1.
DR Pfam; PF02373; JmjC; 1.
DR Pfam; PF02375; JmjN; 1.
DR Pfam; PF13771; zf-HC5HC2H; 1.
DR SMART; SM00558; JmjC; 1.
DR SMART; SM00545; JmjN; 1.
DR SUPFAM; SSF51197; Clavaminate synthase-like; 1.
DR PROSITE; PS51805; EPHD; 1.
DR PROSITE; PS51184; JMJC; 1.
DR PROSITE; PS51183; JMJN; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000014254};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 17..58
FT /note="JmjN"
FT /evidence="ECO:0000259|PROSITE:PS51183"
FT DOMAIN 158..324
FT /note="JmjC"
FT /evidence="ECO:0000259|PROSITE:PS51184"
FT DOMAIN 371..490
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS51805"
SQ SEQUENCE 560 AA; 64771 MW; 9298429991D98346 CRC64;
MTVAPTAYYD QENGGKIPIF TPTWDEFKDF KAFVESIEEY GKESGIVKII PPKEWKNQLP
KIQQHQINNI KVTKPITQHI IGGRGVFTQT NIEDRKEYTL QQWYEICQKD QHRPLLRNNH
QHSQETSNLT VDQYKEIERN YWRNITFNQP MYGADLLGTL FNSSITSWNP NTLDNTLNKL
NQTLPGVNSP YLYFGMWKAT FAWHVEDMDL YSINYIHFGA PKQWYVVQPC HQKRFETFMQ
STFFNQYKSC HEFLRHKTFI VSPTVLENNN IPIQRCVQQA GEFIITYPFG YHSGYNLDFN
CAESVNFAMD SWLEIGRKAK PCTCIDDSVV IDVNSLFDGV LNSTVDHSTT TTTTTTTAKN
KRKFDEITRQ ENACVLCSNP TLQQHQEPLL ATSDNSHHKH IHKVCAESVD ETYIVKNIVH
GIDAIPASRW KLVCVYCKKK EGACMQCCYG RCWKAFHATC AIKHDATLKR IHSDASNSHS
LYDGYCPQHD PKRIDEKKKL KEAQMREMAK KFQVGLEVLM KWRGGGMYTG TVSECLPDQK
MCRVLLTDGS VRKVSWRDIV
//
