ID   S2JIF0_MUCC1            Unreviewed;       502 AA.
AC   S2JIF0;
DT   18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT   18-SEP-2013, sequence version 1.
DT   27-MAR-2024, entry version 32.
DE   RecName: Full=sphingosine kinase {ECO:0000256|ARBA:ARBA00044037};
DE            EC=2.7.1.91 {ECO:0000256|ARBA:ARBA00044037};
GN   ORFNames=HMPREF1544_03478 {ECO:0000313|EMBL:EPB89679.1};
OS   Mucor circinelloides f. circinelloides (strain 1006PhL) (Mucormycosis
OS   agent) (Calyptromyces circinelloides).
OC   Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC   Mucoromycetes; Mucorales; Mucorineae; Mucoraceae; Mucor.
OX   NCBI_TaxID=1220926 {ECO:0000313|EMBL:EPB89679.1, ECO:0000313|Proteomes:UP000014254};
RN   [1] {ECO:0000313|Proteomes:UP000014254}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1006PhL {ECO:0000313|Proteomes:UP000014254};
RG   The Broad Institute Genomics Platform;
RA   Cuomo C., Earl A., Findley K., Lee S.C., Walker B., Young S., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome sequence of Mucor circinelloides f. circinelloides 1006PhL.";
RL   Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a sphingoid base + ATP = a sphingoid 1-phosphate + ADP + H(+);
CC         Xref=Rhea:RHEA:51496, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:76941, ChEBI:CHEBI:84410, ChEBI:CHEBI:456216;
CC         EC=2.7.1.91; Evidence={ECO:0000256|ARBA:ARBA00043822};
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DR   EMBL; KE123931; EPB89679.1; -; Genomic_DNA.
DR   AlphaFoldDB; S2JIF0; -.
DR   STRING; 1220926.S2JIF0; -.
DR   VEuPathDB; FungiDB:HMPREF1544_03478; -.
DR   eggNOG; KOG1116; Eukaryota.
DR   InParanoid; S2JIF0; -.
DR   OMA; QAWSRRI; -.
DR   OrthoDB; 374620at2759; -.
DR   Proteomes; UP000014254; Unassembled WGS sequence.
DR   GO; GO:0016301; F:kinase activity; IEA:InterPro.
DR   Gene3D; 2.60.200.40; -; 1.
DR   InterPro; IPR017438; ATP-NAD_kinase_N.
DR   InterPro; IPR001206; Diacylglycerol_kinase_cat_dom.
DR   InterPro; IPR016064; NAD/diacylglycerol_kinase_sf.
DR   PANTHER; PTHR12358:SF31; LD11247P-RELATED; 1.
DR   PANTHER; PTHR12358; SPHINGOSINE KINASE; 1.
DR   Pfam; PF00781; DAGK_cat; 1.
DR   SMART; SM00046; DAGKc; 1.
DR   SUPFAM; SSF111331; NAD kinase/diacylglycerol kinase-like; 1.
DR   PROSITE; PS50146; DAGK; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000014254}.
FT   DOMAIN          135..277
FT                   /note="DAGKc"
FT                   /evidence="ECO:0000259|PROSITE:PS50146"
SQ   SEQUENCE   502 AA;  55443 MW;  6B42D438D1BB4D45 CRC64;
     MSTNTLFVEK LGKQVQIIFD TKSLRIQSDA TVIVPQQKKS KKSRSCVCLP TLEANDDLSS
     SASSSLPIPH RNILHANYNA RTNMVQLNVL VADKPSDPES TTQLFKFMYT VKDNEQEKAT
     AFCHNIMTSV YQDLIPEKRL LILINPFGGQ SKAKSIFEEK VKPVLEAAKC KLDVQYTEHR
     YHALEIAKGL DIESCDTIVT VSGDGLIHEV INGFLQRPDA REALQKVSLG LIPAGTSNSL
     SISMSGEKLG FDATHNALQI IKGRPLALDL CSITYEDNRY FSFLSQSFGI AAYADLGTEH
     MRWMGDNRTV VGLMQEIFSK STYQMEASLL IAESDKEKIK QNYKSGLKAS EWKSPAVGDG
     TVQDTIPPLS EPVPENWTTI NGDISIFLAS NVPLLNRGML SHPCVSANDG FIDLMLVRGG
     KGIGKQLSMF TSVDTGKHLD MDMVEYYKVK AFRLKPIVKP GKNAYVAIDG EHASTKQFQV
     EVHQALGSVL SLNPTFINTN VQ
//