ID S2JJI8_MUCC1 Unreviewed; 2414 AA.
AC S2JJI8;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=TOG domain-containing protein {ECO:0000259|SMART:SM01349};
GN ORFNames=HMPREF1544_03075 {ECO:0000313|EMBL:EPB90099.1};
OS Mucor circinelloides f. circinelloides (strain 1006PhL) (Mucormycosis
OS agent) (Calyptromyces circinelloides).
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC Mucoromycetes; Mucorales; Mucorineae; Mucoraceae; Mucor.
OX NCBI_TaxID=1220926 {ECO:0000313|EMBL:EPB90099.1, ECO:0000313|Proteomes:UP000014254};
RN [1] {ECO:0000313|Proteomes:UP000014254}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1006PhL {ECO:0000313|Proteomes:UP000014254};
RG The Broad Institute Genomics Platform;
RA Cuomo C., Earl A., Findley K., Lee S.C., Walker B., Young S., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome sequence of Mucor circinelloides f. circinelloides 1006PhL.";
RL Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the GCN1 family.
CC {ECO:0000256|ARBA:ARBA00007366}.
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DR EMBL; KE123925; EPB90099.1; -; Genomic_DNA.
DR STRING; 1220926.S2JJI8; -.
DR VEuPathDB; FungiDB:HMPREF1544_03075; -.
DR eggNOG; KOG1242; Eukaryota.
DR InParanoid; S2JJI8; -.
DR OMA; KYATQRG; -.
DR OrthoDB; 6844at2759; -.
DR Proteomes; UP000014254; Unassembled WGS sequence.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 7.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR022716; Gcn1_N.
DR InterPro; IPR000357; HEAT.
DR InterPro; IPR021133; HEAT_type_2.
DR InterPro; IPR034085; TOG.
DR PANTHER; PTHR23346:SF7; EIF-2-ALPHA KINASE ACTIVATOR GCN1; 1.
DR PANTHER; PTHR23346; TRANSLATIONAL ACTIVATOR GCN1-RELATED; 1.
DR Pfam; PF12074; Gcn1_N; 1.
DR Pfam; PF02985; HEAT; 1.
DR SMART; SM01349; TOG; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR PROSITE; PS50077; HEAT_REPEAT; 3.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000014254};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1376..1603
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT REPEAT 1547..1585
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REPEAT 1666..1704
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REPEAT 2024..2061
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
SQ SEQUENCE 2414 AA; 266213 MW; 88791ACEA2263223 CRC64;
MAESHENTGE LGWPEFIKTR VVTTITYSGV SDRLDFLNHS LLIRLRRKDL PVESLAPLLQ
LIFLTISRYN DRASRMAIIE VIKELNNWNA PVFQKMFVPV IAREADKFGK RKPTGECVSP
ASDRLVLLNW VNVLLTCVLK EVTVEAAKTN AMFAAILNAQ AVLIDSLVDD SRKSIGKSAV
ADVRRTIRLN ADAIPTMMDV ALANASTCTP SCRNAVLIGT IIDVSLRLKT RSDGKAMVEH
AEARLTEYYL KNIVSSRTAV HTAALDSFND FITHIVTKQK FEAEYLPVLD KMMLRSPEIV
LLALARITPA FSFDPSSIFA AKWLDPLLNH LRSTSPTTVK GAKALWEALA QVCREADALI
KVTEGVSKLL TSGKVNSWEH RVIMYNALSS LAQATEPVVS QKSLEGYFTM IAKEAHEQAM
AAAVDGVGRH LTVLIYNDEF CSANKEFVDK VVKTSTDGLN AAKPLARKSW ANAVGTTVWD
HKDATSATLS ANIVKYLQAL FKTFNKIVDK PLMWKDGPVE AYVMISIISG RIQHWPTVPE
PVADLLKTQK YPSQVLISQP KPSYLLWDRI YTKALTAEEG LWLVRALTSV FMEETQDSLE
KTGAGHLAAQ ALVWIIASHP DHTVRRSAYQ EVSSMAASEP IKLDHFMKQA IKQWLLDIEN
NVKDSTAVSA VNADNYNKET ATFRLAAVLN AITSYDKDLA ESTKGVELID MMILAHHEYI
ASPTNRYNWI TLVQRANVDP GKLVREKSSK IFDMLKSTLE ARSESELFYK AALDTISTLA
FISPDTIPEF IELASENLAP ELMKDIGELE SSIWKCPADI TFVDVLKKDK KTESRSNRKG
NNDDQWEEEL RAELAKKKGL AQKLTKEEQF AVNTQLKKEA AIRANVQSIF EKVTLGLDMT
RALVSGNAEG VEEYLVDLIR MLLDAAKHNV GLLVGDVLVD TYLQLGDCVV EDIQPIRDAI
ALAALRSNKI HPIPSRWLDE PLGALVSRVL YRLRFITESR PLPPASFGYV FPVLYQVIEQ
GAIECEKNDE AAQEQIVMAI DVIGFHCTLG DSFMMPRQEM IDILLRSIKE YPASSKAAKT
SLVTLCEAMA DSVSSDEINT LLQGLLSSEV LVRTAALQGL ELLDLTDIDY SPQLWVACHD
ENESNAELAN QQWEDNAMEV DENFRDQLLT YIVSDSNYVR QAASKALAEA VEEYPEAVYD
TLQAIYARYK KLAAPLDPEY DEYGMVIPET LDRADPWEAR VGLALTLKAV APFMQLENAS
GFCKFLINDH ALGDRNEQVR KQMLEAGLAV INAYGKVDVE EFLETFENYL NSETDNSDVQ
DHIRQAVVIL YGGAAGYLSP GDEKVSTAVE KLIETLDTPS ETVQSAVADC LPPLIKMCKD
EVPRLIKALL NKLFKGEKYA HRRGAAYGLA GVVKGRGITA LKECNVMNSL KDAIDNKRAY
EYRQGALFAF ETLSATLGRL FEPYIIQIIP LLLVCSSDAN MDVREASSDA ARVIMSKISG
HCVKLILPSI LEGLDERQWR TKKASVELLG SMAYCAPKQL SVSLPNIIPR ISEVLADTHS
QVQAAANRSL QLFGEVISNP EIQELVPVLL KALCDPNGKT APALTALLQT SFVHYIDPPS
LALVMPILER GLRERATEIK TKSAQIVGNM ASLTDQKDLV PYLNIILPGL HEVLVDPVPA
ARGTAAKALG ALVEKLGEEN FPGLVLDLLD TLKTDSGGVD RQGAAQGLSE VLAGLGLERL
DGLLPEIISN ADSPRAYVRE GFISLLIYLP ATFGPRFQPY LGRIIPPILM GLADESEYVR
DASLRAGRMI VTNYAVKAVD LLLPELEKGL FDPKWRIRQS SVQLVGELLF RITGITNKNN
DMALGNVEEL GDDDADAVHE DYGSDTKKKQ LVEVLGKERR DRILAALYIV RQDASGVVRQ
ASLQVWKVLV ANTPRTLKDI LAVMMSMIIK TLSSEDFEQR AVAGRTLSEI VQKLGEGVLP
EILPILEEGM ASDDDDTRLG VTVAFSEIMT SAGKLQVLDF ADQITPVIRK ALCDPSDEVR
EAAAQAFDTL HQNVGARAID DILPSLLNKL QSSDESSAYA LSALKEIMSV RSNVVFPVLI
PTLITVPISA FNARALASLV TVAGPALNKR LTAILEALVE TLMTEQDPET IETLKATTEA
FLLSVDDEDG LHTLTVTLME YARDDDPAKR AIACDITAQF FNESELDATY YVADWIHLLM
LLLDDPSEKV IESAWNALTA VTKSLPKEEY EELVIPTRRA LTTIGVAGVD IPGFCLPKGI
SCILPIFLQG LMYGSTDVRE QAALAVGDLI DRTSAVALKP FVTQITGPLI RILGDRYPAE
VKAAILQTLS LMLNKVPMHL KLFLPQLQRT FVKSYSDSTS DVVRERAAAA LKVLSTLQPR
VDPTVAEILK NENL
//
