ID S2JJT5_MUCC1 Unreviewed; 874 AA.
AC S2JJT5;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=DH domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=HMPREF1544_10476 {ECO:0000313|EMBL:EPB82773.1};
OS Mucor circinelloides f. circinelloides (strain 1006PhL) (Mucormycosis
OS agent) (Calyptromyces circinelloides).
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC Mucoromycetes; Mucorales; Mucorineae; Mucoraceae; Mucor.
OX NCBI_TaxID=1220926 {ECO:0000313|EMBL:EPB82773.1, ECO:0000313|Proteomes:UP000014254};
RN [1] {ECO:0000313|Proteomes:UP000014254}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1006PhL {ECO:0000313|Proteomes:UP000014254};
RG The Broad Institute Genomics Platform;
RA Cuomo C., Earl A., Findley K., Lee S.C., Walker B., Young S., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome sequence of Mucor circinelloides f. circinelloides 1006PhL.";
RL Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KE124099; EPB82773.1; -; Genomic_DNA.
DR AlphaFoldDB; S2JJT5; -.
DR STRING; 1220926.S2JJT5; -.
DR VEuPathDB; FungiDB:HMPREF1544_10476; -.
DR eggNOG; KOG3519; Eukaryota.
DR InParanoid; S2JJT5; -.
DR OMA; QPIYPRQ; -.
DR OrthoDB; 23973at2759; -.
DR Proteomes; UP000014254; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd05992; PB1; 1.
DR CDD; cd13246; PH_Scd1; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR010481; Cdc24/Scd1_N.
DR InterPro; IPR033511; Cdc24/Scd1_PH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR000270; PB1_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR47339; CELL DIVISION CONTROL PROTEIN 24; 1.
DR PANTHER; PTHR47339:SF1; CELL DIVISION CONTROL PROTEIN 24; 1.
DR Pfam; PF06395; CDC24; 1.
DR Pfam; PF00564; PB1; 1.
DR Pfam; PF15411; PH_10; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00666; PB1; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF54277; CAD & PB1 domains; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS51745; PB1; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000014254}.
FT DOMAIN 189..363
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 387..507
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 788..874
FT /note="PB1"
FT /evidence="ECO:0000259|PROSITE:PS51745"
FT REGION 508..540
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 561..641
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 654..775
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 508..530
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 589..606
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 622..640
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 677..775
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 874 AA; 98888 MW; 37D64005A8E1204F CRC64;
MIDMPMPSFS ITNKPSSGTS LYHTCRSVLD KLALVEGMTY YLDFENLSLI TSTTGSSVMS
SESGSTTSSG NLSNDPLTKL WELCRRGAPL ATLFNALNPA EPLKLDFTQN QQLNECKKTV
YHFIVACRNQ LEFKEEDVFT LSDLYKDNTN GFVKVVNTID LILQLLEEKG IICTKDSANR
NSLNAPKDTR DKVVHEMLET ERKYVQDLEI LQNYMRELQI QEVLNPDTIH YLFGNLNTLV
DFQRRFLIYL EEIGEKPAEE QNFGALFSQM EDQFTVYEPY CANYFSAQDL VVQEAPKLQK
LAGILNPVYE LPSMLIKPVQ RICKYPLLLN QLIKSMKPDW PHYEDMEEGL ESVRRVTEKV
NETQRKHENI QVVDDLKRRV DEMRTAQIDS FGSLLLHDKL VMQQPDESDK EMYIFFFERT
MLICKESKDA TKNKTAKSIK KKRRGSLQPK GLIVMSKILS VRNTSTGEGN WCLRVDWKDG
EVHTVTLRFR NEEQVKLWES TLKRRMSPMK STVSNTQLAS MKNAHQQVPA SLRTDDDDEY
NDDATLAQRA RSNSLSAHLL NSISGRPKIP RNMSADQAGH GKQRYAAGTN SPLPRTSSSA
NTHNAHDYYY PASPPPSNPS SPTTSSRASQ SSTTSSVRVG ASPLADIASK FMSTGSSTED
DYRQFPLPPP PPPHVNRSQS HSAASPYHTI SATTYHQQQQ LQQQQQLSAS PRLRSQSSPN
IHHNNTSNIE DAPQLPFNSR TLYQTPPSPL DSPIRDSNIS YRTTNSNTSR ISDLSNQQVP
LSPISSISGC VKIKLNYNDG IYVVMCSSEV LYYELMDKVE RKIRLVANLQ PNDVLRLKYQ
DEDGDLITIN SDDDVQMAFE SRGNLNTINL FVSV
//
