ID   S2JPY5_MUCC1            Unreviewed;       142 AA.
AC   S2JPY5;
DT   18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT   18-SEP-2013, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   RecName: Full=Phosphatidylglycerol/phosphatidylinositol transfer protein {ECO:0000256|ARBA:ARBA00016056};
GN   ORFNames=HMPREF1544_11441 {ECO:0000313|EMBL:EPB81820.1};
OS   Mucor circinelloides f. circinelloides (strain 1006PhL) (Mucormycosis
OS   agent) (Calyptromyces circinelloides).
OC   Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC   Mucoromycetes; Mucorales; Mucorineae; Mucoraceae; Mucor.
OX   NCBI_TaxID=1220926 {ECO:0000313|EMBL:EPB81820.1, ECO:0000313|Proteomes:UP000014254};
RN   [1] {ECO:0000313|Proteomes:UP000014254}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1006PhL {ECO:0000313|Proteomes:UP000014254};
RG   The Broad Institute Genomics Platform;
RA   Cuomo C., Earl A., Findley K., Lee S.C., Walker B., Young S., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome sequence of Mucor circinelloides f. circinelloides 1006PhL.";
RL   Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the intermembrane transfer of phosphatidylglycerol
CC       and phosphatidylinositol. {ECO:0000256|ARBA:ARBA00002053}.
CC   -!- SUBUNIT: Monomer. {ECO:0000256|ARBA:ARBA00011245}.
CC   -!- SIMILARITY: Belongs to the NPC2 family.
CC       {ECO:0000256|ARBA:ARBA00006370}.
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DR   EMBL; KE124146; EPB81820.1; -; Genomic_DNA.
DR   AlphaFoldDB; S2JPY5; -.
DR   VEuPathDB; FungiDB:HMPREF1544_11441; -.
DR   eggNOG; KOG4680; Eukaryota.
DR   InParanoid; S2JPY5; -.
DR   OrthoDB; 5472305at2759; -.
DR   Proteomes; UP000014254; Unassembled WGS sequence.
DR   GO; GO:0032934; F:sterol binding; IEA:InterPro.
DR   GO; GO:0015918; P:sterol transport; IEA:InterPro.
DR   Gene3D; 2.70.220.10; Ganglioside GM2 activator; 1.
DR   InterPro; IPR036846; GM2-AP_sf.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR003172; ML_dom.
DR   InterPro; IPR039670; NPC2-like.
DR   PANTHER; PTHR11306; NIEMANN PICK TYPE C2 PROTEIN NPC2-RELATED; 1.
DR   PANTHER; PTHR11306:SF0; PHOSPHATIDYLGLYCEROL_PHOSPHATIDYLINOSITOL TRANSFER PROTEIN; 1.
DR   Pfam; PF02221; E1_DerP2_DerF2; 1.
DR   SMART; SM00737; ML; 1.
DR   SUPFAM; SSF81296; E set domains; 1.
PE   3: Inferred from homology;
KW   Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW   Reference proteome {ECO:0000313|Proteomes:UP000014254};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Transport {ECO:0000256|ARBA:ARBA00023055}.
FT   DOMAIN          25..136
FT                   /note="MD-2-related lipid-recognition"
FT                   /evidence="ECO:0000259|SMART:SM00737"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   142 AA;  15946 MW;  55FC6910EEC7024B CRC64;
     MASSNITKSA ESPQVLQRST SKTSVHLCGS RQGTFKIDYI KLDPNPPAKG QNLNIEFSGY
     LEEEVPRYSY IDLSVKLGFF EVLHKQIDLC SEVLRNGPFC PVSIGSYHYS TSISVSSMIP
     NFCSSQWRLF CSLRMGKYRM GS
//