ID S2JQI7_MUCC1 Unreviewed; 836 AA.
AC S2JQI7;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=Peptide hydrolase {ECO:0000256|RuleBase:RU361240};
DE EC=3.4.-.- {ECO:0000256|RuleBase:RU361240};
GN ORFNames=HMPREF1544_08365 {ECO:0000313|EMBL:EPB84863.1};
OS Mucor circinelloides f. circinelloides (strain 1006PhL) (Mucormycosis
OS agent) (Calyptromyces circinelloides).
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC Mucoromycetes; Mucorales; Mucorineae; Mucoraceae; Mucor.
OX NCBI_TaxID=1220926 {ECO:0000313|EMBL:EPB84863.1, ECO:0000313|Proteomes:UP000014254};
RN [1] {ECO:0000313|Proteomes:UP000014254}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1006PhL {ECO:0000313|Proteomes:UP000014254};
RG The Broad Institute Genomics Platform;
RA Cuomo C., Earl A., Findley K., Lee S.C., Walker B., Young S., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome sequence of Mucor circinelloides f. circinelloides 1006PhL.";
RL Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May be involved in vacuolar sorting and osmoregulation.
CC {ECO:0000256|ARBA:ARBA00003273}.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000256|ARBA:ARBA00004128};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004128}.
CC -!- SIMILARITY: Belongs to the peptidase M28 family.
CC {ECO:0000256|ARBA:ARBA00010918, ECO:0000256|RuleBase:RU361240}.
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DR EMBL; KE124027; EPB84863.1; -; Genomic_DNA.
DR AlphaFoldDB; S2JQI7; -.
DR STRING; 1220926.S2JQI7; -.
DR VEuPathDB; FungiDB:HMPREF1544_08365; -.
DR eggNOG; KOG2194; Eukaryota.
DR InParanoid; S2JQI7; -.
DR OMA; SPLGNDM; -.
DR OrthoDB; 277019at2759; -.
DR Proteomes; UP000014254; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008235; F:metalloexopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR045175; M28_fam.
DR InterPro; IPR007484; Peptidase_M28.
DR PANTHER; PTHR12147; METALLOPEPTIDASE M28 FAMILY MEMBER; 1.
DR PANTHER; PTHR12147:SF56; VACUOLAR MEMBRANE PROTEASE; 1.
DR Pfam; PF04389; Peptidase_M28; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|RuleBase:RU361240};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|RuleBase:RU361240};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|RuleBase:RU361240};
KW Reference proteome {ECO:0000313|Proteomes:UP000014254};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Vacuole {ECO:0000256|ARBA:ARBA00022554};
KW Zinc {ECO:0000256|RuleBase:RU361240}.
FT TRANSMEM 26..46
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 363..389
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 409..435
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 447..470
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 482..502
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 509..529
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 535..553
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 574..592
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 604..625
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 143..332
FT /note="Peptidase M28"
FT /evidence="ECO:0000259|Pfam:PF04389"
SQ SEQUENCE 836 AA; 92901 MW; 0D6FB599F203DDD1 CRC64;
MSADSDERTP LIRQNPSTSH SSKRLYHVYG MALGFLFLFA AFIHSFRTKL PAPLSDAQAR
ELDDFSGIHA YNEYLSRFTA PHSANTRENG VMRDWLASVS YDMQKDATAR GLQMDVIGND
TSEAVVPQDW FTDNEHWFIH SRNVIVRLNG TSGRDEALLI NAHYVDSVPT SNGVTDNGMG
VVTALEMMRY FIEHPPRNTI IFLFNNFEEG GLLGCKTFIH HPWYASVKLF INLEGAGAGG
RAMMFRSSNL NAVQKLAGSD AKLVHSSPLG NDMFKAQIIK SDTDYSVFTQ NGVPGLDIAF
YAPRSHYHTP RDNLAHTTPD ALQYMGQMAL AAAKAIVNSD DMLDTNRDNE LFVYFDILGR
WMFVYSFTTF QIINLIALLL VPSIGLFLGL KNKPSQQTAF SLVKQKLCLV AQGGIAVFSA
LVFACLFVVV AVLAMCKINP SMTYGDVYGA GLYTFAAAFL GIQFSQLVLP NKLKQTLATT
DAAWYGLLSF WSLFLVLAMY AGSKSIASLY FVVYLLAFNA LAALLQAVVP ATQKFRSPLI
FFTQTIMPFI LLLEMEFLSM DALRHATADG TPEIAVYIFI ALPLVLIALH FVPWVHVACN
YRKATIAAAV AFFFLFTICS ALQPFNGSWS PNKLVFKQEY NAGDALATVI VTSATGVQAT
IKSSIPAHEY KTVECSSFNK HLTRCTYQTD LLPKYGGNDT LSEFVLSEVE KTCSETSCIS
SATYASKNSL MCRVFFDPTQ NDYEAIQHVW VNGREHKASN ISSIITYINN YEQPVNVKVE
YPKERSPKAT FSCFYDEWTE LEVPAFNAFR DSLPESATVL IRGQGIALVN YKNVTL
//
