ID   S2JR49_MUCC1            Unreviewed;       757 AA.
AC   S2JR49;
DT   18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT   18-SEP-2013, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   RecName: Full=alpha-L-fucosidase {ECO:0000256|ARBA:ARBA00012662};
DE            EC=3.2.1.51 {ECO:0000256|ARBA:ARBA00012662};
GN   ORFNames=HMPREF1544_02241 {ECO:0000313|EMBL:EPB90987.1};
OS   Mucor circinelloides f. circinelloides (strain 1006PhL) (Mucormycosis
OS   agent) (Calyptromyces circinelloides).
OC   Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC   Mucoromycetes; Mucorales; Mucorineae; Mucoraceae; Mucor.
OX   NCBI_TaxID=1220926 {ECO:0000313|EMBL:EPB90987.1, ECO:0000313|Proteomes:UP000014254};
RN   [1] {ECO:0000313|Proteomes:UP000014254}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1006PhL {ECO:0000313|Proteomes:UP000014254};
RG   The Broad Institute Genomics Platform;
RA   Cuomo C., Earl A., Findley K., Lee S.C., Walker B., Young S., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome sequence of Mucor circinelloides f. circinelloides 1006PhL.";
RL   Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Alpha-L-fucosidase is responsible for hydrolyzing the alpha-
CC       1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the
CC       carbohydrate moieties of glycoproteins.
CC       {ECO:0000256|ARBA:ARBA00004071}.
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 29 family.
CC       {ECO:0000256|ARBA:ARBA00007951}.
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DR   EMBL; KE123914; EPB90987.1; -; Genomic_DNA.
DR   AlphaFoldDB; S2JR49; -.
DR   STRING; 1220926.S2JR49; -.
DR   VEuPathDB; FungiDB:HMPREF1544_02241; -.
DR   eggNOG; KOG3340; Eukaryota.
DR   InParanoid; S2JR49; -.
DR   OMA; NEWINDQ; -.
DR   OrthoDB; 2955544at2759; -.
DR   Proteomes; UP000014254; Unassembled WGS sequence.
DR   GO; GO:0004560; F:alpha-L-fucosidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006004; P:fucose metabolic process; IEA:InterPro.
DR   Gene3D; 3.20.20.80; Glycosidases; 1.
DR   InterPro; IPR016286; FUC_metazoa-typ.
DR   InterPro; IPR000933; Glyco_hydro_29.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   PANTHER; PTHR10030; ALPHA-L-FUCOSIDASE; 1.
DR   PANTHER; PTHR10030:SF46; ALPHA-L-FUCOSIDASE-RELATED; 1.
DR   Pfam; PF01120; Alpha_L_fucos; 1.
DR   PRINTS; PR00741; GLHYDRLASE29.
DR   SMART; SM00812; Alpha_L_fucos; 1.
DR   SUPFAM; SSF51445; (Trans)glycosidases; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Reference proteome {ECO:0000313|Proteomes:UP000014254};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           18..757
FT                   /note="alpha-L-fucosidase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004497668"
SQ   SEQUENCE   757 AA;  86031 MW;  08361C0D4A487137 CRC64;
     MLLLLYILLA CIGLYHASPL YKSDPFPVNI GPWLNNKAFG ANADFDGVGT YFEHDSFQHP
     ELLVKYKSLM SHNNDNIQQS TANDVVIPLQ QQAAIRNVTL GALYMLVSSS HGPSTLDITV
     TYHDATVDRT TLSLPDWQDQ YTHQMERYQA VRYSLSNNNL GALFSVPVYV NPNKMPISIS
     IPPTDKESAI HIFAMTAYPT RPSLLFSSTR PTNEWINDQH QVVQVNLHNV DSNWVQNARV
     HVSSSQVRTI ESGYIKAIAP GHTRSVRVIV QAHTSSTLHN LVSVQYAHSG DNKNTMTIHA
     PLSLQATTSF ESTSSSVQQH RPPNWLKQSK FGIFIHWGLY SVPSWAPVGQ SYAEWYWWRM
     NHKDDAAFDY HRQHYGDNFE YDDFLAQWKP TEFDPHRWLS LVDQSRAKYF VFTTKHHDGI
     ALFDTHVTDR STMHLLQPNR DFVKELMDTA ERDYPQLKRG LYFSLPEWYH PKYKDDSLGW
     QGPPVNPYTG QRVPYTGSRT IHDFVNELQV PQFQELVQYK PDVLWCDIGG IHNSSVWQSN
     YFNQALASGK QVAVNDRCGD SSASDFTTIE YKAVTDTPTR FWEATRGIDP YSFGYNRETT
     PEAYASAFDL IKDLVDAVSR GGNFLLNIGP KASGQMPQPM VDRLTSIGAW LDAVGQSIFD
     SVPYWIASAQ DKLRFTASQD GGCVYVFSFS QQTQSRQTIE ITTPLPILQD TSKITLLNDN
     TTAIQWRYTS AGNMLLDFCL SDNHHKPEIL VFKISFL
//