ID S2KDE9_MUCC1 Unreviewed; 906 AA.
AC S2KDE9;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=Peptidase S8/S53 domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=HMPREF1544_02886 {ECO:0000313|EMBL:EPB90360.1};
OS Mucor circinelloides f. circinelloides (strain 1006PhL) (Mucormycosis
OS agent) (Calyptromyces circinelloides).
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC Mucoromycetes; Mucorales; Mucorineae; Mucoraceae; Mucor.
OX NCBI_TaxID=1220926 {ECO:0000313|EMBL:EPB90360.1, ECO:0000313|Proteomes:UP000014254};
RN [1] {ECO:0000313|Proteomes:UP000014254}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1006PhL {ECO:0000313|Proteomes:UP000014254};
RG The Broad Institute Genomics Platform;
RA Cuomo C., Earl A., Findley K., Lee S.C., Walker B., Young S., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome sequence of Mucor circinelloides f. circinelloides 1006PhL.";
RL Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase S8 family.
CC {ECO:0000256|ARBA:ARBA00011073, ECO:0000256|PROSITE-ProRule:PRU01240}.
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DR EMBL; KE123922; EPB90360.1; -; Genomic_DNA.
DR AlphaFoldDB; S2KDE9; -.
DR STRING; 1220926.S2KDE9; -.
DR VEuPathDB; FungiDB:HMPREF1544_02886; -.
DR eggNOG; KOG4266; Eukaryota.
DR InParanoid; S2KDE9; -.
DR OMA; MSANRMI; -.
DR OrthoDB; 662485at2759; -.
DR Proteomes; UP000014254; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd07489; Peptidases_S8_5; 1.
DR Gene3D; 3.50.30.30; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR InterPro; IPR010435; Fn3_5.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR046450; PA_dom_sf.
DR InterPro; IPR003137; PA_domain.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR022398; Peptidase_S8_His-AS.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR InterPro; IPR034187; Peptidases_S8_5.
DR PANTHER; PTHR43806:SF59; CEREVISIN-RELATED; 1.
DR PANTHER; PTHR43806; PEPTIDASE S8; 1.
DR Pfam; PF06280; fn3_5; 1.
DR Pfam; PF02225; PA; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR PRINTS; PR00723; SUBTILISIN.
DR SUPFAM; SSF52025; PA domain; 1.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00137; SUBTILASE_HIS; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000014254};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}.
FT DOMAIN 165..567
FT /note="Peptidase S8/S53"
FT /evidence="ECO:0000259|Pfam:PF00082"
FT DOMAIN 401..475
FT /note="PA"
FT /evidence="ECO:0000259|Pfam:PF02225"
FT DOMAIN 624..743
FT /note="Fn3-like"
FT /evidence="ECO:0000259|Pfam:PF06280"
FT ACT_SITE 174
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 233
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 548
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 906 AA; 97091 MW; 5098F78BEBE0E679 CRC64;
MRVNNSNFFS AITTLLVIAL ITIPCLTTAR RLDSIYHPKY IHSSVKCLKG RYLIELAATS
DVDSMLSRLT ENKLGVKVHR SFRHKFFSGL SIEVLDYDSI GSLLDETSVV SMSANRMIQR
ASPIPPVKRA EPNANSTFTP ETIKSLMPHN ASQVNKVRQE LNLTGQGVFV GIIDSGIDYT
LKALGGGFGP GFKVIAGYDL VGDKYNSSDP RSTTKADNDP LDSCGKNSAA DGHGTHVAGI
IAGFDPDNNF EGVAPGASLG MWRVFSCDGE STTDEVLLDA LIMAYEAGVH IISMSIGSIL
PFSDDSVPLV KVVNQITAAG VSVVVAAGNE GSNGVYSVSA PSTALSALSV ASVVNQVYNP
PYKLNITGMD ESIDAFTSAD SNKPFINGSL AIASSNSTDL AEDACDTRLV SKSVQGKIAL
VKRGTCSFTA KVKNAASAGA LGVIIYNNVD AELESVNAED SIPVVSISLR NGLKLLSLIS
NATAPIEVTA IKVDGFIPNL KANTISEFSS IGPTAELNFK PNIAAVGQTV FSTLPRYLGS
YGIRDGTSMA CPYIAGSLAL YLQHHGTNRT DTAAMHTKFK NYAFPLHVGH AASNVIESPI
RQGAGLVQVY DAITQPVLIS PSEISFNDTS SSNYITHSLT ITNNAIYAVS YSISSKISIG
IAPYNQTGSM YNSLNQPSVN QEAPSTIQFS TSELHLNPGE SQVVTVTVAP PSADPQNHIM
YGGFIQFNPL NQTSTHKAIH VPYIGVTGSQ RDLAIFKEGI QPKYNNQSAI TLTGNQVTYK
FNASISYFKT DYFVLFEFGL INPTKLIKAE VVRELGKQVL GQISLPATNV PATSKDNDMY
IGWNGYYFND TVASLEPDQV NSTYAMPSTT GSYFIQISAL KLFGDPQKEI DWESWRSGII
DIDRIN
//
