ID   S2KIU8_MUCC1            Unreviewed;      1287 AA.
AC   S2KIU8;
DT   18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT   18-SEP-2013, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   SubName: Full=5-oxoprolinase (ATP-hydrolysing) {ECO:0000313|EMBL:EPB92360.1};
GN   ORFNames=HMPREF1544_00658 {ECO:0000313|EMBL:EPB92360.1};
OS   Mucor circinelloides f. circinelloides (strain 1006PhL) (Mucormycosis
OS   agent) (Calyptromyces circinelloides).
OC   Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC   Mucoromycetes; Mucorales; Mucorineae; Mucoraceae; Mucor.
OX   NCBI_TaxID=1220926 {ECO:0000313|EMBL:EPB92360.1, ECO:0000313|Proteomes:UP000014254};
RN   [1] {ECO:0000313|Proteomes:UP000014254}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1006PhL {ECO:0000313|Proteomes:UP000014254};
RG   The Broad Institute Genomics Platform;
RA   Cuomo C., Earl A., Findley K., Lee S.C., Walker B., Young S., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome sequence of Mucor circinelloides f. circinelloides 1006PhL.";
RL   Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the oxoprolinase family.
CC       {ECO:0000256|ARBA:ARBA00010403}.
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DR   EMBL; KE123900; EPB92360.1; -; Genomic_DNA.
DR   STRING; 1220926.S2KIU8; -.
DR   VEuPathDB; FungiDB:HMPREF1544_00658; -.
DR   eggNOG; KOG1939; Eukaryota.
DR   InParanoid; S2KIU8; -.
DR   OMA; TDCNVML; -.
DR   OrthoDB; 674at2759; -.
DR   Proteomes; UP000014254; Unassembled WGS sequence.
DR   GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR   InterPro; IPR049517; ACX-like_C.
DR   InterPro; IPR008040; Hydant_A_N.
DR   InterPro; IPR002821; Hydantoinase_A.
DR   InterPro; IPR003692; Hydantoinase_B.
DR   InterPro; IPR045079; Oxoprolinase_fam.
DR   PANTHER; PTHR11365:SF2; 5-OXOPROLINASE; 1.
DR   PANTHER; PTHR11365; 5-OXOPROLINASE RELATED; 1.
DR   Pfam; PF19278; Hydant_A_C; 1.
DR   Pfam; PF05378; Hydant_A_N; 1.
DR   Pfam; PF01968; Hydantoinase_A; 1.
DR   Pfam; PF02538; Hydantoinase_B; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000014254}.
FT   DOMAIN          12..228
FT                   /note="Hydantoinase/oxoprolinase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05378"
FT   DOMAIN          248..543
FT                   /note="Hydantoinase A/oxoprolinase"
FT                   /evidence="ECO:0000259|Pfam:PF01968"
FT   DOMAIN          556..727
FT                   /note="Acetophenone carboxylase-like C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF19278"
FT   DOMAIN          752..1286
FT                   /note="Hydantoinase B/oxoprolinase"
FT                   /evidence="ECO:0000259|Pfam:PF02538"
SQ   SEQUENCE   1287 AA;  139218 MW;  19D616444683144C CRC64;
     MSLPTTTAPL TICIDRGGTF TDCIGFVGKP GDENYQEYVV KLLSEDPSNY KDAPTEGIRR
     IVELATGKKH PRSEPVPTTN IESVRMGTTV ATNALLERKG ESSALLITKG FGDLLTIGNQ
     SRPKIFDLSI SKPDVLYQKV IEIDERVVLL NSAASSEQVD PQEIKDDKVS QGISGEWVKV
     VRAPDLDAIQ RQLQALYEEG YKSIAICLLH SYTFPDHEQQ IGELAKSIGF DHVSLSSQVM
     PMVKIVPRGT SATADAYLTP CIKKYIKGFV SGFDDGFEKG TTQLQFMQSD GGLVPVSNFS
     GFKAILSGPA GGVVGYALTT FDKHAKVPVI GFDMGGTSTD VSRFDGHYEH VFETTTAGVT
     IQAPQLDINT VAAGGGSMLF FKNGMFVVGP ESAGAHPGPA CYRKGGPLAV SDANLYLGRL
     LPDYFPKIFG PNEDQPLDRD IVEKKFQQLA DTINSSTGEH KTLDEIVYGF IKVANETMCR
     PIRALTEAKG HDTSNHTLAV FGGAGGQHAC GIARNLGINK IVLYRHSSIL SAFGLALADV
     VHEVQEPSAE KLNTGLSRIQ ERVLHLQKES VAELSKQGFR ECDIVTEVYL NLRYDGTDCA
     LMTLQPAADN WDFENAFYQV YTQEFGFLLK DRDIIVDDIR VRGIGKTIQK NDLTPDRDIE
     ELKAANKIVQ ISNATDSFAS VYFEETGRDD RVPVYRLGDL KPGSCIAGPA IIIDVTATVV
     VEPSCTALIT AGHITITVGR GEKKVVTTEL EPIQLSIFSH RFMSIAEQMG RTLQKTAIST
     NIKERLDFSC ALFGADGGLV ANAPHIPVHL GSLSHAVIYQ LNYYNGQLSE GDVIMTNHPQ
     AGGSHLPDIT IITPVFDKGK IVFFVASRGH HADIGGISPG SMPPHSKELY QEGAAIKSFK
     IVSKGHFDQK GLEEHLCTIP ASYPGCSGSR AFRDNISDLK AQIAANQKGI NLVKSLIQEY
     SLEVVQAYMM HIRRNASEAV KSLLKQVAKD HSEQLIATDH MDDGTPIHLK VSIDPVQGTA
     LFDFQGTGPE VYGNTNTPES VCHSAIIYSI RCLVNQDIPL NSGCLEPISI NIPANSILSP
     SERCAVVGGN VLTSQRLVDV VLKAFNACAA SQGCCNNLTF GKGGKNEDTG KTTTGWGYYE
     TIAGGSGAGP TWEGQSGVHT HMTNTRITDP EILEKRYPVI LHQFAIRPHT GGQGKHKGGD
     GVIREIEFLE DGIQVSILSE RRVFSPYGLA GGGDGEKGLN IWVRHETSSQ GEPVVRTLNM
     TGKNSALFGR GDRIVINTPG GGGYGQK
//