ID   S2KK19_HALAF            Unreviewed;       432 AA.
AC   S2KK19;
DT   18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT   18-SEP-2013, sequence version 1.
DT   27-MAR-2024, entry version 45.
DE   RecName: Full=L-fuconate dehydratase {ECO:0000256|ARBA:ARBA00013142};
DE            EC=4.2.1.68 {ECO:0000256|ARBA:ARBA00013142};
GN   ORFNames=L861_14790 {ECO:0000313|EMBL:EPC02300.1};
OS   Halomonas anticariensis (strain DSM 16096 / CECT 5854 / LMG 22089 / FP35).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Oceanospirillales;
OC   Halomonadaceae; Halomonas.
OX   NCBI_TaxID=1121939 {ECO:0000313|EMBL:EPC02300.1, ECO:0000313|Proteomes:UP000014463};
RN   [1] {ECO:0000313|EMBL:EPC02300.1, ECO:0000313|Proteomes:UP000014463}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 16096 / CECT 5854 / LMG 22089 / FP35
RC   {ECO:0000313|Proteomes:UP000014463};
RX   PubMed=23868129; DOI=10.1128/genomeA.00497-13;
RA   Tahrioui A., Quesada E., Llamas I.;
RT   "Draft genome sequence of the moderately halophilic gammaproteobacterium
RT   Halomonas anticariensis FP35.";
RL   Genome Announc. 1:31-31(2013).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-fuconate = 2-dehydro-3-deoxy-L-fuconate + H2O;
CC         Xref=Rhea:RHEA:22772, ChEBI:CHEBI:15377, ChEBI:CHEBI:21291,
CC         ChEBI:CHEBI:37448; EC=4.2.1.68;
CC         Evidence={ECO:0000256|ARBA:ARBA00001737};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EPC02300.1}.
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DR   EMBL; ASTJ01000025; EPC02300.1; -; Genomic_DNA.
DR   RefSeq; WP_016416703.1; NZ_KE332388.1.
DR   AlphaFoldDB; S2KK19; -.
DR   STRING; 1121939.L861_14790; -.
DR   PATRIC; fig|1121939.11.peg.2197; -.
DR   eggNOG; COG4948; Bacteria.
DR   OrthoDB; 9782675at2; -.
DR   Proteomes; UP000014463; Unassembled WGS sequence.
DR   GO; GO:0050023; F:L-fuconate dehydratase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009063; P:amino acid catabolic process; IEA:InterPro.
DR   GO; GO:0016052; P:carbohydrate catabolic process; IEA:InterPro.
DR   CDD; cd03324; rTSbeta_L-fuconate_dehydratase; 1.
DR   Gene3D; 3.20.20.120; Enolase-like C-terminal domain; 1.
DR   Gene3D; 3.30.390.10; Enolase-like, N-terminal domain; 1.
DR   InterPro; IPR036849; Enolase-like_C_sf.
DR   InterPro; IPR029017; Enolase-like_N.
DR   InterPro; IPR029065; Enolase_C-like.
DR   InterPro; IPR034610; L-fuconate_dehydratase.
DR   InterPro; IPR018110; Mandel_Rmase/mucon_lact_enz_CS.
DR   InterPro; IPR013342; Mandelate_racemase_C.
DR   InterPro; IPR013341; Mandelate_racemase_N_dom.
DR   InterPro; IPR046945; RHMD-like.
DR   PANTHER; PTHR13794; ENOLASE SUPERFAMILY, MANDELATE RACEMASE; 1.
DR   PANTHER; PTHR13794:SF58; MITOCHONDRIAL ENOLASE SUPERFAMILY MEMBER 1; 1.
DR   Pfam; PF13378; MR_MLE_C; 1.
DR   Pfam; PF02746; MR_MLE_N; 1.
DR   SFLD; SFLDS00001; Enolase; 1.
DR   SFLD; SFLDF00111; L-fuconate_dehydratase; 1.
DR   SMART; SM00922; MR_MLE; 1.
DR   SUPFAM; SSF51604; Enolase C-terminal domain-like; 1.
DR   SUPFAM; SSF54826; Enolase N-terminal domain-like; 1.
DR   PROSITE; PS00909; MR_MLE_2; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000014463}.
FT   DOMAIN          197..293
FT                   /note="Mandelate racemase/muconate lactonizing enzyme C-
FT                   terminal"
FT                   /evidence="ECO:0000259|SMART:SM00922"
SQ   SEQUENCE   432 AA;  48517 MW;  7026BBCE77FC4F0D CRC64;
     MTTITRLDVQ DIRFPTSQSL DGSDAMNTAP DYSATYVTLH TDDRHEGHGL TFTIGRGNEI
     CVAAVKSLAY LVKGRRLASI TSDMGAFWRE ITGDSQLRWL GPDKGVIHLA TAAIVNAVWD
     LWAKTAGKPV WKLLVDMSPE ELVRCLDFRF VSDALTPEEA LALLRRREEG KAEREREMYQ
     RGYPAYTTSA GWLGYSDDKV RHLAREALAE GWTHFKQKVG GDLEEDCRRA RILREEIGWE
     RPLMMDANQM WDVDEAITKM RRLAEFDPLW IEEPTSPDDI LGHAEIRRRL APIGVATGEH
     CHNKVMFKQL LQAGALDYCQ VDAARLGGLN EVILVVLLAA KYGVPVCPHA GGVGLCEYVQ
     HVSLFDYIAV SASLEGRVLE YVDHLHEHFV DPVVIQGGRY QVPRAPGYSI TMHAESLAHH
     RYPDGEAWQQ EA
//