ID S2KQP4_HALAF Unreviewed; 732 AA.
AC S2KQP4;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=Tyrosine protein kinase {ECO:0008006|Google:ProtNLM};
GN ORFNames=L861_02535 {ECO:0000313|EMBL:EPC04210.1};
OS Halomonas anticariensis (strain DSM 16096 / CECT 5854 / LMG 22089 / FP35).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Oceanospirillales;
OC Halomonadaceae; Halomonas.
OX NCBI_TaxID=1121939 {ECO:0000313|EMBL:EPC04210.1, ECO:0000313|Proteomes:UP000014463};
RN [1] {ECO:0000313|EMBL:EPC04210.1, ECO:0000313|Proteomes:UP000014463}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 16096 / CECT 5854 / LMG 22089 / FP35
RC {ECO:0000313|Proteomes:UP000014463};
RX PubMed=23868129; DOI=10.1128/genomeA.00497-13;
RA Tahrioui A., Quesada E., Llamas I.;
RT "Draft genome sequence of the moderately halophilic gammaproteobacterium
RT Halomonas anticariensis FP35.";
RL Genome Announc. 1:31-31(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216;
CC Evidence={ECO:0000256|ARBA:ARBA00001074};
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004429}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the etk/wzc family.
CC {ECO:0000256|ARBA:ARBA00008883}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EPC04210.1}.
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DR EMBL; ASTJ01000011; EPC04210.1; -; Genomic_DNA.
DR RefSeq; WP_016414944.1; NZ_KE332377.1.
DR AlphaFoldDB; S2KQP4; -.
DR STRING; 1121939.L861_02535; -.
DR PATRIC; fig|1121939.11.peg.472; -.
DR eggNOG; COG0489; Bacteria.
DR eggNOG; COG3206; Bacteria.
DR OrthoDB; 9775724at2; -.
DR Proteomes; UP000014463; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0045226; P:extracellular polysaccharide biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05387; BY-kinase; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR025669; AAA_dom.
DR InterPro; IPR032807; GNVR.
DR InterPro; IPR003856; LPS_length_determ_N_term.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005702; Wzc-like_C.
DR NCBIfam; TIGR01007; eps_fam; 1.
DR PANTHER; PTHR32309; TYROSINE-PROTEIN KINASE; 1.
DR PANTHER; PTHR32309:SF13; TYROSINE-PROTEIN KINASE ETK-RELATED; 1.
DR Pfam; PF13614; AAA_31; 1.
DR Pfam; PF13807; GNVR; 1.
DR Pfam; PF02706; Wzz; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000014463};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137}.
FT TRANSMEM 31..50
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 443..465
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 15..105
FT /note="Polysaccharide chain length determinant N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02706"
FT DOMAIN 384..463
FT /note="Tyrosine kinase G-rich"
FT /evidence="ECO:0000259|Pfam:PF13807"
FT DOMAIN 547..668
FT /note="AAA"
FT /evidence="ECO:0000259|Pfam:PF13614"
FT COILED 271..312
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 732 AA; 80656 MW; 47EE9DEDC2E9F0AF CRC64;
MTQMPSIPSA SKESDEIELG RIFGVLLDHK WWIIFITIFS ALLGIVYSTL STPIYQGDAL
VQIERRSTLS PLGDLSNVLG VEDFNTSAEI QILQSRMVLG QAVDRLGQDT LIMPVSLPYI
GDYIMRRGIP RPSFMEGQPH IWGGESIEVA RFQLAAGRRG QVIVVERANN ESYRVLINDQ
PVGIGDIGRV VVFLDGELEL RIDEFNAPPG AQFRLFKMPR SSAISSLGSR LLILEAGGRG
TSTGVLRLSM TGTDRQEIEN SLNAVVETFL TQNIERQSAQ AEQSLAFLEE QAPELRSQLK
LAEERLNEYR VKLDSIDVSS EAQTAIQRYI AIEGRLNELE FEEAELAQLF QPSHPSYQAL
MRQKQHLADE KAELNARVNE LPAAQQEVLR LTRDVEVTQA IYVNVLNKIQ ELQVAKAGSI
GNVRIIDRAQ VGYWPIAPNK TRIVILATLI GCMLAVGGVL LRALLRRGVE TPEQIEATGV
PVYATIPLSD GQSKLVTRVK HRRDRTGKQV ISGILASLNP TDPAVEALRS LRTSLHFVML
EAKNNLIMVT GSSPGAGKSF VTINLGVTCA QAGQKVLIID ADMRKGQVHN AFAETSKGGL
SELLAGKVEW QEVIRPTRVP GLFYISRGEA PPNPSELLVH ENFNWFLDGF SPEYDLVIID
TPPALAVTDA AIVGKRVGTT LLVARFRMNT PREISAALRR LETAGVTVKG CILNAMENKA
AVGYGYHHYV YK
//
