ID S2XFZ2_9BACL Unreviewed; 206 AA.
AC S2XFZ2;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE RecName: Full=Kynurenine formamidase {ECO:0000256|ARBA:ARBA00014889};
DE EC=3.5.1.9 {ECO:0000256|ARBA:ARBA00012930};
GN ORFNames=HMPREF1210_02686 {ECO:0000313|EMBL:EPD50716.1};
OS Paenisporosarcina sp. HGH0030.
OC Bacteria; Bacillota; Bacilli; Bacillales; Planococcaceae;
OC Paenisporosarcina.
OX NCBI_TaxID=1078085 {ECO:0000313|EMBL:EPD50716.1, ECO:0000313|Proteomes:UP000014412};
RN [1] {ECO:0000313|EMBL:EPD50716.1, ECO:0000313|Proteomes:UP000014412}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HGH0030 {ECO:0000313|EMBL:EPD50716.1,
RC ECO:0000313|Proteomes:UP000014412};
RG The Broad Institute Genomics Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Schmidt T.M., Dai D., Dover J.,
RA Kim K., Walker B., Young S., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA Abouelleil A., Allen A.W., Alvarado L., Arachchi H.M., Berlin A.M.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sisk P.,
RA Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Paenisporosarcina sp. HGH0030.";
RL Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-
CC kynurenine, the second step in the kynurenine pathway of tryptophan
CC degradation. {ECO:0000256|ARBA:ARBA00002204}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + N-formyl-L-kynurenine = formate + H(+) + L-kynurenine;
CC Xref=Rhea:RHEA:13009, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:15740, ChEBI:CHEBI:57959, ChEBI:CHEBI:58629; EC=3.5.1.9;
CC Evidence={ECO:0000256|ARBA:ARBA00000640};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EPD50716.1}.
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DR EMBL; AGEQ01000015; EPD50716.1; -; Genomic_DNA.
DR RefSeq; WP_016429189.1; NZ_KE150422.1.
DR AlphaFoldDB; S2XFZ2; -.
DR STRING; 1078085.HMPREF1210_02686; -.
DR PATRIC; fig|1078085.3.peg.2674; -.
DR eggNOG; COG1878; Bacteria.
DR HOGENOM; CLU_030671_3_1_9; -.
DR Proteomes; UP000014412; Unassembled WGS sequence.
DR GO; GO:0004061; F:arylformamidase activity; IEA:UniProtKB-EC.
DR GO; GO:0004328; F:formamidase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0019441; P:tryptophan catabolic process to kynurenine; IEA:InterPro.
DR Gene3D; 3.50.30.50; Putative cyclase; 1.
DR InterPro; IPR007325; KFase/CYL.
DR InterPro; IPR037175; KFase_sf.
DR InterPro; IPR017484; Kynurenine_formamidase_bac.
DR NCBIfam; TIGR03035; trp_arylform; 1.
DR PANTHER; PTHR31118; CYCLASE-LIKE PROTEIN 2; 1.
DR PANTHER; PTHR31118:SF32; KYNURENINE FORMAMIDASE; 1.
DR Pfam; PF04199; Cyclase; 1.
DR SUPFAM; SSF102198; Putative cyclase; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000014412};
KW Tryptophan catabolism {ECO:0000256|ARBA:ARBA00023079};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
SQ SEQUENCE 206 AA; 22793 MW; 67911A8F75EEF287 CRC64;
MKIHDISMLL NQNVAEWPGD TPFQFHINWT KEQSGSVNVG QITTSTHIGT HIDAPFHFDE
NGKKVHELPL ENYIVDAIVI DVSGSEVISR ELLKGKVTGE AKAVLFRTNA WQQRDVFPEA
IPAFDADIVD WMVENELSLF GVDLPSVDAI TSKDLPMHHA LGTAGRYILE GLILDDLKEA
TYQLIALPLK IEGADGSPVR AVLIEK
//
