ID S2XPR5_9BACL Unreviewed; 460 AA.
AC S2XPR5;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE RecName: Full=isochorismate synthase {ECO:0000256|ARBA:ARBA00012824};
DE EC=5.4.4.2 {ECO:0000256|ARBA:ARBA00012824};
DE AltName: Full=Isochorismate mutase {ECO:0000256|ARBA:ARBA00041564};
GN ORFNames=HMPREF1210_00021 {ECO:0000313|EMBL:EPD54036.1};
OS Paenisporosarcina sp. HGH0030.
OC Bacteria; Bacillota; Bacilli; Bacillales; Planococcaceae;
OC Paenisporosarcina.
OX NCBI_TaxID=1078085 {ECO:0000313|EMBL:EPD54036.1, ECO:0000313|Proteomes:UP000014412};
RN [1] {ECO:0000313|EMBL:EPD54036.1, ECO:0000313|Proteomes:UP000014412}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HGH0030 {ECO:0000313|EMBL:EPD54036.1,
RC ECO:0000313|Proteomes:UP000014412};
RG The Broad Institute Genomics Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Schmidt T.M., Dai D., Dover J.,
RA Kim K., Walker B., Young S., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA Abouelleil A., Allen A.W., Alvarado L., Arachchi H.M., Berlin A.M.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sisk P.,
RA Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Paenisporosarcina sp. HGH0030.";
RL Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chorismate = isochorismate; Xref=Rhea:RHEA:18985,
CC ChEBI:CHEBI:29748, ChEBI:CHEBI:29780; EC=5.4.4.2;
CC Evidence={ECO:0000256|ARBA:ARBA00000799};
CC -!- SIMILARITY: Belongs to the isochorismate synthase family.
CC {ECO:0000256|ARBA:ARBA00005297}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EPD54036.1}.
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DR EMBL; AGEQ01000003; EPD54036.1; -; Genomic_DNA.
DR RefSeq; WP_016426536.1; NZ_KE150421.1.
DR AlphaFoldDB; S2XPR5; -.
DR STRING; 1078085.HMPREF1210_00021; -.
DR PATRIC; fig|1078085.3.peg.1; -.
DR eggNOG; COG1169; Bacteria.
DR HOGENOM; CLU_006493_8_4_9; -.
DR Proteomes; UP000014412; Unassembled WGS sequence.
DR GO; GO:0008909; F:isochorismate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR Gene3D; 3.60.120.10; Anthranilate synthase; 1.
DR InterPro; IPR005801; ADC_synthase.
DR InterPro; IPR019999; Anth_synth_I-like.
DR InterPro; IPR015890; Chorismate_C.
DR InterPro; IPR004561; IsoChor_synthase.
DR NCBIfam; TIGR00543; isochor_syn; 1.
DR PANTHER; PTHR42839; ISOCHORISMATE SYNTHASE ENTC; 1.
DR PANTHER; PTHR42839:SF1; ISOCHORISMATE SYNTHASE MENF; 1.
DR Pfam; PF00425; Chorismate_bind; 1.
DR PRINTS; PR00095; ANTSNTHASEI.
DR SUPFAM; SSF56322; ADC synthase; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Reference proteome {ECO:0000313|Proteomes:UP000014412}.
FT DOMAIN 194..446
FT /note="Chorismate-utilising enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00425"
SQ SEQUENCE 460 AA; 51906 MW; 1AC82A6F97136057 CRC64;
MKRKSFTSTE YVVEDHSSAV HFYTETIEVN GLSSVAFFEA GESYKGQRFY WQNREKTFTL
VGLGHAHVIT SSSEENRFAE VDKQWNELCS KIVNEEHDLQ PILFGGFSFD PANKLSSEWD
MFPSAYFAVP SFQLVIRDDR VFISIHLITS DKDSQLQFDR LRGERDDLIH AAQVKELKPY
AKPLLTQMDE RFKELYLDAV SHVTKLIHDG EAQKVVIARS LALTFAEEVS SPSAMYHMSK
EQPESFLFGL ELADNLFFGA TPERLVKVEN RRALSTCLAG SVKRGQTATE DQQLGNDLLQ
DSKNREEHQY VVDMITSVFN QYCDDVKVPK YPKLMKIRDI QHLYTPVEGK LQKGQGLLQL
VKDLHPTPAL GGEPRGDAMA IIRMVEQMNR GYYAAPVGWI DAEGNGEFAV AIRSALLNKT
HAYLYAGGGI VADSDPTSEY AETLVKFRPM LRTLGGKLHG
//
