ID   S2XX92_9ACTN            Unreviewed;       497 AA.
AC   S2XX92;
DT   18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT   18-SEP-2013, sequence version 1.
DT   27-MAR-2024, entry version 49.
DE   RecName: Full=GAF domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=HMPREF1211_07123 {ECO:0000313|EMBL:EPD56651.1};
OS   Streptomyces sp. HGB0020.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1078086 {ECO:0000313|EMBL:EPD56651.1, ECO:0000313|Proteomes:UP000014410};
RN   [1] {ECO:0000313|EMBL:EPD56651.1, ECO:0000313|Proteomes:UP000014410}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HGB0020 {ECO:0000313|EMBL:EPD56651.1,
RC   ECO:0000313|Proteomes:UP000014410};
RG   The Broad Institute Genomics Platform;
RA   Earl A., Ward D., Feldgarden M., Gevers D., Schmidt T.M., Dai D., Dover J.,
RA   Kim K., Walker B., Young S., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA   Abouelleil A., Allen A.W., Alvarado L., Arachchi H.M., Berlin A.M.,
RA   Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA   Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA   Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sisk P.,
RA   Sykes S., Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Streptomyces sp. HGB0020.";
RL   Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EPD56651.1}.
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DR   EMBL; AGER01000029; EPD56651.1; -; Genomic_DNA.
DR   RefSeq; WP_016436991.1; NZ_KE150429.1.
DR   AlphaFoldDB; S2XX92; -.
DR   STRING; 1078086.HMPREF1211_07123; -.
DR   PATRIC; fig|1078086.3.peg.7177; -.
DR   HOGENOM; CLU_034370_1_0_11; -.
DR   Proteomes; UP000014410; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   CDD; cd16917; HATPase_UhpB-NarQ-NarX-like; 1.
DR   Gene3D; 1.20.5.1930; -; 1.
DR   Gene3D; 3.30.450.40; -; 3.
DR   Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR   InterPro; IPR003018; GAF.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR011712; Sig_transdc_His_kin_sub3_dim/P.
DR   PANTHER; PTHR24421; NITRATE/NITRITE SENSOR PROTEIN NARX-RELATED; 1.
DR   PANTHER; PTHR24421:SF56; OXYGEN SENSOR HISTIDINE KINASE RESPONSE REGULATOR DOST; 1.
DR   Pfam; PF01590; GAF; 1.
DR   Pfam; PF13185; GAF_2; 1.
DR   Pfam; PF02518; HATPase_c; 1.
DR   Pfam; PF07730; HisKA_3; 1.
DR   SMART; SM00065; GAF; 2.
DR   SMART; SM00387; HATPase_c; 1.
DR   SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR   SUPFAM; SSF55781; GAF domain-like; 2.
PE   4: Predicted;
KW   Kinase {ECO:0000256|ARBA:ARBA00022777};
KW   Reference proteome {ECO:0000313|Proteomes:UP000014410};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT   DOMAIN          9..124
FT                   /note="GAF"
FT                   /evidence="ECO:0000259|SMART:SM00065"
FT   DOMAIN          145..288
FT                   /note="GAF"
FT                   /evidence="ECO:0000259|SMART:SM00065"
FT   DOMAIN          400..497
FT                   /note="Histidine kinase/HSP90-like ATPase"
FT                   /evidence="ECO:0000259|SMART:SM00387"
SQ   SEQUENCE   497 AA;  52708 MW;  990D503D4CAF7273 CRC64;
     MRSVGSGLEL HATLERICET AVALTGARCA AIGVMAEDGD TLVDFVHRGD DEDPCPCGFP
     AHRPPMRSVL GLPIRVQGEI FGTLYLTKKR GGEPFHDDDL DMVRVLAAEA GIAVGNARLY
     EAARQREHWI DGSVAVTTAL LSGGDADEAL QVVADRARRL SGSAAGVVLL PAREGGLEIV
     AVAADGPSGL LGTVVPPQSP LVAELLGGRA VFVEDAAADR RMVTGHARKY GPVMLLPLQS
     DGRVLGALVM PRARGERPFT ETERMLAVQF ASQAALALVM AETQRDRERL AVYEDRDRTA
     RDLHDLVIQR LFATGMLLDS ARRRTRAPEV RDGVARAVDE LDVTIQEIRT AIFALQQGPA
     EKSSGLSTSV LREITMAAVP LGFRPSHRFV GPVDTLVGDL TGKNLVAALR EALSNAFRHA
     GASRIDVVVD ATVTLPDGRP GVRLSVADDG VGIPEGGRRS GLRNLRRRAE SLGGDSGHGP
     GIGADGGGTT VVWQVPY
//