ID S2Y303_9ACTN Unreviewed; 586 AA.
AC S2Y303;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=AB hydrolase-1 domain-containing protein {ECO:0000259|Pfam:PF00561};
GN ORFNames=HMPREF1211_07117 {ECO:0000313|EMBL:EPD56645.1};
OS Streptomyces sp. HGB0020.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1078086 {ECO:0000313|EMBL:EPD56645.1, ECO:0000313|Proteomes:UP000014410};
RN [1] {ECO:0000313|EMBL:EPD56645.1, ECO:0000313|Proteomes:UP000014410}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HGB0020 {ECO:0000313|EMBL:EPD56645.1,
RC ECO:0000313|Proteomes:UP000014410};
RG The Broad Institute Genomics Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Schmidt T.M., Dai D., Dover J.,
RA Kim K., Walker B., Young S., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA Abouelleil A., Allen A.W., Alvarado L., Arachchi H.M., Berlin A.M.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sisk P.,
RA Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Streptomyces sp. HGB0020.";
RL Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC family. {ECO:0000256|ARBA:ARBA00006484}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EPD56645.1}.
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DR EMBL; AGER01000029; EPD56645.1; -; Genomic_DNA.
DR RefSeq; WP_016436985.1; NZ_KE150429.1.
DR AlphaFoldDB; S2Y303; -.
DR STRING; 1078086.HMPREF1211_07117; -.
DR PATRIC; fig|1078086.3.peg.7171; -.
DR HOGENOM; CLU_511581_0_0_11; -.
DR OrthoDB; 4220752at2; -.
DR Proteomes; UP000014410; Unassembled WGS sequence.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR CDD; cd05233; SDR_c; 1.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR000073; AB_hydrolase_1.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR InterPro; IPR002347; SDR_fam.
DR PANTHER; PTHR43391:SF12; OXIDOREDUCTASE EPHD-RELATED; 1.
DR PANTHER; PTHR43391; RETINOL DEHYDROGENASE-RELATED; 1.
DR Pfam; PF00561; Abhydrolase_1; 1.
DR Pfam; PF00106; adh_short; 1.
DR PRINTS; PR00081; GDHRDH.
DR PRINTS; PR00080; SDRFAMILY.
DR SMART; SM00822; PKS_KR; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00061; ADH_SHORT; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000014410}.
FT DOMAIN 30..279
FT /note="AB hydrolase-1"
FT /evidence="ECO:0000259|Pfam:PF00561"
SQ SEQUENCE 586 AA; 63991 MW; DEC2E8FA9FC77427 CRC64;
MTLLKDARER RVHTGGVELC VAELGDAAQP TLVLVHGYPD SKEVWSEVAA RLAERFHVVL
YDVRGHGRST APQPLRGGFT LEKLTDDFLA VIDSVSPGRP VHVVGHDWGS VQAWEFATVR
RTEGRIASFT SMSGPSLDHF GHWIDRRLKK PTPRRIGQLL GQGAKSWYVY LLHTPVLPEL
AWRGPLGKSW PGILRRVEKV PADGYPTPSL PSDAAQGAWL YRDNVRYRLR RPRADAYAHA
PVQLITPLGD AFLSEKLYDD LEQWVPRLTR RTLPAKHWIP RTRPDQLASW ITEFVTSVEG
GRPTAVRPTG RYADRFGGQL VLVTGAGSGI GRATASAFAE AGARVVAVDR DAEAAARTAE
QCRLLGAPEA WAETADVSDE QAMEKLAAKV AAEYGVVDVL VNNAGIGLGG SFFDTTTEDW
KNVLDVNLWG VIHGCRLFGK QMAERGQGGH IVNTASAAAY QPSRALPAYS TSKAAVLMLS
ECLRAELAGQ GIGVSAICPG FVNTNITSTA RFAGVDAEEE RRRQKRTARL YGLRNYPPEK
VAAAILRAVV RNEAVVPVTP EARGTHLMSR FAPRALRAIA RLKPPL
//
