ID   S2YBE2_9ACTN            Unreviewed;       750 AA.
AC   S2YBE2;
DT   18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT   18-SEP-2013, sequence version 1.
DT   27-MAR-2024, entry version 44.
DE   RecName: Full=4Fe-4S Mo/W bis-MGD-type domain-containing protein {ECO:0000259|PROSITE:PS51669};
GN   ORFNames=HMPREF1211_04557 {ECO:0000313|EMBL:EPD61526.1};
OS   Streptomyces sp. HGB0020.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1078086 {ECO:0000313|EMBL:EPD61526.1, ECO:0000313|Proteomes:UP000014410};
RN   [1] {ECO:0000313|EMBL:EPD61526.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HGB0020 {ECO:0000313|EMBL:EPD61526.1};
RG   The Broad Institute Genomics Platform;
RA   Earl A., Ward D., Feldgarden M., Gevers D., Schmidt T.M., Dai D., Dover J.,
RA   Kim K., Walker B., Young S., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA   Abouelleil A., Allen A.W., Alvarado L., Arachchi H.M., Berlin A.M.,
RA   Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA   Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA   Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sisk P.,
RA   Sykes S., Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Streptomyces sp. HGB0020.";
RL   Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|ARBA:ARBA00001966};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EPD61526.1}.
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DR   EMBL; AGER01000016; EPD61526.1; -; Genomic_DNA.
DR   RefSeq; WP_016434492.1; NZ_KE150427.1.
DR   AlphaFoldDB; S2YBE2; -.
DR   STRING; 1078086.HMPREF1211_04557; -.
DR   PATRIC; fig|1078086.3.peg.4607; -.
DR   HOGENOM; CLU_000422_13_3_11; -.
DR   OrthoDB; 7376058at2; -.
DR   Proteomes; UP000014410; Unassembled WGS sequence.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0043546; F:molybdopterin cofactor binding; IEA:InterPro.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   CDD; cd02782; MopB_CT_1; 1.
DR   Gene3D; 2.40.40.20; -; 1.
DR   Gene3D; 3.40.50.740; -; 1.
DR   Gene3D; 2.20.25.90; ADC-like domains; 1.
DR   Gene3D; 3.40.228.10; Dimethylsulfoxide Reductase, domain 2; 1.
DR   InterPro; IPR009010; Asp_de-COase-like_dom_sf.
DR   InterPro; IPR006657; MoPterin_dinucl-bd_dom.
DR   InterPro; IPR006656; Mopterin_OxRdtase.
DR   InterPro; IPR006963; Mopterin_OxRdtase_4Fe-4S_dom.
DR   PANTHER; PTHR43105:SF14; POSSIBLE OXIDOREDUCTASE; 1.
DR   PANTHER; PTHR43105; RESPIRATORY NITRATE REDUCTASE; 1.
DR   Pfam; PF04879; Molybdop_Fe4S4; 1.
DR   Pfam; PF00384; Molybdopterin; 1.
DR   Pfam; PF01568; Molydop_binding; 1.
DR   SMART; SM00926; Molybdop_Fe4S4; 1.
DR   SUPFAM; SSF50692; ADC-like; 1.
DR   SUPFAM; SSF53706; Formate dehydrogenase/DMSO reductase, domains 1-3; 1.
DR   PROSITE; PS51669; 4FE4S_MOW_BIS_MGD; 1.
PE   4: Predicted;
KW   4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW   Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000014410}.
FT   DOMAIN          2..58
FT                   /note="4Fe-4S Mo/W bis-MGD-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51669"
SQ   SEQUENCE   750 AA;  79414 MW;  3437EAD364786FA6 CRC64;
     MSRTALRICP LCEATCGLTL TIEGTRVTGA RGDRDDVFSK GFICPKGASF GALDGDPDRL
     RGPLVRHNGE LREATWEEAF DAVAAGIRPV VERYGPHAVG VVLGNPNVHT MAGALYPPVL
     LAGLGTHSVF TASTVDQMPK HVSSGLLFGD ANAIPVPDLD HTGHLLLIGA NPLESNGSLC
     TAPDFPGRLK ALKARGGTLT VIDPRRTRTA KLADRHIAIR PGTDALLLAA MTHVLFEEDL
     ADPGELTGHL EGIDELREAV RDFTPEAVAA ACDVDADVTR ALARELAAAP TAAVYGRIGS
     CTVPYGTLGS WLVDVLNILT GNLDRPGGAL FPQAATDRTP RPAGPSHGFT LGRWHSRVSQ
     HPEAKGELPL SALAAEIDTA TERGEPIRAL VAVAANPVLS APDGDRLDKA LDSLDFMVSV
     DPYLNETSRH ADVVLPPPPP SQSPHHDFAF NTLAVRNQVR YNRPAVPLEP GRMAETEILA
     RLILAVTGMH GAEPSAVDDM VIGQTLGKAV REPHSPVHGR DPEEIAAQLT GQNGPERRLD
     MMLRLGPYGD GFGVRPDGLT LERLLAHPHG IDLGPLRSRL PQPLKTRSGR IELLPQPIAD
     DLPRLCTALD RLPDGLVLVG RRHLRSNNSW MHNVPALTGG SNRCTLHIHP EDAERLGVQD
     GDAVRVKGAG GAVTAPAEVT DGVRPGVVSL PHGWGHDRPG TRMSHAATDP GVNVNQLLDG
     SLLDPLSGNA VLNGVPVEVT GVAQSIMPLT
//