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Database: UniProt
Entry: S2YFF8_9ACTN
LinkDB: S2YFF8_9ACTN
Original site: S2YFF8_9ACTN 
ID   S2YFF8_9ACTN            Unreviewed;       472 AA.
AC   S2YFF8;
DT   18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT   18-SEP-2013, sequence version 1.
DT   05-JUN-2019, entry version 27.
DE   RecName: Full=Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex {ECO:0000256|RuleBase:RU003423};
DE            EC=2.3.1.- {ECO:0000256|RuleBase:RU003423};
GN   ORFNames=HMPREF1211_07260 {ECO:0000313|EMBL:EPD56142.1};
OS   Streptomyces sp. HGB0020.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1078086 {ECO:0000313|EMBL:EPD56142.1, ECO:0000313|Proteomes:UP000014410};
RN   [1] {ECO:0000313|EMBL:EPD56142.1, ECO:0000313|Proteomes:UP000014410}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HGB0020 {ECO:0000313|EMBL:EPD56142.1,
RC   ECO:0000313|Proteomes:UP000014410};
RG   The Broad Institute Genomics Platform;
RA   Earl A., Ward D., Feldgarden M., Gevers D., Schmidt T.M., Dai D.,
RA   Dover J., Kim K., Walker B., Young S., Zeng Q., Gargeya S.,
RA   Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J.,
RA   Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A.,
RA   Ireland A., Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W.,
RA   Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S.,
RA   Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Streptomyces sp. HGB0020.";
RL   Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=(R)-lipoate; Xref=ChEBI:CHEBI:83088;
CC         Evidence={ECO:0000256|RuleBase:RU003423};
CC   -!- SIMILARITY: Belongs to the 2-oxoacid dehydrogenase family.
CC       {ECO:0000256|RuleBase:RU003423}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EPD56142.1}.
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DR   EMBL; AGER01000030; EPD56142.1; -; Genomic_DNA.
DR   RefSeq; WP_016437121.1; NZ_KE150430.1.
DR   EnsemblBacteria; EPD56142; EPD56142; HMPREF1211_07260.
DR   PATRIC; fig|1078086.3.peg.7313; -.
DR   BioCyc; GCF_000411315-HMP:HMPREF1211_RS35740-MONOMER; -.
DR   BioCyc; GCF_000411315:G1EG4-7243-MONOMER; -.
DR   Proteomes; UP000014410; Unassembled WGS sequence.
DR   GO; GO:0016746; F:transferase activity, transferring acyl groups; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.559.10; -; 1.
DR   Gene3D; 4.10.320.10; -; 1.
DR   InterPro; IPR003016; 2-oxoA_DH_lipoyl-BS.
DR   InterPro; IPR001078; 2-oxoacid_DH_actylTfrase.
DR   InterPro; IPR000089; Biotin_lipoyl.
DR   InterPro; IPR023213; CAT-like_dom_sf.
DR   InterPro; IPR036625; E3-bd_dom_sf.
DR   InterPro; IPR004167; PSBD.
DR   InterPro; IPR011053; Single_hybrid_motif.
DR   Pfam; PF00198; 2-oxoacid_dh; 1.
DR   Pfam; PF00364; Biotin_lipoyl; 1.
DR   Pfam; PF02817; E3_binding; 1.
DR   SUPFAM; SSF47005; SSF47005; 1.
DR   SUPFAM; SSF51230; SSF51230; 1.
DR   PROSITE; PS50968; BIOTINYL_LIPOYL; 1.
DR   PROSITE; PS00189; LIPOYL; 1.
DR   PROSITE; PS51826; PSBD; 1.
PE   3: Inferred from homology;
KW   Acyltransferase {ECO:0000256|RuleBase:RU003423};
KW   Complete proteome {ECO:0000313|Proteomes:UP000014410};
KW   Lipoyl {ECO:0000256|RuleBase:RU003423, ECO:0000256|SAAS:SAAS00065550};
KW   Reference proteome {ECO:0000313|Proteomes:UP000014410};
KW   Transferase {ECO:0000256|RuleBase:RU003423}.
FT   DOMAIN        9     84       Lipoyl-binding. {ECO:0000259|PROSITE:
FT                                PS50968}.
FT   DOMAIN      173    210       Peripheral subunit-binding (PSBD).
FT                                {ECO:0000259|PROSITE:PS51826}.
FT   REGION       88    119       Disordered. {ECO:0000256|MobiDB-lite:
FT                                S2YFF8}.
FT   REGION      126    145       Disordered. {ECO:0000256|MobiDB-lite:
FT                                S2YFF8}.
SQ   SEQUENCE   472 AA;  48966 MW;  D93AB0061E371D80 CRC64;
     MTTMTEASVR EFKMPDVGEG LTEAEILKWY VQPGDTVTDG QVVCEVETAK AAVELPIPYD
     GVVRDLHFPE GATVDVGTPI IAVDVSGGSA APEAPAEPAA AVPAPAEEGK PEGSGRQPVL
     VGYGVAESST KRRPRKGADA EAAQASTAIQ AELNGHAPAP VAEPVATTGQ RPLAKPPVRK
     LAKDLGVDLA TVVPSGPDGI ITREDVHAAL APAAPAPEPS VAAPAAPAPA PAAVASYDSA
     RETRIPIKGV RRATAQAMVG SAFTAPHVTE FVTVDVTRTM KLVEELKQDK EFAGLRVNPL
     LLIAKALLVA LKRNPEINAS WDEAAQEIVV KHYVNLGIAA ATPRGLIVPN IKDAHAKTLP
     QLAESLGELV STAREGKTSP GAMQGGTVTI TNVGVFGVDT GTPILNPGES AILAVGAIKL
     QPWVHKGKVK PRQVTTLALS FDHRLVDGEL GSKVLADVAA ILEQPKRLIT WA
//
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