ID S2YS54_9ACTN Unreviewed; 1010 AA.
AC S2YS54;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=Glycoside hydrolase family 38 central domain-containing protein {ECO:0000259|SMART:SM00872};
GN ORFNames=HMPREF1211_01471 {ECO:0000313|EMBL:EPD67213.1};
OS Streptomyces sp. HGB0020.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1078086 {ECO:0000313|EMBL:EPD67213.1, ECO:0000313|Proteomes:UP000014410};
RN [1] {ECO:0000313|EMBL:EPD67213.1, ECO:0000313|Proteomes:UP000014410}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HGB0020 {ECO:0000313|EMBL:EPD67213.1,
RC ECO:0000313|Proteomes:UP000014410};
RG The Broad Institute Genomics Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Schmidt T.M., Dai D., Dover J.,
RA Kim K., Walker B., Young S., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA Abouelleil A., Allen A.W., Alvarado L., Arachchi H.M., Berlin A.M.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sisk P.,
RA Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Streptomyces sp. HGB0020.";
RL Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 38 family.
CC {ECO:0000256|ARBA:ARBA00009792}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EPD67213.1}.
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DR EMBL; AGER01000004; EPD67213.1; -; Genomic_DNA.
DR RefSeq; WP_016431444.1; NZ_KE150426.1.
DR AlphaFoldDB; S2YS54; -.
DR STRING; 1078086.HMPREF1211_01471; -.
DR PATRIC; fig|1078086.3.peg.1501; -.
DR HOGENOM; CLU_003442_0_1_11; -.
DR OrthoDB; 9772207at2; -.
DR Proteomes; UP000014410; Unassembled WGS sequence.
DR GO; GO:0004559; F:alpha-mannosidase activity; IEA:InterPro.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006013; P:mannose metabolic process; IEA:InterPro.
DR CDD; cd10789; GH38N_AMII_ER_cytosolic; 1.
DR Gene3D; 3.20.110.10; Glycoside hydrolase 38, N terminal domain; 1.
DR Gene3D; 1.20.1270.50; Glycoside hydrolase family 38, central domain; 1.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR041147; GH38_C.
DR InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR InterPro; IPR011682; Glyco_hydro_38_C.
DR InterPro; IPR015341; Glyco_hydro_38_cen.
DR InterPro; IPR037094; Glyco_hydro_38_cen_sf.
DR InterPro; IPR000602; Glyco_hydro_38_N.
DR InterPro; IPR027291; Glyco_hydro_38_N_sf.
DR InterPro; IPR028995; Glyco_hydro_57/38_cen_sf.
DR PANTHER; PTHR46017; ALPHA-MANNOSIDASE 2C1; 1.
DR PANTHER; PTHR46017:SF1; ALPHA-MANNOSIDASE 2C1; 1.
DR Pfam; PF09261; Alpha-mann_mid; 1.
DR Pfam; PF17677; Glyco_hydro38C2; 1.
DR Pfam; PF07748; Glyco_hydro_38C; 1.
DR Pfam; PF01074; Glyco_hydro_38N; 1.
DR SMART; SM00872; Alpha-mann_mid; 1.
DR SUPFAM; SSF88688; Families 57/38 glycoside transferase middle domain; 1.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR SUPFAM; SSF88713; Glycoside hydrolase/deacetylase; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00023295};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000014410}.
FT DOMAIN 520..598
FT /note="Glycoside hydrolase family 38 central"
FT /evidence="ECO:0000259|SMART:SM00872"
SQ SEQUENCE 1010 AA; 110127 MW; D129863401295696 CRC64;
MHDDRNLVEA RLERVLRERV RPAVHPLTAP LSVEIWSTTG EPVPVAEGLA APTRPIAAGT
PWGAPWGTSW FKVTGTVPAE WAGRTVEAVL DLGFTRRTPG FQCEGLVHRP DGTPVKGLHP
RNSYVRVGSP VAGGEQVHWH IEAASNPDLE ASGVPFQPTP MGDKATAGDA PQYVLGEMRL
AVLDETVWNL VIDLEVLGEL MAELPVDGAR RWNILRAVSR ALDALDLQDV NGTAAAARAE
LSDVLAAPAT PAAHRISAVG HAHIDSAWLW PLRETVRKVA RTASNMTALL EEEPDFVFAM
SQAQQYAWLK EHRPEVYARV KKAVADGRFV PAGGMWVESD TNMPGSEAMA RQFVHGKRFF
LDEFGLESDE VWLPDTFGFA AGLPQIIKAA GATRLLTQKI SWSRTNSFPH HTFWWEGVDG
SRVFTHFPPV DTYNCEVTGH QIAHAARNFK EKGVATRSLA PVGYGDGGGG TTREMVARAA
RLRSLEGSAT VEWATPTDFF DRAQAEYPNP PVWVGELYLE LHRATLTSQA QTKRGNRRSE
ALLTEAELWA TTAAIRTGAP YPYEQLDRLW KTVLLHQFHD ILPGSSIAWV HREARETYAR
VAAELEGIVA DAHRALAGDP AGGTELVFNP APHARGGVPA TGASAQPPTG GAVVPVPREE
GGHILDNGLL RVEIDARGLV VSAYDTTAGR EAIAPGQAAN LLQLHPDLPN EWDAWDVDAF
YRNTGSDLTD VTELAVEGTS VRIARSFGAS HVTQVLSMPS GVKRLDIATE VDWHETERFL
KLAFPLDVKA DRYAAETQFG HVYRPTHQNT SWEWAKFEAC NHRFVHVDEP GWGVAVVNDA
TYGHDVTREV RADGGTTTTV RASLLRAPRY PDPETDQGVH HFLHALVPGA TIGDAVREGY
RTNLPERRVT GSVAEVAPLV RVDHEAVVVS AVKLADDHSG DLVVRLYEAH GGRAHATVHV
EAEGAAVEQT VLVDLLERPL AGRGEPTRGE NAVVLDLRPF EMVTLRIPRG
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