ID S2YT67_9CORY Unreviewed; 640 AA.
AC S2YT67;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 24-JAN-2024, entry version 44.
DE SubName: Full=Xanthine permease {ECO:0000313|EMBL:EPD67566.1};
GN ORFNames=HMPREF1219_01978 {ECO:0000313|EMBL:EPD67566.1};
OS Corynebacterium pyruviciproducens ATCC BAA-1742.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales;
OC Corynebacteriaceae; Corynebacterium.
OX NCBI_TaxID=1125779 {ECO:0000313|EMBL:EPD67566.1, ECO:0000313|Proteomes:UP000014408};
RN [1] {ECO:0000313|EMBL:EPD67566.1, ECO:0000313|Proteomes:UP000014408}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-1742 {ECO:0000313|EMBL:EPD67566.1,
RC ECO:0000313|Proteomes:UP000014408};
RG The Broad Institute Genomics Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Tong J., Walker B., Young S.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W.,
RA Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J.,
RA Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A.,
RA Ireland A., Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W.,
RA Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Corynebacterium pyruviciproducens 1773O (ATCC BAA-
RT 1742).";
RL Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC
CC 2.A.40) family. {ECO:0000256|ARBA:ARBA00008821}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EPD67566.1}.
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DR EMBL; ATBY01000017; EPD67566.1; -; Genomic_DNA.
DR RefSeq; WP_016458715.1; NZ_KE150448.1.
DR AlphaFoldDB; S2YT67; -.
DR STRING; 1125779.HMPREF1219_01978; -.
DR PATRIC; fig|1125779.3.peg.1925; -.
DR eggNOG; COG2233; Bacteria.
DR eggNOG; COG3195; Bacteria.
DR HOGENOM; CLU_017959_8_2_11; -.
DR Proteomes; UP000014408; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0015205; F:nucleobase transmembrane transporter activity; IEA:UniProt.
DR GO; GO:0006144; P:purine nucleobase metabolic process; IEA:UniProtKB-KW.
DR Gene3D; 1.10.3330.10; Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase; 1.
DR InterPro; IPR006043; NCS2.
DR InterPro; IPR018020; OHCU_decarboxylase.
DR InterPro; IPR036778; OHCU_decarboxylase_sf.
DR InterPro; IPR017588; UacT-like.
DR InterPro; IPR006042; Xan_ur_permease.
DR NCBIfam; TIGR00801; ncs2; 1.
DR NCBIfam; NF037981; NCS2_1; 1.
DR NCBIfam; TIGR03173; pbuX; 1.
DR PANTHER; PTHR42810; PURINE PERMEASE C1399.01C-RELATED; 1.
DR PANTHER; PTHR42810:SF4; URIC ACID TRANSPORTER UACT; 1.
DR Pfam; PF09349; OHCU_decarbox; 1.
DR Pfam; PF00860; Xan_ur_permease; 1.
DR SUPFAM; SSF158694; UraD-Like; 1.
DR PROSITE; PS01116; XANTH_URACIL_PERMASE; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Purine metabolism {ECO:0000256|ARBA:ARBA00022631};
KW Reference proteome {ECO:0000313|Proteomes:UP000014408};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 22..44
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 56..75
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 87..106
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 118..137
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 143..169
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 181..198
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 204..222
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 251..273
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 328..351
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 357..374
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 386..403
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 423..440
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 462..618
FT /note="Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline
FT decarboxylase"
FT /evidence="ECO:0000259|Pfam:PF09349"
SQ SEQUENCE 640 AA; 67757 MW; F375301A7435E05F CRC64;
MASQSTATLK HPVDVVPPAP KLAALGLQHV LAFYAGAVIV PLLIASSLKL DAATTIHLIN
ADLLTCGIAT IIQSVGIGKH IGVRLPIIQG VTTTAVSPII AIGLGATNGE GGVASLPTIY
GAIIVSGLFT FFAAPIFGKV LKYFPHIVTG TVLLVMGTSL LAVSTNDFVN YAEGIPATRD
LLYGFGTLAV IVLVQRFFHG FLGTLSVLIG LVLGTAVALV LGDTSFADVA TANAFGITTP
FYFGIPRFDL VAIFSMIIVM IITMVETTGD VFATGEIVKK RIRRDDVVRA IRADGVSTLI
GGIMNSFPYT CFAQNVGLVR LTGVKSRWVA TTAAGFMIIL GLLPKAGAVV AAIPSPVLGG
ASLALFANVA WVGLQTIAKA DLSDGRNAAI VTTALGLAML VTFKPEIAEV FPAWAQTFVS
SGMSLGAITA IALNLLFFHV GKQSGAHVSR ATGKGITLAD LNEMDRDEFV ATLRPLFNNE
LFPLQTAWEA RPFADVNELR AAIQVAVLTA PKDKREALIN DYPSMAELLQ VSDDDAATIS
ADRGSLGLTD LDSVQAAKLD DISTAYWEKF GMPFVSYLDT NDTVERVIDA GVRRLANSPE
QEHRAVLSEI VEIANDRFDL LLADANPVRS AWDRKFTEVE
//
