ID S2YZS0_9ACTN Unreviewed; 841 AA.
AC S2YZS0;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=Chaperone ClpB {ECO:0008006|Google:ProtNLM};
GN ORFNames=HMPREF1211_01814 {ECO:0000313|EMBL:EPD67555.1};
OS Streptomyces sp. HGB0020.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1078086 {ECO:0000313|EMBL:EPD67555.1, ECO:0000313|Proteomes:UP000014410};
RN [1] {ECO:0000313|EMBL:EPD67555.1, ECO:0000313|Proteomes:UP000014410}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HGB0020 {ECO:0000313|EMBL:EPD67555.1,
RC ECO:0000313|Proteomes:UP000014410};
RG The Broad Institute Genomics Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Schmidt T.M., Dai D., Dover J.,
RA Kim K., Walker B., Young S., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA Abouelleil A., Allen A.W., Alvarado L., Arachchi H.M., Berlin A.M.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sisk P.,
RA Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Streptomyces sp. HGB0020.";
RL Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: Homohexamer. The oligomerization is ATP-dependent.
CC {ECO:0000256|ARBA:ARBA00026057}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the ClpA/ClpB family.
CC {ECO:0000256|ARBA:ARBA00008675, ECO:0000256|RuleBase:RU004432}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EPD67555.1}.
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DR EMBL; AGER01000004; EPD67555.1; -; Genomic_DNA.
DR RefSeq; WP_016431786.1; NZ_KE150426.1.
DR AlphaFoldDB; S2YZS0; -.
DR STRING; 1078086.HMPREF1211_01814; -.
DR PATRIC; fig|1078086.3.peg.1845; -.
DR HOGENOM; CLU_005070_4_1_11; -.
DR OrthoDB; 9803641at2; -.
DR Proteomes; UP000014410; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd00009; AAA; 1.
DR CDD; cd19499; RecA-like_ClpB_Hsp104-like; 1.
DR Gene3D; 1.10.8.60; -; 2.
DR Gene3D; 1.10.1780.10; Clp, N-terminal domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 4.10.860.10; UVR domain; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR019489; Clp_ATPase_C.
DR InterPro; IPR036628; Clp_N_dom_sf.
DR InterPro; IPR004176; Clp_R_dom.
DR InterPro; IPR001270; ClpA/B.
DR InterPro; IPR018368; ClpA/B_CS1.
DR InterPro; IPR028299; ClpA/B_CS2.
DR InterPro; IPR041546; ClpA/ClpB_AAA_lid.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001943; UVR_dom.
DR PANTHER; PTHR11638; ATP-DEPENDENT CLP PROTEASE; 1.
DR PANTHER; PTHR11638:SF18; HEAT SHOCK PROTEIN 78, MITOCHONDRIAL; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF07724; AAA_2; 1.
DR Pfam; PF17871; AAA_lid_9; 1.
DR Pfam; PF02861; Clp_N; 2.
DR Pfam; PF10431; ClpB_D2-small; 1.
DR PRINTS; PR00300; CLPPROTEASEA.
DR SMART; SM00382; AAA; 2.
DR SMART; SM01086; ClpB_D2-small; 1.
DR SUPFAM; SSF81923; Double Clp-N motif; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51903; CLP_R; 1.
DR PROSITE; PS00870; CLPAB_1; 1.
DR PROSITE; PS00871; CLPAB_2; 1.
DR PROSITE; PS50151; UVR; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU004432};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|RuleBase:RU004432};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU004432};
KW Reference proteome {ECO:0000313|Proteomes:UP000014410};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|PROSITE-
KW ProRule:PRU01251}.
FT DOMAIN 34..183
FT /note="Clp R"
FT /evidence="ECO:0000259|PROSITE:PS51903"
FT DOMAIN 450..485
FT /note="UVR"
FT /evidence="ECO:0000259|PROSITE:PS50151"
FT REGION 78..115
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 163..197
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 446..485
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 173..194
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 841 AA; 92033 MW; D09CBEABAC016A55 CRC64;
MTSGFSGPEG YDPFGEFLAR FFGGPRPGPR QIDIGRLLSQ PARELVRGAA QYAAEHGSRD
LDTQHLLRAA LAAEPTRSLL SRAGADPDSL ATEIDERSGP AQHTAEEAPP PTSLSLTPAV
KRALLDAHDM ARASGAGYIG PEHVLSALAA NPDSAAGHIL NSARFAPTGP QPEAPETGQS
RGEQTRTTGT PTLDKYGRDL TDLARQGRID PVIGRDEEIE QTIEVLSRRG KNNPVLIGDA
GVGKTAIVEG LAQRIADGDV PDVLIGRRVV ALDLTGVVAG TRYRGDFEER LNNIVDEIRS
HSDQLIVFID EVHTVVGAGS GGESGGAMDA GNILKPALAR GELHIVGATT LEEYRRIEKD
AALARRFQPI LVPEPSVPDT IEILRGLRDR YEAHHQVRYT DEALVAAVEL SDRYLTDRRL
PDKAIDLIDQ AGARVRLRAR TKGTDVRALE REIEQLTCDK DQSVADEQYE RAMQLRDRIA
ELKQRIADTG GGVKADEGQL EVTAEAIAEV VSRQTGIPVS SLTQEEKEKL LGLEEHLHER
VVGQEEAVSV VSEAILRSRA GLASPDRPIG SFLFLGPTGV GKTELARALA EALFGSEERM
IRLDMSEYQE RHTVSRLVGA PPGYVGHEEA GQLTEVVRRH PYSLLLLDEV EKAHPDVFNI
LLQVLDDGRL TDSQGRTVDF TNTVIVMTSN LGSEAIGRSG AGIGFGPGDA DADEEARRER
ILRPLREHFR PEFLNRIDET VVFRRLTGDQ LRRITNLLLE KTRRLTHAQG ITVEFTDAAV
DWLAERGYQP EYGARPLRRT IQREVDNQLS RLLLNGQIQE GGRVTVDVTD GHLEFRTDEH
P
//
