ID   S2Z3U3_9ACTN            Unreviewed;       485 AA.
AC   S2Z3U3;
DT   18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT   18-SEP-2013, sequence version 1.
DT   24-JAN-2024, entry version 34.
DE   RecName: Full=Aldehyde dehydrogenase domain-containing protein {ECO:0000259|Pfam:PF00171};
GN   ORFNames=HMPREF1211_05653 {ECO:0000313|EMBL:EPD58714.1};
OS   Streptomyces sp. HGB0020.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1078086 {ECO:0000313|EMBL:EPD58714.1, ECO:0000313|Proteomes:UP000014410};
RN   [1] {ECO:0000313|EMBL:EPD58714.1, ECO:0000313|Proteomes:UP000014410}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HGB0020 {ECO:0000313|EMBL:EPD58714.1,
RC   ECO:0000313|Proteomes:UP000014410};
RG   The Broad Institute Genomics Platform;
RA   Earl A., Ward D., Feldgarden M., Gevers D., Schmidt T.M., Dai D., Dover J.,
RA   Kim K., Walker B., Young S., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA   Abouelleil A., Allen A.W., Alvarado L., Arachchi H.M., Berlin A.M.,
RA   Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA   Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA   Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sisk P.,
RA   Sykes S., Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Streptomyces sp. HGB0020.";
RL   Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC       {ECO:0000256|RuleBase:RU003345}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EPD58714.1}.
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DR   EMBL; AGER01000023; EPD58714.1; -; Genomic_DNA.
DR   RefSeq; WP_016435555.1; NZ_KE150428.1.
DR   AlphaFoldDB; S2Z3U3; -.
DR   STRING; 1078086.HMPREF1211_05653; -.
DR   PATRIC; fig|1078086.3.peg.5705; -.
DR   HOGENOM; CLU_005391_0_2_11; -.
DR   OrthoDB; 6882680at2; -.
DR   Proteomes; UP000014410; Unassembled WGS sequence.
DR   GO; GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   CDD; cd07139; ALDH_AldA-Rv0768; 1.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR029510; Ald_DH_CS_GLU.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   PANTHER; PTHR42804; ALDEHYDE DEHYDROGENASE; 1.
DR   PANTHER; PTHR42804:SF1; ALDEHYDE DEHYDROGENASE-RELATED; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   SUPFAM; SSF53720; ALDH-like; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000256|RuleBase:RU003345};
KW   Reference proteome {ECO:0000313|Proteomes:UP000014410}.
FT   DOMAIN          24..477
FT                   /note="Aldehyde dehydrogenase"
FT                   /evidence="ECO:0000259|Pfam:PF00171"
FT   ACT_SITE        253
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10007"
SQ   SEQUENCE   485 AA;  52112 MW;  F50924BAEBE91841 CRC64;
     MTELVEHGQL FIGGELTDPL GTDVIEVISP HTEEVFGRVP HASKADVDRA VETARRAFDD
     GPWARMSLDE RIEVVTRIKD AIAVRHEEIA RTISSENGSP YSWSVLAQAL GAMMVWDAAI
     TVARGFTYEE TRDGALGKIM VRREPVGVVA AVVPWNVPQF VAAAKLAPAL LTGCSVILKP
     SPESPLDAYI LADITREAGL PEGVLSILPA DREVSEYLVG HPGVDKVSFT GSVAAGKRVM
     EVASRHLTRV TLELGGKSAA VVLPDADVES TVAGVVPAAW MNNGQACVAQ TRILLPRSRY
     DEFAEAFAAA AGALVVGDPL DAATQVGPLV ARRQQQRNLD YIRIGQEEGA KILTGGGRPP
     GLDRGWYVEP TLFGDVDNSM RIAREEIFGP VICLLPYGDE SDAVKIANDS DYGLSGSVWT
     ADVEHGIDVA RRVRTGTYSV NTFSLDMLGP FGGYKNSGLG REFGPEGYGE YLEYKMIHLP
     AGWEA
//