ID S2ZE51_9ACTN Unreviewed; 812 AA.
AC S2ZE51;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=Dimethylglycine oxidase {ECO:0008006|Google:ProtNLM};
GN ORFNames=HMPREF1211_03903 {ECO:0000313|EMBL:EPD62269.1};
OS Streptomyces sp. HGB0020.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1078086 {ECO:0000313|EMBL:EPD62269.1, ECO:0000313|Proteomes:UP000014410};
RN [1] {ECO:0000313|EMBL:EPD62269.1, ECO:0000313|Proteomes:UP000014410}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HGB0020 {ECO:0000313|EMBL:EPD62269.1,
RC ECO:0000313|Proteomes:UP000014410};
RG The Broad Institute Genomics Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Schmidt T.M., Dai D., Dover J.,
RA Kim K., Walker B., Young S., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA Abouelleil A., Allen A.W., Alvarado L., Arachchi H.M., Berlin A.M.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sisk P.,
RA Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Streptomyces sp. HGB0020.";
RL Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the GcvT family.
CC {ECO:0000256|ARBA:ARBA00008609}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EPD62269.1}.
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DR EMBL; AGER01000015; EPD62269.1; -; Genomic_DNA.
DR RefSeq; WP_016433856.1; NZ_KE150427.1.
DR AlphaFoldDB; S2ZE51; -.
DR STRING; 1078086.HMPREF1211_03903; -.
DR PATRIC; fig|1078086.3.peg.3950; -.
DR HOGENOM; CLU_007884_11_2_11; -.
DR OrthoDB; 2055370at2; -.
DR Proteomes; UP000014410; Unassembled WGS sequence.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR Gene3D; 2.40.30.110; Aminomethyltransferase beta-barrel domains; 1.
DR Gene3D; 3.30.70.1400; Aminomethyltransferase beta-barrel domains; 1.
DR Gene3D; 3.30.9.10; D-Amino Acid Oxidase, subunit A, domain 2; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR006076; FAD-dep_OxRdtase.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR032503; FAO_M.
DR InterPro; IPR028896; GCST/YgfZ/DmdA.
DR InterPro; IPR013977; GCV_T_C.
DR InterPro; IPR006222; GCV_T_N.
DR InterPro; IPR029043; GcvT/YgfZ_C.
DR InterPro; IPR027266; TrmE/GcvT_dom1.
DR PANTHER; PTHR43757; AMINOMETHYLTRANSFERASE; 1.
DR PANTHER; PTHR43757:SF2; AMINOMETHYLTRANSFERASE, MITOCHONDRIAL; 1.
DR Pfam; PF01266; DAO; 1.
DR Pfam; PF16350; FAO_M; 1.
DR Pfam; PF01571; GCV_T; 1.
DR Pfam; PF08669; GCV_T_C; 1.
DR SUPFAM; SSF101790; Aminomethyltransferase beta-barrel domain; 1.
DR SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR SUPFAM; SSF103025; Folate-binding domain; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000014410}.
FT DOMAIN 5..367
FT /note="FAD dependent oxidoreductase"
FT /evidence="ECO:0000259|Pfam:PF01266"
FT DOMAIN 374..426
FT /note="FAD dependent oxidoreductase central"
FT /evidence="ECO:0000259|Pfam:PF16350"
FT DOMAIN 429..702
FT /note="Aminomethyltransferase folate-binding"
FT /evidence="ECO:0000259|Pfam:PF01571"
FT DOMAIN 725..804
FT /note="Glycine cleavage T-protein C-terminal barrel"
FT /evidence="ECO:0000259|Pfam:PF08669"
SQ SEQUENCE 812 AA; 89120 MW; 7D9A3C9A464763FE CRC64;
MAGPRVVIIG AGVVGAALAD EVSARGWTDV TVVDQGPLPA TGGSSSHAPG LVFQTNSSKT
MTELARYTVE KFCSLDVDGK PCFLQVGGLE VATSPERLAE LRRRHGWITA WGIEARLLTP
DECVEQHPLV DRDRVLGGLH VPTDGLAKAV LAVEAQIRRA TERGVRFLAR HEVLDIRQDD
GRVTGVVTDQ GELDADIVVC CAGIWGPRIA RMAGMNLPLT PLGHQLAWTG PVPALAGQKE
EAVRPILRHQ DADLYYRDRF DGLGIGYYGH RPMPTTADEI LSFDEAAEMP SVLKFTEEDF
EPAWAETRSL LPATQEAKIE EGINGLFSFT TDNFPLLGES PDVKGFWVAE AVWVTHSAGV
GRAMAEWLVD GHCSSFDLHE CDVNRFEPHQ LSPEYVLARD CQNFVEVYDI LHPLQPSGDP
RPIRTSPFHP RQQEHGAFFL EANGWERPQW YEANAHLVEG RSIPTPNDWA ARYWSPIVGA
EAQVTRETVA LYDMTALKRL EVTGPGAAAF LEGLVTGKVA KSVGSVTYTL LLDRDGGIRS
DITVARLARD RFQVGANGNL DLDWFTRHLP ADGTVQVRDI TPGTCCIGLW GPLARKVLQP
LTDDDFSNDG LKYFRGKQAY IGSVPVTALR LSYVGELGWE LYTTADQGLK LWDTLWEAAR
PLGGIIAGRG AFNSLRLEKG YRSFGADMTY EHDPYEAGVG FAVKLDKGDF VGKPALQRRK
ADVRRKLTCL TIDDPRSVVM GKEPVYDGER AVGYVTSAAY GYTIGKGIAY AWLPVEVAVP
GARVRIGYFD QRVEAVVAEE PLFDPSMSRL RG
//
