ID S31D3_HUMAN Reviewed; 917 AA.
AC P0C874;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 02-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 86.
DE RecName: Full=Spermatogenesis-associated protein 31D3;
DE AltName: Full=Protein FAM75D3;
GN Name=SPATA31D3; Synonyms=FAM75D3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
CC -!- FUNCTION: May play a role in spermatogenesis. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the SPATA31 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AK126070; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=AK308327; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK126070; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AK308327; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AL158154; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS83380.1; -.
DR RefSeq; NP_997299.2; NM_207416.2.
DR AlphaFoldDB; P0C874; -.
DR BioGRID; 133259; 2.
DR STRING; 9606.ENSP00000488117; -.
DR GlyGen; P0C874; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; P0C874; -.
DR PhosphoSitePlus; P0C874; -.
DR BioMuta; SPATA31D3; -.
DR DMDM; 205831115; -.
DR MassIVE; P0C874; -.
DR PeptideAtlas; P0C874; -.
DR ProteomicsDB; 52409; -.
DR DNASU; 389762; -.
DR Ensembl; ENST00000445385.3; ENSP00000488117.1; ENSG00000186788.14.
DR GeneID; 389762; -.
DR KEGG; hsa:389762; -.
DR MANE-Select; ENST00000445385.3; ENSP00000488117.1; NM_207416.3; NP_997299.2.
DR AGR; HGNC:38603; -.
DR CTD; 389762; -.
DR GeneCards; SPATA31D3; -.
DR HGNC; HGNC:38603; SPATA31D3.
DR HPA; ENSG00000186788; Tissue enriched (testis).
DR neXtProt; NX_P0C874; -.
DR VEuPathDB; HostDB:ENSG00000186788; -.
DR GeneTree; ENSGT00950000183043; -.
DR HOGENOM; CLU_007854_1_0_1; -.
DR InParanoid; P0C874; -.
DR OMA; FLMCKES; -.
DR OrthoDB; 4614846at2759; -.
DR BioGRID-ORCS; 389762; 5 hits in 217 CRISPR screens.
DR GenomeRNAi; 389762; -.
DR Pharos; P0C874; Tdark.
DR PRO; PR:P0C874; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; P0C874; Protein.
DR Bgee; ENSG00000186788; Expressed in male germ line stem cell (sensu Vertebrata) in testis and 6 other cell types or tissues.
DR Genevisible; P0C874; HS.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR InterPro; IPR039509; SPATA31.
DR InterPro; IPR027970; SPATA31F3-like.
DR PANTHER; PTHR21859; ACROSOME-SPECIFIC PROTEIN; 1.
DR PANTHER; PTHR21859:SF50; SPERMATOGENESIS-ASSOCIATED PROTEIN 31D3-RELATED; 1.
DR Pfam; PF15371; DUF4599; 1.
DR Pfam; PF14650; FAM75; 1.
PE 2: Evidence at transcript level;
KW Differentiation; Membrane; Reference proteome; Spermatogenesis;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..917
FT /note="Spermatogenesis-associated protein 31D3"
FT /id="PRO_0000349241"
FT TRANSMEM 29..49
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 55..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 152..195
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 773..797
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 63..77
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 152..183
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 780..797
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 389
FT /note="G -> R (in Ref. 1; AK308327)"
FT /evidence="ECO:0000305"
FT CONFLICT 541
FT /note="S -> F (in Ref. 1; AK308327)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 917 AA; 102419 MW; DB9FB7B800EA3322 CRC64;
MENILCFLNS YTETGLSPDS HCLDIDLNFI CLSGLGLFIL YLFYMVLTLY SSPTEKNNDT
QKHQGRARRK RKSVTFKDRK SLQKEAEEER KLHSFLKSFG PPVSCSPLGQ HHDTTLFRRL
LCPDPVCRVC NRATADIQRL LSWESLKDAA PSVSPLASSA SGAESSFTLA STPSATTPED
LILSSRPKPS PPPPLILSPD LITTLADLFS PSPLRDPLPP QPVSPLDSKF PIDHSPPQQL
PFPLLPPHHI ERVEPSLQPE ASLSLNTIFS FGSTLCQDIS QAVNRTDSCA RHHGPPTPSA
LPPEDCTVTQ SKSNLTVLKT FPEMLSLGGS GGSSTSAPTT KGIDHSCPAS SEFSWWQPHA
KDSFSSNFVP SDFMEELLTL HSSEASLGGH SVANIIQPVN ISFLSHDIPA LLERQVKRRG
DFLMWKENGK KPGSFPTQLR PNYQLNSSRN MLTSTAVKHD LAESFPFWAS KGKLEWQHIH
QQPPYSKCFE DHLEQKYVQL FWGLPSLHSE SLHPTVFVQH GRSSMFVFFN GITNTSMSHE
SPVLPPPQPL FLPSTQPLPL PQTLPRGQSL HLTQVKSLAQ PQSPFPALPP SPLFLIRVCG
VCFHRPQNEA RSLMPSEINH LEWNVLQKVQ ESVWGLPSVV QKSQEDFCPP APNPVLVRKS
FKVHVPISII PGDFPLSSEV RKKLEQHIRK RLIQRRWGLP RRIHESLSLL RPQNKISELS
VSESIHGPLN ISLVEGQRCN VLKKSASSFP RSFHERSSNM LSMENVGNYQ GCSQETAPKN
HLLHDPETSS EEDLRSNSER DLGTHMMHLS GNDSGVRLGQ KQLENALTVH LSKKFEEINE
GRMPGTVHSS WHSVKQTICL PEKSHSQIKH RNLAALVSED HRVDTSQEMS FLSSNKQKML
EAHIKSFHMK PILNLSI
//
