ID S35B1_XENTR Reviewed; 323 AA.
AC Q8AXS6; Q28HJ6;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 22-NOV-2005, sequence version 2.
DT 27-MAR-2024, entry version 85.
DE RecName: Full=Solute carrier family 35 member B1;
GN Name=slc35b1; ORFNames=TTpA002i04.1;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND GENE FAMILY.
RX PubMed=12770764; DOI=10.1016/s0300-9084(03)00046-4;
RA Martinez-Duncker I., Mollicone R., Codogno P., Oriol R.;
RT "The nucleotide-sugar transporter family: a phylogenetic approach.";
RL Biochimie 85:245-260(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Tadpole;
RG Sanger Xenopus tropicalis EST/cDNA project;
RL Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Probable sugar transporter. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305};
CC Multi-pass membrane protein {ECO:0000305}.
CC -!- DOMAIN: The di-lysine motif confers endoplasmic reticulum localization
CC for type I membrane proteins. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the nucleotide-sugar transporter family. SLC35B
CC subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAD54627.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AJ512377; CAD54627.1; ALT_INIT; mRNA.
DR EMBL; CR760858; CAJ82891.1; -; mRNA.
DR RefSeq; NP_989418.1; NM_204087.1.
DR AlphaFoldDB; Q8AXS6; -.
DR SMR; Q8AXS6; -.
DR STRING; 8364.ENSXETP00000049605; -.
DR PaxDb; 8364-ENSXETP00000033116; -.
DR GeneID; 395058; -.
DR KEGG; xtr:395058; -.
DR AGR; Xenbase:XB-GENE-972777; -.
DR CTD; 10237; -.
DR Xenbase; XB-GENE-972777; slc35b1.
DR eggNOG; KOG1580; Eukaryota.
DR HOGENOM; CLU_036019_1_0_1; -.
DR InParanoid; Q8AXS6; -.
DR OrthoDB; 614761at2759; -.
DR Proteomes; UP000008143; Chromosome 10.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR InterPro; IPR013657; SCL35B1-4/HUT1.
DR PANTHER; PTHR10778; SOLUTE CARRIER FAMILY 35 MEMBER B; 1.
DR PANTHER; PTHR10778:SF10; SOLUTE CARRIER FAMILY 35 MEMBER B1; 1.
DR Pfam; PF08449; UAA; 1.
DR SUPFAM; SSF103481; Multidrug resistance efflux transporter EmrE; 2.
PE 2: Evidence at transcript level;
KW Endoplasmic reticulum; Membrane; Reference proteome; Sugar transport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..323
FT /note="Solute carrier family 35 member B1"
FT /id="PRO_0000213372"
FT TRANSMEM 15..35
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 51..71
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 85..105
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 136..156
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 169..189
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 205..225
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 253..273
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 286..306
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOTIF 319..323
FT /note="Di-lysine motif"
SQ SEQUENCE 323 AA; 35582 MW; 5ACDE8AA88741A4C CRC64;
MAAGGAQGSG GARLLVCFLG VFVCYFYYGI LQETITRGTY GEGEKQEKFR FALSLVFVQC
IVNALFAKLL IQFFDSGKTD RTQSWLYAAC SLSYLGAMVS SNSALQFVNY PTQVLGKSCK
PIPVMLLGVT LLRKKYPLSK YLCVLLIVLG VALFMYKPKN TGSGGDEHTF GYGELLLLLS
LTLDGLTGVS QDHMRAHFQT GSNHMMLYIN LWSSLFLGAG IVFTGELWDF LSFTERYPSI
VYNIMLFSLT SALGQTFIFM TVVYFGPLTC SIITTTRKFF TILASVILFS NPISSIQWVG
TILVFLGLGL DATYGKGSKK PSH
//
