ID S3C2Q5_OPHP1 Unreviewed; 735 AA.
AC S3C2Q5;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=Probable Xaa-Pro aminopeptidase P {ECO:0000256|ARBA:ARBA00020658};
DE AltName: Full=Prolidase {ECO:0000256|ARBA:ARBA00032413};
GN ORFNames=F503_03484 {ECO:0000313|EMBL:EPE07057.1};
OS Ophiostoma piceae (strain UAMH 11346) (Sap stain fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Ophiostomatales; Ophiostomataceae; Ophiostoma.
OX NCBI_TaxID=1262450 {ECO:0000313|EMBL:EPE07057.1, ECO:0000313|Proteomes:UP000016923};
RN [1] {ECO:0000313|EMBL:EPE07057.1, ECO:0000313|Proteomes:UP000016923}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UAMH 11346 {ECO:0000313|EMBL:EPE07057.1,
RC ECO:0000313|Proteomes:UP000016923};
RX PubMed=23725015; DOI=10.1186/1471-2164-14-373;
RA Haridas S., Wang Y., Lim L., Massoumi Alamouti S., Jackman S., Docking R.,
RA Robertson G., Birol I., Bohlmann J., Breuil C.;
RT "The genome and transcriptome of the pine saprophyte Ophiostoma piceae, and
RT a comparison with the bark beetle-associated pine pathogen Grosmannia
RT clavigera.";
RL BMC Genomics 14:373-373(2013).
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- SIMILARITY: Belongs to the peptidase M24B family.
CC {ECO:0000256|ARBA:ARBA00008766, ECO:0000256|RuleBase:RU000590}.
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DR EMBL; KE148152; EPE07057.1; -; Genomic_DNA.
DR AlphaFoldDB; S3C2Q5; -.
DR STRING; 1262450.S3C2Q5; -.
DR VEuPathDB; FungiDB:F503_03484; -.
DR eggNOG; KOG2413; Eukaryota.
DR HOGENOM; CLU_011781_2_1_1; -.
DR OMA; EPGMILS; -.
DR OrthoDB; 869at2759; -.
DR Proteomes; UP000016923; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0070006; F:metalloaminopeptidase activity; IEA:InterPro.
DR CDD; cd01085; APP; 1.
DR Gene3D; 3.90.230.10; Creatinase/methionine aminopeptidase superfamily; 1.
DR Gene3D; 3.40.350.10; Creatinase/prolidase N-terminal domain; 2.
DR InterPro; IPR029149; Creatin/AminoP/Spt16_NTD.
DR InterPro; IPR036005; Creatinase/aminopeptidase-like.
DR InterPro; IPR000587; Creatinase_N.
DR InterPro; IPR000994; Pept_M24.
DR InterPro; IPR033740; Pept_M24B.
DR InterPro; IPR032416; Peptidase_M24_C.
DR InterPro; IPR001131; Peptidase_M24B_aminopep-P_CS.
DR PANTHER; PTHR43763; XAA-PRO AMINOPEPTIDASE 1; 1.
DR PANTHER; PTHR43763:SF6; XAA-PRO AMINOPEPTIDASE 1; 1.
DR Pfam; PF01321; Creatinase_N; 1.
DR Pfam; PF16189; Creatinase_N_2; 1.
DR Pfam; PF00557; Peptidase_M24; 1.
DR Pfam; PF16188; Peptidase_M24_C; 1.
DR SUPFAM; SSF55920; Creatinase/aminopeptidase; 1.
DR SUPFAM; SSF53092; Creatinase/prolidase N-terminal domain; 1.
DR PROSITE; PS00491; PROLINE_PEPTIDASE; 1.
PE 3: Inferred from homology;
KW Aminopeptidase {ECO:0000313|EMBL:EPE07057.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU000590}; Protease {ECO:0000313|EMBL:EPE07057.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000016923}.
FT DOMAIN 115..249
FT /note="Creatinase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01321"
FT DOMAIN 444..661
FT /note="Peptidase M24"
FT /evidence="ECO:0000259|Pfam:PF00557"
FT DOMAIN 673..734
FT /note="Peptidase M24 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF16188"
FT REGION 63..104
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 80..100
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 735 AA; 80129 MW; 1DA77D763BC559FE CRC64;
MSFSSSSTVS RALPRIVGAH TQSITKSATL RIAKLAALPK AAILSKPVSP SVTELPCSSL
YHQRRIGPLR SPTSPYQRPP SSNPRRYAHT QASSARPEES TTPVAEMETI ATGERLEKLR
QLMVENKIDL YIIPSEDAHS SEYIAPCDGR REFISGFSGS AGCAVVSFDK AVVATDGRYF
NQAAKQLDNN WTLLKQGIQD VPTWQEWTAS ESVGGKVVGV DPTLLASSTA KKLAEKIKRS
GGKDLVAVST NLVDSVWGTE RPPHPTEPII LLDSTKFAGK DTTTKLTELR AELEKKSGAG
FVVSLLDEVA WLFNLRGNDI PYNPVFFSYA IVTNDDAILY VDSTKLNSEC KASLEANQVT
IKPYDAIFAD SKILGAALAA SKEASVEDAE GEKDKSLPAD GKKFLLSNRT SWALVLALGG
EDFVEEVRSP IGDAKAVKND VELEGMRQCH IRDGVALIQY LAWLEDQLTS GVALDEVEAA
DKLEALRSVQ DHYVGLSFPT ISSTGANAAV IHYQPERGSC SPLDVNEIYL CDSGAQYYDG
TTDTTRTVHF GTPTDAERKA YTLVLKGNIA LDVAVFPKGT TGFALDAFAR QFLWSEGLDY
RHGTGHGVGS FLNVHEGPIG IGTRKQYAEV SLATGNVTSI EPGYYEDGSY GIRIENMVIV
GEVKTTHTFG DKPYLGFEHV TMVPYCRALI DRELLSPREI KWLNDYHVEI VAKTKSLLGD
DKVALAWLEK ETQPY
//
