ID S3C491_OPHP1 Unreviewed; 824 AA.
AC S3C491;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Hormone-sensitive lipase {ECO:0000313|EMBL:EPE07617.1};
GN ORFNames=F503_00339 {ECO:0000313|EMBL:EPE07617.1};
OS Ophiostoma piceae (strain UAMH 11346) (Sap stain fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Ophiostomatales; Ophiostomataceae; Ophiostoma.
OX NCBI_TaxID=1262450 {ECO:0000313|EMBL:EPE07617.1, ECO:0000313|Proteomes:UP000016923};
RN [1] {ECO:0000313|EMBL:EPE07617.1, ECO:0000313|Proteomes:UP000016923}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UAMH 11346 {ECO:0000313|EMBL:EPE07617.1,
RC ECO:0000313|Proteomes:UP000016923};
RX PubMed=23725015; DOI=10.1186/1471-2164-14-373;
RA Haridas S., Wang Y., Lim L., Massoumi Alamouti S., Jackman S., Docking R.,
RA Robertson G., Birol I., Bohlmann J., Breuil C.;
RT "The genome and transcriptome of the pine saprophyte Ophiostoma piceae, and
RT a comparison with the bark beetle-associated pine pathogen Grosmannia
RT clavigera.";
RL BMC Genomics 14:373-373(2013).
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DR EMBL; KE148150; EPE07617.1; -; Genomic_DNA.
DR AlphaFoldDB; S3C491; -.
DR STRING; 1262450.S3C491; -.
DR VEuPathDB; FungiDB:F503_00339; -.
DR eggNOG; KOG4388; Eukaryota.
DR HOGENOM; CLU_003590_1_0_1; -.
DR OMA; NMYDATY; -.
DR OrthoDB; 37251at2759; -.
DR Proteomes; UP000016923; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 2.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR013094; AB_hydrolase_3.
DR InterPro; IPR033140; Lipase_GDXG_put_SER_AS.
DR PANTHER; PTHR23025:SF3; HORMONE-SENSITIVE LIPASE; 1.
DR PANTHER; PTHR23025; TRIACYLGLYCEROL LIPASE; 1.
DR Pfam; PF07859; Abhydrolase_3; 2.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR PROSITE; PS01174; LIPASE_GDXG_SER; 1.
PE 4: Predicted;
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000016923}.
FT DOMAIN 226..395
FT /note="Alpha/beta hydrolase fold-3"
FT /evidence="ECO:0000259|Pfam:PF07859"
FT DOMAIN 485..573
FT /note="Alpha/beta hydrolase fold-3"
FT /evidence="ECO:0000259|Pfam:PF07859"
FT REGION 408..486
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 655..824
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 412..434
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 435..464
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 693..708
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 710..729
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 745..777
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 779..806
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 303
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10038"
SQ SEQUENCE 824 AA; 91441 MW; E8DEDF8B1827A9DA CRC64;
MIDHVLGRPS IKSRRLQVLA VLAFWTAYLA RGNKNGPPGT QSFSKILSKK LTAWQIVLLT
MLYLYAARNF STLVGLASPD PLANMYDPSF FRATWILTAL DAGFWTAMKI RTKWVRELAS
IVFSGFYMVA AEKADEKVRK VRGNLTVEHL RVSWNKGTTP YIRFLQGLTS PRLTRWPPRL
LRIPRPNTTG SSDKHHPPIM AWLYYDGSLE QLRTSGIDRV IMDIPGGGFV AMDPRCNDDR
LLSWAVKTGL PVVSLDYKKA PEYPFPYALN ECYDAYSTLV QTRGRCIGLA AESPVRIVVA
GDSAGGNLAT AMTLMLAQQS GLSSWDSSSD NKQSRLPLPD GLILVYPCMD VNIGNWMSDE
QMALMQDRRT RAANRNVLRR KAKQYSDIAG TPHETDDEDF LAMTPAVKTR AGKKTQEVRQ
EDADADDEFT KSQGDRARTP QPAYSHVNLS TYSRPQTPAT EKPPIQFTPL TDVSGAAPTP
SSPYHPVPMS TRLATASTIS YFNDRVLTPE MMRAMIILYV GPHNRPDFSQ DYLLSPILAP
DLLLAHFPKT YFLTGERDPL VDDTVIFSGR LRRIKMAYHA SGGRRVEYRE SDAAFCAEDD
SFDDRRDVAE VMLIPGVSHG FLQFPAVYPP AWQWFQRSAQ WIEDVFTHAE EIRETRTRAA
SSNTKDANES PAQARRGRAP SRPQPLQGEE EVTPSAEIRE KKGKQLVVDT GKSDTVSQAR
PQLSARTESS GDEAPLEMMR MTKSKTAKES TSAADSPATT SSSASSTAAT TPNARPSAET
KAKKPKGPRR PKDDSSLVKL KSSDDLLGRR MQGIVGSLSG VTEE
//
