ID S3CC01_OPHP1 Unreviewed; 1026 AA.
AC S3CC01;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 24-JAN-2024, entry version 50.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN ORFNames=F503_06489 {ECO:0000313|EMBL:EPE03783.1};
OS Ophiostoma piceae (strain UAMH 11346) (Sap stain fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Ophiostomatales; Ophiostomataceae; Ophiostoma.
OX NCBI_TaxID=1262450 {ECO:0000313|EMBL:EPE03783.1, ECO:0000313|Proteomes:UP000016923};
RN [1] {ECO:0000313|EMBL:EPE03783.1, ECO:0000313|Proteomes:UP000016923}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UAMH 11346 {ECO:0000313|EMBL:EPE03783.1,
RC ECO:0000313|Proteomes:UP000016923};
RX PubMed=23725015; DOI=10.1186/1471-2164-14-373;
RA Haridas S., Wang Y., Lim L., Massoumi Alamouti S., Jackman S., Docking R.,
RA Robertson G., Birol I., Bohlmann J., Breuil C.;
RT "The genome and transcriptome of the pine saprophyte Ophiostoma piceae, and
RT a comparison with the bark beetle-associated pine pathogen Grosmannia
RT clavigera.";
RL BMC Genomics 14:373-373(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- SIMILARITY: Belongs to the RuvB family.
CC {ECO:0000256|ARBA:ARBA00007519}.
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DR EMBL; KE148165; EPE03783.1; -; Genomic_DNA.
DR AlphaFoldDB; S3CC01; -.
DR STRING; 1262450.S3CC01; -.
DR VEuPathDB; FungiDB:F503_06489; -.
DR eggNOG; KOG1942; Eukaryota.
DR eggNOG; KOG4510; Eukaryota.
DR HOGENOM; CLU_295123_0_0_1; -.
DR OMA; PRMTEIT; -.
DR OrthoDB; 5479950at2759; -.
DR Proteomes; UP000016923; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0008094; F:ATP-dependent activity, acting on DNA; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.50.360; RuvB-like helicase, domain II; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR000620; EamA_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR027238; RuvB-like.
DR InterPro; IPR041048; RuvB-like_C.
DR InterPro; IPR042487; RuvBL1/2_DNA/RNA_bd_dom.
DR InterPro; IPR010339; TIP49_P-loop.
DR PANTHER; PTHR11093:SF6; RUVB-LIKE 1; 1.
DR PANTHER; PTHR11093; RUVB-RELATED REPTIN AND PONTIN; 1.
DR Pfam; PF00892; EamA; 1.
DR Pfam; PF06068; TIP49; 1.
DR Pfam; PF17856; TIP49_C; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF103481; Multidrug resistance efflux transporter EmrE; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000016923};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 144..165
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 177..198
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 210..230
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 242..259
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 271..293
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 348..371
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 383..402
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 417..437
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 474..492
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 635..924
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 1..76
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 537..606
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 23..47
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 48..63
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 560..578
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1026 AA; 111796 MW; 963B9089BCDF5E18 CRC64;
MPPYLQIPQT PSAKAQFDSR LDELPSGSIS GSDRAASELN LHRPTSPSDR TADAEEIAKH
RRKTASPATP FLYSNHGNIN QLRPPDAFHR LSIGSISDAG YGPSVLPSVY QTSYPTGGAA
AAAAPATPSR VPAFMLRFWN RNRAVLFVFF AQLFGALMNL FARLLELDVD DHAFHPVQLL
FMRMIMTTCA SCLYMWYYKV PNFPLGPPGV RWLLVIRGLT GFFGIFGMWY SMMYLPLAEA
TVFTFLSPSV TGYICHVLLK DPFTRREQIA SVVAFSGIIL ITRPLSFISH SAVQVNEEDT
MDAALNTTAL VSGTVSAAVA MIREVVNETA SKIAAADSEE GATTIQRLVA IVVALVGVLG
GSSAFTSIRA IGTRAHPLIS VNYFSTWCTV VTGTVLFCAP MLDIGQPYLQ FALPHSIRQW
IFLLFICVCG FCTQFLATTG LGLERSNRAT AMVYTQMLFA AGFDRFVFGH EMGTTSLVGC
GLVIGSALWA ALATKPPPMR VMTAATAAPT TDIEIGVIGT QRDNHPLTEH DIAREPRAEG
VPMLAAEDSD EDDEDLLERS TPLNSQPRNT AKMVQISEVK NSSRDHRTSS HTHIKGLGLK
SDGTAERQSS GFVGQASARE ACGVVVDLIR AHKMAGRGVM LAGGPGTGKT ALALAISQEL
GTKIPFCPIV GSEVYSAEVK KTEMLMENFR RAIGLKVRET KEVYEGEVTE LTPEEAENPL
GGYGKTISTL LIGLKSAKGQ KKLRLDPSIY EAIQKERVTV GDVIYIEANT GACKRVGRSD
AYATEFDLEA EEYVPIPKGE VHKKKEIVQD VTLHDLDMAN ARPQGGQDIM SMMGQLMKPR
MTEITDKLRA EINKIVSMYI DQGVAELVPG VLFIDEAHML DLECFTYLNR ALESPIAPIV
VLASNRGMTT IRGTDDLVAA HGIPPDFLAR LLIIPTHAYD ADEIKRIVRI RSTTEGTPLT
EAAIDKIAEE GVRISLRYCL QLLAPSSILA RVNGRKEIDV RDVEECEELF LDATRSAAKL
SGEFMA
//
