ID   S3CHH3_GLAL2            Unreviewed;      1721 AA.
AC   S3CHH3;
DT   18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT   18-SEP-2013, sequence version 1.
DT   27-MAR-2024, entry version 42.
DE   SubName: Full=GTPase activation, GAP {ECO:0000313|EMBL:EPE24739.1};
GN   ORFNames=GLAREA_08592 {ECO:0000313|EMBL:EPE24739.1};
OS   Glarea lozoyensis (strain ATCC 20868 / MF5171).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC   Helotiales; Helotiaceae; Glarea.
OX   NCBI_TaxID=1116229 {ECO:0000313|EMBL:EPE24739.1, ECO:0000313|Proteomes:UP000016922};
RN   [1] {ECO:0000313|EMBL:EPE24739.1, ECO:0000313|Proteomes:UP000016922}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 20868 / MF5171 {ECO:0000313|Proteomes:UP000016922};
RX   PubMed=23688303; DOI=10.1186/1471-2164-14-339;
RA   Chen L., Yue Q., Zhang X., Xiang M., Wang C., Li S., Che Y.,
RA   Ortiz-Lopez F.J., Bills G.F., Liu X., An Z.;
RT   "Genomics-driven discovery of the pneumocandin biosynthetic gene cluster in
RT   the fungus Glarea lozoyensis.";
RL   BMC Genomics 14:339-339(2013).
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DR   EMBL; KE145373; EPE24739.1; -; Genomic_DNA.
DR   RefSeq; XP_008088827.1; XM_008090636.1.
DR   STRING; 1116229.S3CHH3; -.
DR   GeneID; 19467640; -.
DR   KEGG; glz:GLAREA_08592; -.
DR   eggNOG; KOG2128; Eukaryota.
DR   HOGENOM; CLU_000972_1_1_1; -.
DR   OMA; KGVLVHW; -.
DR   OrthoDB; 12619at2759; -.
DR   Proteomes; UP000016922; Unassembled WGS sequence.
DR   GO; GO:0015629; C:actin cytoskeleton; IEA:UniProt.
DR   GO; GO:0006996; P:organelle organization; IEA:UniProt.
DR   CDD; cd21206; CH_IQGAP; 1.
DR   CDD; cd05127; RasGAP_IQGAP_like; 1.
DR   Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR   InterPro; IPR001715; CH_dom.
DR   InterPro; IPR036872; CH_dom_sf.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR000593; RasGAP_C.
DR   InterPro; IPR001936; RasGAP_dom.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   PANTHER; PTHR14149:SF14; PATTERNED EXPRESSION SITE; 1.
DR   PANTHER; PTHR14149; RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF; 1.
DR   Pfam; PF00307; CH; 1.
DR   Pfam; PF00616; RasGAP; 1.
DR   Pfam; PF03836; RasGAP_C; 1.
DR   SMART; SM00033; CH; 1.
DR   SMART; SM00015; IQ; 8.
DR   SMART; SM00323; RasGAP; 1.
DR   SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   SUPFAM; SSF143885; RGC domain-like; 1.
DR   PROSITE; PS50021; CH; 1.
DR   PROSITE; PS50096; IQ; 8.
DR   PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000016922}.
FT   DOMAIN          332..438
FT                   /note="Calponin-homology (CH)"
FT                   /evidence="ECO:0000259|PROSITE:PS50021"
FT   DOMAIN          1085..1301
FT                   /note="Ras-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50018"
FT   REGION          1..153
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          166..185
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          220..241
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..60
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        121..153
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1721 AA;  196560 MW;  9ECF58C26402050D CRC64;
     MSYRPPLRQT QTVDYSGHLS PTKRQPSNAS TVSSAYSNSS GHYELSRTST ISSTASSGYG
     HKRGLSEAGG MRSPGIENRI GRGVRDSTES SPESPYKSAR QSLRPLPQPP GPPPIDRNAS
     LYNHTRGQSV DTFRHSYGEN PINKHASATL PSTRERSIET FRHSYGENPV DKHASATPPA
     TRGHTVESFR SSYGEHPSNK QISAIPSSIR PNSLLLSRAD SVSRPRVSGR SQTIQGLPQL
     QTPDLLSLQR SSTSQLRTLS QFAETASSED FSITSPAQEV VGLHGRRRLQ KGDNTRGGQS
     AVALSRGNGG YSWEGRNWMD KQRQFLQAYE YLCHIGEAKE WIEDILKREI PPIVQLEEAL
     RDGVTLAEIV DSLHPERRLR IFRSPKLQFR HSDNIAIFFR YLAEVELPDL FRFELIDLYE
     KKNIPKVIYC IHALSWLLFR KGIVDFRIGN LVGQLEFEHH ELEAMQKGLD KAGISMPSFG
     NMGADFGVEP IPEPEPEPVE SEEDRIDREL GENELAITEL QAQIRGAAAR MRCTEIMEGL
     WNSEDMLVHL QSRIRGDMAR QIAEYRLNMY RFAVDLQSGA RGLLVRRRMS SRESFWKSRE
     GDVILLQSLT RAKKARDEVR MMKSLLHREE HGISELQASI RGFLSRNVMA AQKRDTKNSS
     GPVKELQATI RGMLLRKSIA EDNEKLWLEE SSISALQAMS KALLIRNQIS RQRDALEAFE
     PVWSSLQAVV RANAVRLEIQ ETKHELSLCT AQIVAVQSFA RAAFKREEVS NTLSDLQEAE
     GSVLQVQNSI RGMLERKRIA ADYDQLVSQT TQITQLQSLA RGCLQREKVG AVLDELEAHS
     AAVIELQGLS RAMLLRNNVG NLLADLEAEE ESIVELQAAA KACLVRARFA EKQRFFKKNM
     EKVVKLQSFV RGKLQGEAYK SLTTGKNPPI NTVKNFVHLL NDSDFDFNEE IEFERMRKTV
     VQQVRQNEMA EQYIDQLDIK IALLVKNKIT LDEVVKHQRN FGGHSGNLLV NTTMISGNQF
     DLKALNKNSR KKLESYQQLF FTLQTQPQYL ARYFKRIREQ GTPEKDCKLI ETLMMRLFGY
     AQKRREEYYL LKLIARAARE EVESCTSIQE YLRGNFFWCK LLSNYTRSPR DRKYLRELLG
     PLIQTNIIED PALDLESDPM QIYRSAINNE ELRTGQPSQR PLDIPREVAI KDPETRDMFI
     DHLRDLREIS DQVLGALEAL LHKMPYGIRF VCQEIFDALC QQFPREPQHR LLQLVGNWLW
     KFYLQPALTS PESMGVVEKQ LTPLQKRNLG EVAKVLGQVA SGRLFGGENI YLQPLNAYVG
     DAIERIRIIF SNIISVPDAE DTFDIDEFND LYAKVKPTLY IKMADIFSIH NLVSGDLPHI
     CPNRDDMLRE MVQELGSAKN NETEMLGVTS GEIQLTLNPK LHDIEDPEAE VKALFMETKR
     CVLYIIRVQS GPNLMEILVR PITREDDHKW HCLLREEFSG GSKTRGAYSD ANTLVDIKSM
     SYKELKRTAL ENIMRLEQFG RISRHNFYQD ILNAIALDIR TKSRRRVQRQ RELEGVRLTL
     ANLTEKAEWL ESQRKSYDNY IEQAMMTLQK KGKKRFLMPF SKQYNHEREL ERSGRKPKFG
     SFKYSARTLS DKGVLVSWKG THDREWEKIN LTISCDEVGV FFIEGSKGSI QIPGASAQVP
     MDSLLAAQFA NHQYMDLFEG GMRLNVNLFL HLLYKKFYRT E
//