ID S3CIY9_GLAL2 Unreviewed; 2412 AA.
AC S3CIY9;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=THO complex subunit 2 {ECO:0000256|ARBA:ARBA00019596};
GN ORFNames=GLAREA_11780 {ECO:0000313|EMBL:EPE25199.1};
OS Glarea lozoyensis (strain ATCC 20868 / MF5171).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Helotiales; Helotiaceae; Glarea.
OX NCBI_TaxID=1116229 {ECO:0000313|EMBL:EPE25199.1, ECO:0000313|Proteomes:UP000016922};
RN [1] {ECO:0000313|EMBL:EPE25199.1, ECO:0000313|Proteomes:UP000016922}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 20868 / MF5171 {ECO:0000313|Proteomes:UP000016922};
RX PubMed=23688303; DOI=10.1186/1471-2164-14-339;
RA Chen L., Yue Q., Zhang X., Xiang M., Wang C., Li S., Che Y.,
RA Ortiz-Lopez F.J., Bills G.F., Liu X., An Z.;
RT "Genomics-driven discovery of the pneumocandin biosynthetic gene cluster in
RT the fungus Glarea lozoyensis.";
RL BMC Genomics 14:339-339(2013).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the THOC2 family.
CC {ECO:0000256|ARBA:ARBA00007857}.
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DR EMBL; KE145372; EPE25199.1; -; Genomic_DNA.
DR RefSeq; XP_008088114.1; XM_008089923.1.
DR STRING; 1116229.S3CIY9; -.
DR GeneID; 19470821; -.
DR KEGG; glz:GLAREA_11780; -.
DR eggNOG; KOG1874; Eukaryota.
DR HOGENOM; CLU_000511_1_0_1; -.
DR OMA; QERWTCI; -.
DR OrthoDB; 179356at2759; -.
DR Proteomes; UP000016922; Unassembled WGS sequence.
DR GO; GO:0000347; C:THO complex; IEA:InterPro.
DR GO; GO:0006406; P:mRNA export from nucleus; IEA:InterPro.
DR GO; GO:0006397; P:mRNA processing; IEA:InterPro.
DR InterPro; IPR040007; Tho2.
DR InterPro; IPR021418; THO_THOC2_C.
DR InterPro; IPR021726; THO_THOC2_N.
DR InterPro; IPR032302; THOC2_N.
DR PANTHER; PTHR21597:SF0; THO COMPLEX SUBUNIT 2; 1.
DR PANTHER; PTHR21597; THO2 PROTEIN; 1.
DR Pfam; PF11262; Tho2; 1.
DR Pfam; PF11732; Thoc2; 1.
DR Pfam; PF16134; THOC2_N; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000016922}.
FT DOMAIN 121..849
FT /note="THO complex subunit 2 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16134"
FT DOMAIN 851..927
FT /note="THO complex subunitTHOC2 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF11732"
FT DOMAIN 1212..1519
FT /note="THO complex subunitTHOC2 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF11262"
FT REGION 1..109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 518..537
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 554..589
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1133..1157
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1169..1191
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1538..2412
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 69..84
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 518..535
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 565..589
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1546..1581
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1588..1602
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1682..1722
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1729..1754
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1764..1778
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1834..1877
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1991..2005
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2008..2033
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2099..2138
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2166..2184
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2202..2218
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2259..2306
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2317..2406
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2412 AA; 266878 MW; 1F6BB9CC521B64F3 CRC64;
MAPAKRKTHD GRSSTDAGEN RPSPHRPGNM NLGQHDRAAD PRNNGRRRSS RGGQGGAGGG
RPNRRNEDRN NSNQFTIGAR ENQTPGPSSP PPRPQSAVQT PTATPSPVFK REVAPFDYTF
VTDERVASWS TGGRDEVAKA GIQARQDEDS MDLASVFHEL SRASLDGRID ASECGTCIKD
ILNSEPASED SSSDGSFDAH TYFLDMISMI YDAEEPPFNP ALKAFITATG ISPNLMRQKL
DAQLLQNLGL TRDTFIRVGI RQATHLLYRQ ANYNLLREES EGYSKLATEL FVSSGGSDSL
VDQATQAQAR DAFERVKGLI GTFDLDVGRV LDITFDVFAS ILIKQYKFFV MLLRASSWWP
KHDLHGEIAK FEGLPSWALP GYTESKDEEE AARLYRIKRD SAFWDRARLV GLDAFFELGG
RKVVDADSKA RLLGAKGSFD EEQDADWKWI EQTGTFPPNG NKTAAQLLGF KLRYYVSPGR
DKGEDFPANL MYLAALLIKI GFVSLRDLYP HLWPSDEQMS AVKEKKEKEL AEKSKAARGG
GAANALAMAG ALADDTIPSG GRTRDTTTKA DDVSNTEGKT EDKEKPKESA DQKSLLLINL
LTIGAIPEAL FILGRFPWIP DVFPEVIPLI NRILDHSISD VYATTRPIAS STVACSSKKF
VSPDQSGMPK GQIRLAQPPT KSLMRWPFPQ QYDDPASNTN YKFYWESWAD IIPMCQNVDD
IFTLCGTLLN YSGVNIGRHP SLLSKLARIG AMSLSNDSSK QNLDRWQDLL KRLLVPALSL
TKANTSVVNE VYNMLRYYPV TIRYTIYAEW FEGQISRLPA MKAAFAQTRL ETLSTMKRIS
KTNISSMARR LAKAAYASPG IVFSVALSQI ESYSNLTDVV VECAKYFTDL GYDVLVWSLM
SSLGGKDRNR NNSEFALLPS RWLIALSKFS GKVYKRYSIM NLSPIIQYIN HQLYRGNATD
LVILRELIAS MAGVVPDTDF TDAQITAMTG GPALRRHTLI NLQDLRYESV KTAKRLIRAL
TESKLAGQLL LSIAQHKQSA IYTISDEEAH IKMLATMVDE AQSMLFQYLD LLRSNLSVEE
FDEHVPRIPD LMTEFGLAPS LAFMIGRASL VHHILQLAPP VLNGDRKAIM SPPEAKTDTE
GDIGMNEPGD NAAIGDGTSA IVKSENDVEM ADKDGRSSGT PNPVQNGAGD SYDKLMEPLV
SCVQTVLSEH TWNAMSPDFY VTFWSSTLSD LNPPDLLYDA EIKKIREQER IVGNDRADMS
RSGLAKKEET KKKLAETRED ILAEMHKEVD AFTKGRTRLL KRKSQWLQTS VKILPDRVSD
ELLEKCFIPR LLLSPTDADY SFRMIKFLHD NAVPNFRTLS VYLRIFRTNR LRTIIFTCSV
REAENLGRFL KSALLDLQKW HSDNAIYDEQ AFGRRKSLIG FAKKLEADGT PVAFLPYEDF
QSLLLRLHTA LYSSLHDCFD GTEWMQIRNA ITILKTVAEV FPTVDTQGLD LIAQLEALTA
REKNVREDLA LTGNAVLVLL KRRTKNWISQ KKFAPLAPLP KVTNGGAAPS SANSKASTPK
TSLKPTAPEF QPKSRASSAG VSTPKPGEVE DGEVDDARHA KNATAAAKNL SDAQPAAPST
PANPPPQRSE ILIQREKVKA ERAAQALANV PSRPETSRPH TPSTILDRAP PSLPNRPDAP
IPAHSHIDRH RHSERRDERS PRVVDSARVD RPGDRTREYP AGNRRTAEPN PREFGRSTDR
GLIPDRERSR PEPPPRWVPD SSRENTERGL NGSRSNDNIG RLSREHAMAP PRSTAPLIDR
GVVVNSDRLS QINSESKDLI DPGRAALISS SDARSDSPRR HRDDVRDRPS PRNQSPRRHP
SDRDHTDSRR DDRSTRGGPA DVNTPPRARH DDPGVAPIGP RGDRSVERAP ERNDRASFPS
TPPVARPIDP DHGRLNAGNR QPPPDPNFGR LNPSSAQDIP SGPRDRQIRG ANRASGTHAP
RGDGRPSMDQ QIPRPPTPDK QPPTGPSSGR HPRRSTSGQF DNASHQGGMP QNTPPAGGSA
PGVHPDRLKH LPHTPNQPHI SHQQHTPHQH QPPIQPPLPM SAPIHPDRLK KLGSDGPNVP
LPTVSQMNNN RQRPPVPSLN TSGPPSGPKG SQLSPVNPNP NGMAPPTGPA SAQERAQRGG
RRQLAGINNM LQQGGTQNGS ISVRGRGRVS AGLQQESPIS TSPNQIPPPP PGPPPGRQAP
REISRDMVNP ARADLIEGSM DEREKDRSSR RSGRHSRRSS KSPGRERDSK RGNPEEDRPP
RGDYRERRGG DRENDRERHP GRSPTRDLMA GRDGSSGAPR EGHRDRDSSR RDGRERDTAR
EPHDGQWPGE RGPERAPGGR GREPRGDGRG SDDRRSGEGR DNRPSRGDES RKRRSDEGAI
DPRGHDKRPR RM
//
