ID S3D159_GLAL2 Unreviewed; 2595 AA.
AC S3D159;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=GTPase activation, GAP {ECO:0000313|EMBL:EPE25751.1};
GN ORFNames=GLAREA_01663 {ECO:0000313|EMBL:EPE25751.1};
OS Glarea lozoyensis (strain ATCC 20868 / MF5171).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Helotiales; Helotiaceae; Glarea.
OX NCBI_TaxID=1116229 {ECO:0000313|EMBL:EPE25751.1, ECO:0000313|Proteomes:UP000016922};
RN [1] {ECO:0000313|EMBL:EPE25751.1, ECO:0000313|Proteomes:UP000016922}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 20868 / MF5171 {ECO:0000313|Proteomes:UP000016922};
RX PubMed=23688303; DOI=10.1186/1471-2164-14-339;
RA Chen L., Yue Q., Zhang X., Xiang M., Wang C., Li S., Che Y.,
RA Ortiz-Lopez F.J., Bills G.F., Liu X., An Z.;
RT "Genomics-driven discovery of the pneumocandin biosynthetic gene cluster in
RT the fungus Glarea lozoyensis.";
RL BMC Genomics 14:339-339(2013).
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DR EMBL; KE145371; EPE25751.1; -; Genomic_DNA.
DR RefSeq; XP_008087070.1; XM_008088879.1.
DR STRING; 1116229.S3D159; -.
DR GeneID; 19460721; -.
DR KEGG; glz:GLAREA_01663; -.
DR eggNOG; KOG1826; Eukaryota.
DR HOGENOM; CLU_000249_0_2_1; -.
DR OMA; TKEPYMF; -.
DR OrthoDB; 1356198at2759; -.
DR Proteomes; UP000016922; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProt.
DR CDD; cd05392; RasGAP_Neurofibromin_like; 1.
DR Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR10194:SF150; INHIBITORY REGULATOR PROTEIN IRA1-RELATED; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00616; RasGAP; 1.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000016922}.
FT DOMAIN 1232..1425
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT REGION 105..148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2595 AA; 289512 MW; 526874A0E886C26A CRC64;
MNGDSSLVVT LVDRLTTRLP HRTGSPSHEF ARDEVVVLTR STLVGVSNAC IAVVIEALVQ
LLEELARPYK GLHSHPIHVV YSELYVLALL ADCCSKHWDT VNAGSRSLTS ENGTSDSEDT
DAGRILKNSP GAKGLQNKRR ASRNTLLART QPPDALSDDL VRRLFDAVKL FSRPVPDTYI
LPSSNILDDS HKKFDKYDIF RQDPVDSFDG QLSGTEVPKL LLENTDAIDA FTRVIVEYLS
FSNWTKVLEY LRIALVQAVH PALTGPGLPN VLVDDDRSAL IVIRYISCFW VDARKLGVLI
QELCGNFLHL RKTFQTTVAV VVPQLITRWL ERNPQEFVDL HSTHKRLDGG ADTLFDMTTT
TFDGGRRKAL LFPFQISLLL LLPEVFEVAS NMRDAKSSGI TKKVSFLEML RKALKNRNET
AVYCLTSVLR VARHFSLDSD AAILSYALDV QEEVREAVFR NPSTGIDTSN IDGPLMTATF
VSLTHLNFEH SVASLARLCL APNAAQSFKL AVISACSHFA RQSNPEDYQP LYAKVADFIR
AQIKSQALKM RESHSDEPYP ILKPLEVATS SDMIYNILLF LDASPLTLLV GAPDNTDDWV
KFFESTLTSF LIYLVTDDER TRHMTCTVAR KLMTEGTTAI YHRVETPETK LFKHTFWRTS
SVVLMTVAER LINMTDDGKV TLHFVHDFLE ARLLLLKHIK ELRDLEEDIP ERVAACSKLE
TAFLVSLCST DISACQLVTK CISLFCDEGR IVDGSTASSA KALTPTLRNL DLYTEISSRD
FRFTGLVAFQ KRVRGLLRQM AHPTAGMLAA WETVFDFWLR ISKHIFSRPA EILEERALVE
WRNYSGFLAS LGGTCISGRT PSPEESNFAG LRWIDRLLPD SYDENLLTKY MRQSVQLLAS
NNVRIREATR ETLSTELASP LYLPLFENLE TELGTLFDSP RTNTSLSVES RIIFAEQASA
LLRSIVEKLG GPAEVGTSLS VDVGALTLNF AKFLDEIQEG ASVLRVKIKI CQLCETVTQK
KELLNLRHDV RIRNQLLEVI FSWIARPGTP NDAIHAPGAR AEELLRLQKD LDKACLKALA
DLTYRLPLQP ADGQSDADTS DLKSQMFHTY FNRFLSLLNY DSGDARRNDA RSLPVGNDDS
SNTSELAITA LSNLLSANID VGLKHSLGIG YHEDLDIRTA FVKVLCNILI QGAEFNNLSD
TAVNEKYDEL LELLINDMPL TIALCDACPS NEVDEMTISL LNIFDSRGLG SVLLEGLIDH
EVEQTENEAE LLRRNCVATK MLSLYAKWKG ASYLKATLQE VLERLVLTSK DLDLELDPAR
VTSAEELNKN ALQLKVVTRV FIEDICSSAP HMPVSFRKIC SIISTAVMKR FPDAIFTAVG
AFIFLRFFCP AIVAPDVEGL ISSPLSKEMR RGLLLIAKVV QNLANNVLFG AKEPFMYPLN
QFLTQHIYRV TTFLREISVA PNVNEPTVDS EAFDFGSCVA LHRFLYDHWD HVRQKIVLRE
RKGVVVSPLV EIGSSVPMLE SLRKLITNLG PPPMDVSWNR PMISQNTPPS YSRFQHFMLK
NAGRNTESLV STRAVYDGGE SKDGLPMICI ILRNIDTETV DWELLLFGYL KIASRMWHRP
FGILIDATCY NGQNEPQDAL FKQLDLLTPT ELSRQLSRVF VYNMNSAFRK CFRRILRLAA
KSENSAFHPK NVDYHLIGSL QDLQAHFHLS QLHLPKDTIS VVTDTRYVFQ PITRLSKTKG
KVEVVIKVGS QFVQVTTAKK QEVVPGLRLH ATVNDIFRLS EVDEAPTSIQ TEDDSAFGLR
TENGKIVMYF TSPRKPEVLQ AVRGAKSKQG KELRTLKSFE RLVRPQDVPG TLLNIALTNM
ASSDQVLRLA SYNLLCALCR AFKFAADAKF MSTKELCVPL NPSNFIIDIS KQLALSEPQL
TVDFLNEFFV GWESFPYSQR PLSLAYMAPW LPGLRTTSIP NDTDSDKARE KIAVIFRKLI
EVAISDVTLS TTFEHRIWPM ICCEETYTDI FLEEVTKIAL SYGIDDERTE ILGSVIASLG
TITIRGKLLS RLRKALNRTS LRPTRHLPDN TVWSEICVLL RLCLSTSFDS GVQSQLFLPE
LFHLVTMLAN TGSPEVRVMV HRLLTNTIHA MCTTFSLEEV KMARLKVLLL SISEPGNDSL
FNVAAREGAS ISFLQDSGMP ALNATESLAI LLSEVSTVAA PTIDTSNAWR SRWMSLVAST
AFQSNPAIQP RAFTVMGCLA REDVDDDLLY QVLVALRSSV GRFMEDGDSE MLVAIVTSLT
KMMDKLPSAS RYGLQLFWLA LSLIRLVPLP LFNCTASFLD AVLNNIATSG EFKDGRMVPV
LLQGRLPLDD AAFQLDEIYG VHFSIESFHF AVVACLVKGL SDSVTKATAV RVLSTFLETT
SANTADGTKF PADLSYVPYL GALMSRAMTP SEAQQSWAAN KTIMGGDLTT GEVTNVIDLT
IIKDKELLLN VAIGIVDFRY LEEAIQNRGL LWLNKVALKR PTVVLHLCAP IISILDDVLL
NCQNAATLES AHKLLRTITS NPKFAGGVDT AEMLEDVLDG IGFGGLWRSA TFHTQNEHER
ECTALTDRLI ELIIA
//
