ID S3D173_OPHP1 Unreviewed; 453 AA.
AC S3D173;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=3-hydroxyisobutyrate mitochondrial {ECO:0000313|EMBL:EPE07025.1};
GN ORFNames=F503_03452 {ECO:0000313|EMBL:EPE07025.1};
OS Ophiostoma piceae (strain UAMH 11346) (Sap stain fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Ophiostomatales; Ophiostomataceae; Ophiostoma.
OX NCBI_TaxID=1262450 {ECO:0000313|EMBL:EPE07025.1, ECO:0000313|Proteomes:UP000016923};
RN [1] {ECO:0000313|EMBL:EPE07025.1, ECO:0000313|Proteomes:UP000016923}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UAMH 11346 {ECO:0000313|EMBL:EPE07025.1,
RC ECO:0000313|Proteomes:UP000016923};
RX PubMed=23725015; DOI=10.1186/1471-2164-14-373;
RA Haridas S., Wang Y., Lim L., Massoumi Alamouti S., Jackman S., Docking R.,
RA Robertson G., Birol I., Bohlmann J., Breuil C.;
RT "The genome and transcriptome of the pine saprophyte Ophiostoma piceae, and
RT a comparison with the bark beetle-associated pine pathogen Grosmannia
RT clavigera.";
RL BMC Genomics 14:373-373(2013).
CC -!- SIMILARITY: Belongs to the HIBADH-related family.
CC {ECO:0000256|ARBA:ARBA00009080}.
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DR EMBL; KE148152; EPE07025.1; -; Genomic_DNA.
DR AlphaFoldDB; S3D173; -.
DR STRING; 1262450.S3D173; -.
DR VEuPathDB; FungiDB:F503_03452; -.
DR eggNOG; KOG0409; Eukaryota.
DR HOGENOM; CLU_035117_1_2_1; -.
DR OMA; QMFMQAS; -.
DR OrthoDB; 1121581at2759; -.
DR Proteomes; UP000016923; Unassembled WGS sequence.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002204; 3-OH-isobutyrate_DH-rel_CS.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR029154; HIBADH-like_NADP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43060; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR PANTHER; PTHR43060:SF15; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF14833; NAD_binding_11; 2.
DR Pfam; PF03446; NAD_binding_2; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00895; 3_HYDROXYISOBUT_DH; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000016923}.
FT DOMAIN 5..168
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 181..302
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
FT DOMAIN 321..440
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
SQ SEQUENCE 453 AA; 46681 MW; 140C63037399966C CRC64;
MSKPDISFIG LGAMGFGMAT NLVKRGYAVT GFDVWAPTLD KFAAAGGKTA TTPAAASVDK
PVCVCMVATA QQAQAVLIDG PDAAAAALPQ GSAILLCSTV PCGYVQDLAR QIADPNGPVK
RPDLLLVDCP VSGGAARAAD GTLSIMAGSP DAAFNAHAHA KSVLADLADP EKLYLIAGGI
GAGSNTKMVH QVLAANQILS GCEGMGLAVR LGLEANETTL NTLLASPGHS WMFGHRGPRM
INNFQPIASA VQIIVKDTAI ITSEARRMGF IVPMTSAVEN VMYDAMARGY ALDDDSSILR
VYTNGRENVP PAPASLTADD KIKLVIDLLK GIHLASAAEC LAFAHHVNLD LDMVLGLCIN
AAGGSAMLEA HGPHIIAALR NGTAASGWAP AEGEETLESI YKGLEAAVVI AQQIKAPLYL
GTQALTVLRM ALRSSGPKAS SIAAGSVVKV WLE
//
