ID S3D1H7_GLAL2 Unreviewed; 333 AA.
AC S3D1H7;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=NAD(P)-binding Rossmann-fold containing protein {ECO:0000313|EMBL:EPE31019.1};
GN ORFNames=GLAREA_03986 {ECO:0000313|EMBL:EPE31019.1};
OS Glarea lozoyensis (strain ATCC 20868 / MF5171).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Helotiales; Helotiaceae; Glarea.
OX NCBI_TaxID=1116229 {ECO:0000313|EMBL:EPE31019.1, ECO:0000313|Proteomes:UP000016922};
RN [1] {ECO:0000313|EMBL:EPE31019.1, ECO:0000313|Proteomes:UP000016922}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 20868 / MF5171 {ECO:0000313|Proteomes:UP000016922};
RX PubMed=23688303; DOI=10.1186/1471-2164-14-339;
RA Chen L., Yue Q., Zhang X., Xiang M., Wang C., Li S., Che Y.,
RA Ortiz-Lopez F.J., Bills G.F., Liu X., An Z.;
RT "Genomics-driven discovery of the pneumocandin biosynthetic gene cluster in
RT the fungus Glarea lozoyensis.";
RL BMC Genomics 14:339-339(2013).
CC -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC family. Dihydroflavonol-4-reductase subfamily.
CC {ECO:0000256|ARBA:ARBA00023445}.
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DR EMBL; KE145363; EPE31019.1; -; Genomic_DNA.
DR RefSeq; XP_008082430.1; XM_008084239.1.
DR AlphaFoldDB; S3D1H7; -.
DR STRING; 1116229.S3D1H7; -.
DR GeneID; 19463041; -.
DR KEGG; glz:GLAREA_03986; -.
DR eggNOG; KOG1502; Eukaryota.
DR HOGENOM; CLU_007383_9_2_1; -.
DR OMA; CDAVVCM; -.
DR OrthoDB; 552946at2759; -.
DR Proteomes; UP000016922; Unassembled WGS sequence.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR001509; Epimerase_deHydtase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR10366:SF562; ALDEHYDE REDUCTASE II (AFU_ORTHOLOGUE AFUA_1G11360); 1.
DR PANTHER; PTHR10366; NAD DEPENDENT EPIMERASE/DEHYDRATASE; 1.
DR Pfam; PF01370; Epimerase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000016922}.
FT DOMAIN 11..254
FT /note="NAD-dependent epimerase/dehydratase"
FT /evidence="ECO:0000259|Pfam:PF01370"
SQ SEQUENCE 333 AA; 36524 MW; 1A1E4B2066FBD340 CRC64;
MTSAIAKDSI VLVTGCNGFI GSHVVDQSLQ AGYRVRGTTR DLKKLERLTK LWEEKHGAGR
FEAVVVPNMA EDGAFDDAVK GVSAIAHVAS NLTFKADPNA VIPEVIAGIK SILKSAASSA
TVKRFVFTSS STAAASPIPN KVFHIDSKTW NDAVVDEAWA PPPYEPMRAY AVYSASKVEA
ERALWKFVEE NKPGFVVNAV LPDTVFGKIL DRNLHVSTAG FVNALYKGEQ QHLPPQWFVD
VQDVALLHLA CMTDPLIKNE RIIAFAEPWN WNDILRIMRK LRPNEKIIDD YADDNARDLS
TVDNARGNEI LKGFGKSGFT SLEESVKGNI DGL
//
