ID S3D247_GLAL2 Unreviewed; 976 AA.
AC S3D247;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=Ras GEF {ECO:0000313|EMBL:EPE32617.1};
GN ORFNames=GLAREA_07751 {ECO:0000313|EMBL:EPE32617.1};
OS Glarea lozoyensis (strain ATCC 20868 / MF5171).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Helotiales; Helotiaceae; Glarea.
OX NCBI_TaxID=1116229 {ECO:0000313|EMBL:EPE32617.1, ECO:0000313|Proteomes:UP000016922};
RN [1] {ECO:0000313|EMBL:EPE32617.1, ECO:0000313|Proteomes:UP000016922}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 20868 / MF5171 {ECO:0000313|Proteomes:UP000016922};
RX PubMed=23688303; DOI=10.1186/1471-2164-14-339;
RA Chen L., Yue Q., Zhang X., Xiang M., Wang C., Li S., Che Y.,
RA Ortiz-Lopez F.J., Bills G.F., Liu X., An Z.;
RT "Genomics-driven discovery of the pneumocandin biosynthetic gene cluster in
RT the fungus Glarea lozoyensis.";
RL BMC Genomics 14:339-339(2013).
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DR EMBL; KE145359; EPE32617.1; -; Genomic_DNA.
DR RefSeq; XP_008080629.1; XM_008082438.1.
DR AlphaFoldDB; S3D247; -.
DR STRING; 1116229.S3D247; -.
DR GeneID; 19466803; -.
DR KEGG; glz:GLAREA_07751; -.
DR eggNOG; KOG2378; Eukaryota.
DR HOGENOM; CLU_005431_1_0_1; -.
DR OMA; HIAKWVA; -.
DR OrthoDB; 4819765at2759; -.
DR Proteomes; UP000016922; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00882; Ras_like_GTPase; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR001806; Small_GTPase.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF348; GUANYL-NUCLEOTIDE EXCHANGE FACTOR RASGEF, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04700)-RELATED; 1.
DR Pfam; PF00071; Ras; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000016922}.
FT DOMAIN 476..602
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 722..960
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 1..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 93..141
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 335..444
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 614..636
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..46
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 107..121
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 122..141
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 343..359
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 409..430
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 976 AA; 108722 MW; 374D01088EAE2B9C CRC64;
MEELKTGTLR NKSSRAWPAN SSRDPNRGNR SPKILTASSP RSPRPGASPR TASAPLVPLS
RDLAPQIAND DLYKHRGSIA SIQDDPFFKH YQTPQSVTLS KEMRSATQWP RRGEEDSEAQ
SPRSATRTAP DNSVNLPPQS RSGMSDINIA IIGSGGCGKS TLIQRALGLR SLPASSASSA
RMSVDNVEYT VSLIELDLES FDIARDRRIE WPKQINGHIV PRMDGALLLY DVMNRESIAA
LPPTLNGLVN SALPTILVSC KCDNPENTRQ VDVESMENAC HSCIEAVKTA ANVPESARLC
LSSMLRAIMA KRNAANYAPE KDVSGARRRA ISSAHLETPA ADPTSRPLSQ QSKHSRASSD
YSLLRGLPSP PHVSSRAKPP STRHNGRTNL HHQFKLPDPQ EAPPLSSHPA FRQDNTQSGD
SDSKLLPNAS RSPLPSPGKI MDSSYIDMEG SESESSYRYS DDTPILHRND DSFFDKPAKV
AGVTFDELVD RLLGQNMSRA DNNFSDIFLC LYRKFAAPGE LFAAILGRLD AIAADKNTHY
LTRTAIQLRI ITVVARWVSS YPGDFASPST SRNLDAFINH LSSEPVFAAA AQDMRMQLQS
RVVEDDDTGW ARTDADVETE SGSLAESAPS SPLKRRNPIA DLERHVQQLG VSQEGDEDEG
YEIEQLHKSE STTYSNRPSS HNPSLSSSFN TVEDYEKEAA TMVPRGQIPL TKFRYRIFMD
TSEDDIADEM TRIDWVMFSS IRLRDFVRHV SLPLELKEKC KSLTNVNRMI NHFNHIAHWV
ANMILIRDKA KHRAVMLEKF MTIALKLRQL NNYNGLAAVL AGIGGSAIHR LTQTRTLVPA
DVQKRFARLV LLMGSQKSHF AYRLAWENSP LPRIPFIPLH RRDLVSAEEG SRTFVGQNGE
RINWKKFEVL SEVILPIMKS QVMPYPNLSR HEGAREMILD CLMPVDDEEI YQRSLEVESS
SGPVEMAKKK FPWFQK
//
