ID S3D357_OPHP1 Unreviewed; 330 AA.
AC S3D357;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Enoyl reductase tsc13 {ECO:0000313|EMBL:EPE07715.1};
GN ORFNames=F503_00437 {ECO:0000313|EMBL:EPE07715.1};
OS Ophiostoma piceae (strain UAMH 11346) (Sap stain fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Ophiostomatales; Ophiostomataceae; Ophiostoma.
OX NCBI_TaxID=1262450 {ECO:0000313|EMBL:EPE07715.1, ECO:0000313|Proteomes:UP000016923};
RN [1] {ECO:0000313|EMBL:EPE07715.1, ECO:0000313|Proteomes:UP000016923}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UAMH 11346 {ECO:0000313|EMBL:EPE07715.1,
RC ECO:0000313|Proteomes:UP000016923};
RX PubMed=23725015; DOI=10.1186/1471-2164-14-373;
RA Haridas S., Wang Y., Lim L., Massoumi Alamouti S., Jackman S., Docking R.,
RA Robertson G., Birol I., Bohlmann J., Breuil C.;
RT "The genome and transcriptome of the pine saprophyte Ophiostoma piceae, and
RT a comparison with the bark beetle-associated pine pathogen Grosmannia
RT clavigera.";
RL BMC Genomics 14:373-373(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the steroid 5-alpha reductase family.
CC {ECO:0000256|ARBA:ARBA00007742}.
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DR EMBL; KE148150; EPE07715.1; -; Genomic_DNA.
DR AlphaFoldDB; S3D357; -.
DR STRING; 1262450.S3D357; -.
DR VEuPathDB; FungiDB:F503_00437; -.
DR eggNOG; KOG1639; Eukaryota.
DR HOGENOM; CLU_059260_0_1_1; -.
DR OMA; WAWKKEK; -.
DR OrthoDB; 1202332at2759; -.
DR Proteomes; UP000016923; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016627; F:oxidoreductase activity, acting on the CH-CH group of donors; IEA:InterPro.
DR GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR Gene3D; 1.20.120.1630; -; 1.
DR InterPro; IPR001104; 3-oxo-5_a-steroid_4-DH_C.
DR InterPro; IPR039357; SRD5A/TECR.
DR PANTHER; PTHR10556; 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE; 1.
DR PANTHER; PTHR10556:SF28; VERY-LONG-CHAIN ENOYL-COA REDUCTASE; 1.
DR Pfam; PF02544; Steroid_dh; 1.
DR PROSITE; PS50244; S5A_REDUCTASE; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000016923};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 273..298
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 224..304
FT /note="Steroid 5-alpha reductase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50244"
SQ SEQUENCE 330 AA; 37438 MW; 46257BB24B168B64 CRC64;
MAPLQLKVAN RGKSRSVKNL PPTIDVSTAT TIEEVQQLVA KQSGVRDYNR IGIFDPVSRK
IIRDRRAVLG AQDDVLKTKE ILVQDLGAQI GWRTVFVIEY AGPILFHLAF YYLRPIIPLP
AFLVGTQAAS RQDPLTDIQK LVHTLFVAHF VKRELETIYL HRFSANTMPA FNIFRNSAFY
WLLAGLFDSW SVYAPLSPFR LSSEFPRATP ARSGFGTSVL DYIGLAMFIF CELANFSVHY
HLANLRKPGS TEKGIPNCIG SSLVTSPNYM FEVLAWVGVI ILSRDLSVLI FISIGVIYMR
SWSRDKERAL RRLFPDRYKK KKYTMLPGLI
//
