ID S3D4M0_GLAL2 Unreviewed; 585 AA.
AC S3D4M0;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Xanthine/uracil permease {ECO:0008006|Google:ProtNLM};
GN ORFNames=GLAREA_07869 {ECO:0000313|EMBL:EPE32735.1};
OS Glarea lozoyensis (strain ATCC 20868 / MF5171).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Helotiales; Helotiaceae; Glarea.
OX NCBI_TaxID=1116229 {ECO:0000313|EMBL:EPE32735.1, ECO:0000313|Proteomes:UP000016922};
RN [1] {ECO:0000313|EMBL:EPE32735.1, ECO:0000313|Proteomes:UP000016922}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 20868 / MF5171 {ECO:0000313|Proteomes:UP000016922};
RX PubMed=23688303; DOI=10.1186/1471-2164-14-339;
RA Chen L., Yue Q., Zhang X., Xiang M., Wang C., Li S., Che Y.,
RA Ortiz-Lopez F.J., Bills G.F., Liu X., An Z.;
RT "Genomics-driven discovery of the pneumocandin biosynthetic gene cluster in
RT the fungus Glarea lozoyensis.";
RL BMC Genomics 14:339-339(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC
CC 2.A.40) family. Azg-like subfamily. {ECO:0000256|ARBA:ARBA00005697}.
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DR EMBL; KE145359; EPE32735.1; -; Genomic_DNA.
DR RefSeq; XP_008080747.1; XM_008082556.1.
DR AlphaFoldDB; S3D4M0; -.
DR GeneID; 19466921; -.
DR KEGG; glz:GLAREA_07869; -.
DR eggNOG; ENOG502QQ5E; Eukaryota.
DR HOGENOM; CLU_024508_3_2_1; -.
DR OMA; AYCTDAF; -.
DR OrthoDB; 35157at2759; -.
DR Proteomes; UP000016922; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015205; F:nucleobase transmembrane transporter activity; IEA:InterPro.
DR GO; GO:1904823; P:purine nucleobase transmembrane transport; IEA:UniProt.
DR InterPro; IPR045018; Azg-like.
DR InterPro; IPR006043; NCS2.
DR PANTHER; PTHR43337:SF3; PURINE TRANSPORTER; 1.
DR PANTHER; PTHR43337; XANTHINE/URACIL PERMEASE C887.17-RELATED; 1.
DR Pfam; PF00860; Xan_ur_permease; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000016922};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 91..119
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 139..163
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 175..200
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 234..251
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 258..279
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 319..339
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 360..384
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 468..487
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 585 AA; 63167 MW; 16E5F3385CA07A3D CRC64;
MVTIRERIKV YDVRIATSTF GRVFRLDGSG HEFERPGSTF FTEINAGLTT FFTMAYIIAV
NSSILSDSGG TCVHQNEAQY KDCLLDIKRD LITATAAVAG IGSILFGFLT NLPVAIAPGM
GLNAYFTYQV VGYHGSGSVS YQLALTAVFI EGFIFVFLSL IGMRQWLVRI IPGSIRVASG
VGIGLFLTEI GLSASGISMI SSGAAAPTDL AGCPPQYMDP KNGSCLSHKM TSPTMWIGIM
CGGMLTSWLM AYRVKSAIII GITVVSILSW PRNTSFTYFP NTPLGDEMHN FFIKVVSFHP
IQNTLGALDW DVSAAGGHFV LALFTFLYVD IIDTTTTLYS MARFSGVTDP KTGDFPRSTM
AYCTDATMIS ISALFGCSPT TAFIESGAGI TDGGRTGLTA MTTGVCFLIS IFFAPIFASI
PPWATGGTLI LVGCMMMRQV TAVNWSFIGD ALPAFVTIVC MPLTYSVAYG LIAGLFTYTV
LNGLFFITRK ISRERIQPPD ADIAEYWTYK PSDEHPPWFI RAAKGELWRS RESVEEIEVR
SLASRTSEKV LVDGSGRVVP GLSAETEDGV QRSDSFRAGS AAVAV
//
