ID   S3D536_OPHP1            Unreviewed;       990 AA.
AC   S3D536;
DT   18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT   18-SEP-2013, sequence version 1.
DT   27-MAR-2024, entry version 36.
DE   SubName: Full=Dna damage response protein {ECO:0000313|EMBL:EPE08525.1};
GN   ORFNames=F503_04112 {ECO:0000313|EMBL:EPE08525.1};
OS   Ophiostoma piceae (strain UAMH 11346) (Sap stain fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Ophiostomatales; Ophiostomataceae; Ophiostoma.
OX   NCBI_TaxID=1262450 {ECO:0000313|EMBL:EPE08525.1, ECO:0000313|Proteomes:UP000016923};
RN   [1] {ECO:0000313|EMBL:EPE08525.1, ECO:0000313|Proteomes:UP000016923}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UAMH 11346 {ECO:0000313|EMBL:EPE08525.1,
RC   ECO:0000313|Proteomes:UP000016923};
RX   PubMed=23725015; DOI=10.1186/1471-2164-14-373;
RA   Haridas S., Wang Y., Lim L., Massoumi Alamouti S., Jackman S., Docking R.,
RA   Robertson G., Birol I., Bohlmann J., Breuil C.;
RT   "The genome and transcriptome of the pine saprophyte Ophiostoma piceae, and
RT   a comparison with the bark beetle-associated pine pathogen Grosmannia
RT   clavigera.";
RL   BMC Genomics 14:373-373(2013).
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DR   EMBL; KE148148; EPE08525.1; -; Genomic_DNA.
DR   AlphaFoldDB; S3D536; -.
DR   STRING; 1262450.S3D536; -.
DR   VEuPathDB; FungiDB:F503_04112; -.
DR   eggNOG; ENOG502QQ7Y; Eukaryota.
DR   HOGENOM; CLU_007951_0_0_1; -.
DR   OMA; FRITWHP; -.
DR   OrthoDB; 1973610at2759; -.
DR   Proteomes; UP000016923; Unassembled WGS sequence.
DR   GO; GO:0030870; C:Mre11 complex; IEA:InterPro.
DR   GO; GO:0006302; P:double-strand break repair; IEA:InterPro.
DR   GO; GO:0007095; P:mitotic G2 DNA damage checkpoint signaling; IEA:InterPro.
DR   Gene3D; 2.60.200.20; -; 1.
DR   Gene3D; 3.40.50.10190; BRCT domain; 1.
DR   Gene3D; 3.40.50.10980; Nibrin, BRCT2 domain; 1.
DR   InterPro; IPR036420; BRCT_dom_sf.
DR   InterPro; IPR000253; FHA_dom.
DR   InterPro; IPR040227; Nibrin-rel.
DR   InterPro; IPR032429; Nibrin_BRCT2.
DR   InterPro; IPR043014; Nibrin_BRCT2_sf.
DR   InterPro; IPR008984; SMAD_FHA_dom_sf.
DR   PANTHER; PTHR12162:SF0; NIBRIN; 1.
DR   PANTHER; PTHR12162; NIBRIN-RELATED; 1.
DR   Pfam; PF00498; FHA; 1.
DR   Pfam; PF16508; NIBRIN_BRCT_II; 1.
DR   SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR   PROSITE; PS50006; FHA_DOMAIN; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000016923}.
FT   DOMAIN          5..67
FT                   /note="FHA"
FT                   /evidence="ECO:0000259|PROSITE:PS50006"
FT   REGION          183..212
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          386..485
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          507..576
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          682..990
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        393..410
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        463..477
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        528..576
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        685..701
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        724..746
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        758..802
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        815..832
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        844..858
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        870..931
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        976..990
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   990 AA;  107189 MW;  2A54B93037352122 CRC64;
     MWLLENAGNA FQAGQLVISD KTISRKHLTI EVDRVRDGDG RDPGSRSVVT IEDLATKIGT
     VVNGTQIRGQ KFVLIQDTND LKMGHMPDLF RITWHPIVFS FSFSSKELRA LPDPWQQLKK
     DLEPLDIKYI PEFDRARTTH VVAKKRNTSK GLQALINGDY IVTEAYIAAI VAAASSGEPS
     LESDFSKAWP SPLDHLPPRG DEPSDRPVST YSPDTRRANI FEGYTFVFYD QKQFDTLLPP
     IAEGRGKALL GTVVPGQTEV DDFVRYVKGV AGEKGLGEFE DGSEGRGVVV VRHVPAKGDH
     VEWFTRFTTA VALRLDHRLI DQREFLDAVL AVEPSMLRRP LEVDVAGDQP PPRRTLTFAS
     ASASASIPAG GMDVDDHILP SVDAEEELVQ RPPPLSQSLS QASSTRRARA RRGGTASRFK
     GFDVDLDSGD EDGTGVGTGA VPVKQRNDEK DGMFMSQTPA VEEQARRNKR HPPDDEDMDD
     ADGLTNVMDD IAPTAALVKR RRIEAGIDPV PARESPFQED GEDDDDNEAE KDKKAKLKKG
     VGKTAVKKEK LEGSDDILGQ ARRNREAADE KRRLDEERER LAAADIPDDG IDAEAIRKLT
     LVETIQVREA GSATRTREQD IADGRWDPQW NGRRNFKKFR KQGDIVGRVP QRVIIGLEPA
     KTKEYGIGDD YWLEGGDDER AWRGSGSHNT NGSSGRTGRN EVPPNTRGGL APSRRSGTPS
     GRVIDADDMD DTSIAGHDDA EPSESGDVPA SRRAAAASTP SIPATNSTGS VRRPAPSTLA
     SGSIPILASG LGSGSGSHGG ESLGSGMVNL EIIPDTDPED EHHGRGHEVA SDDDDDDNNS
     LSVGTKDTRD SLAVSQLSDL PRTRAGKVAS RPARQNQNQS QTAAPHPPAA ATRTTRTTRT
     SRRGALPPSG DTGSSLFDSV QAPSTQVSDL RATRAKRAAP APSARLQSPA KRPRRGAAAD
     TDSMAASSAP IAISDSDDDD GLRFKFKSRR
//