ID S3D5I1_GLAL2 Unreviewed; 747 AA.
AC S3D5I1;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=Origin recognition complex subunit 1 {ECO:0000256|RuleBase:RU365058};
GN ORFNames=GLAREA_07497 {ECO:0000313|EMBL:EPE32364.1};
OS Glarea lozoyensis (strain ATCC 20868 / MF5171).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Helotiales; Helotiaceae; Glarea.
OX NCBI_TaxID=1116229 {ECO:0000313|EMBL:EPE32364.1, ECO:0000313|Proteomes:UP000016922};
RN [1] {ECO:0000313|EMBL:EPE32364.1, ECO:0000313|Proteomes:UP000016922}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 20868 / MF5171 {ECO:0000313|Proteomes:UP000016922};
RX PubMed=23688303; DOI=10.1186/1471-2164-14-339;
RA Chen L., Yue Q., Zhang X., Xiang M., Wang C., Li S., Che Y.,
RA Ortiz-Lopez F.J., Bills G.F., Liu X., An Z.;
RT "Genomics-driven discovery of the pneumocandin biosynthetic gene cluster in
RT the fungus Glarea lozoyensis.";
RL BMC Genomics 14:339-339(2013).
CC -!- FUNCTION: Component of the origin recognition complex (ORC) that binds
CC origins of replication. DNA-binding is ATP-dependent, however specific
CC DNA sequences that define origins of replication have not been
CC identified so far. ORC is required to assemble the pre-replication
CC complex necessary to initiate DNA replication.
CC {ECO:0000256|RuleBase:RU365058}.
CC -!- SUBUNIT: ORC is composed of six subunits.
CC {ECO:0000256|RuleBase:RU365058}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU365058}.
CC -!- SIMILARITY: Belongs to the ORC1 family. {ECO:0000256|ARBA:ARBA00008398,
CC ECO:0000256|RuleBase:RU365058}.
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DR EMBL; KE145359; EPE32364.1; -; Genomic_DNA.
DR RefSeq; XP_008080376.1; XM_008082185.1.
DR AlphaFoldDB; S3D5I1; -.
DR STRING; 1116229.S3D5I1; -.
DR GeneID; 19466550; -.
DR KEGG; glz:GLAREA_07497; -.
DR eggNOG; KOG1514; Eukaryota.
DR HOGENOM; CLU_012774_1_1_1; -.
DR OMA; YEDHPWE; -.
DR OrthoDB; 118994at2759; -.
DR Proteomes; UP000016922; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003682; F:chromatin binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd00009; AAA; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 2.30.30.490; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041083; AAA_lid_10.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR001025; BAH_dom.
DR InterPro; IPR043151; BAH_sf.
DR InterPro; IPR048867; ORC1_wHTH.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10763; CELL DIVISION CONTROL PROTEIN 6-RELATED; 1.
DR PANTHER; PTHR10763:SF23; ORIGIN RECOGNITION COMPLEX SUBUNIT 1; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF17872; AAA_lid_10; 1.
DR Pfam; PF21312; ORC1_wHTH; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF82061; BAH domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51038; BAH; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|RuleBase:RU365058};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW ECO:0000256|RuleBase:RU365058};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU365058};
KW Hydrolase {ECO:0000313|EMBL:EPE32364.1};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU365058};
KW Nucleus {ECO:0000256|RuleBase:RU365058};
KW Reference proteome {ECO:0000313|Proteomes:UP000016922}.
FT DOMAIN 80..207
FT /note="BAH"
FT /evidence="ECO:0000259|PROSITE:PS51038"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 267..289
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 747 AA; 83545 MW; 932C3C23EB71F2E1 CRC64;
MPRKAGPQTP KQKQAQKSAL AKKVLDAALE NSDQEGEEEH SRWEWIYETT LKNGKISTTK
DRSKSQSEKK VGFVRRADGL ECRIGDCVML TAPGNNSDWV GMIKGFVGQD HDGDELAEFL
WFSNEKEIHN KVKKRTDFLP NELYITVGID ESPIEAIKCK AIILTEKAFN SRFPAKKISR
QDKEEYNRTF ICRRGCNTGT TTYTEELNWD EIEHRTDEDI EKLIQKLTSE TVSRKRGRKP
GFKVVKRKKE DYHSEEDEDF EDDIVKTPRK KQKHSAITTP RKPKTPTKLL TPSHKRIVVK
KPLEFTPLGT RILDADHVYS SPFQTARSRL HVASVPDTLP CREDEFASVY SHLEAAIYEG
TGSCIYISGT PGTGKTATVR EVVAQLNASV QAEELDDFIF VEINGMKVTD PHQSYSLLWE
ALKGDRVSPS HALDLLEREF NHPSPRRVPC VVLMDELDQL VTKNQSVMYN FFNWPGLRHS
KLIVLAVANT MDLPERTLSN KISSRLGLTR ITFPGYTHDQ LMKIIQSRLL GVPGDIVEPD
AIQFASRKVA AVSGDARRCL DICRRAVELA EAESQNIVPN TPSKSGKGEK ISRSAGRVTI
ATIKRAINEA TTSPLQLYLR GLPLAAKILL AALLVRTRRT GVAESVLGDV LDEARRMAKM
DTGGKTSEFL LKDDAQRTKT ASSTQVTKTA RVLGMGLSAV DLMEAGIIGL EARKADRTGK
IRLSIGDEDL KLAFKDDPEI KDLGFTV
//
