ID S3D5U2_GLAL2 Unreviewed; 3989 AA.
AC S3D5U2;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Acetyl-CoA synthetase-like protein {ECO:0000313|EMBL:EPE33802.1};
GN ORFNames=GLAREA_06815 {ECO:0000313|EMBL:EPE33802.1};
OS Glarea lozoyensis (strain ATCC 20868 / MF5171).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Helotiales; Helotiaceae; Glarea.
OX NCBI_TaxID=1116229 {ECO:0000313|EMBL:EPE33802.1, ECO:0000313|Proteomes:UP000016922};
RN [1] {ECO:0000313|EMBL:EPE33802.1, ECO:0000313|Proteomes:UP000016922}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 20868 / MF5171 {ECO:0000313|Proteomes:UP000016922};
RX PubMed=23688303; DOI=10.1186/1471-2164-14-339;
RA Chen L., Yue Q., Zhang X., Xiang M., Wang C., Li S., Che Y.,
RA Ortiz-Lopez F.J., Bills G.F., Liu X., An Z.;
RT "Genomics-driven discovery of the pneumocandin biosynthetic gene cluster in
RT the fungus Glarea lozoyensis.";
RL BMC Genomics 14:339-339(2013).
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DR EMBL; KE145357; EPE33802.1; -; Genomic_DNA.
DR RefSeq; XP_008078954.1; XM_008080763.1.
DR GeneID; 19465868; -.
DR KEGG; glz:GLAREA_06815; -.
DR eggNOG; KOG1178; Eukaryota.
DR eggNOG; KOG1202; Eukaryota.
DR HOGENOM; CLU_000022_37_4_1; -.
DR OMA; KQLWFAS; -.
DR OrthoDB; 5396558at2759; -.
DR Proteomes; UP000016922; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:0018130; P:heterocycle biosynthetic process; IEA:UniProt.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR GO; GO:0009403; P:toxin biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 1.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd19532; C_PKS-NRPS; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 3.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 1.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR013120; Far_NAD-bd.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR013217; Methyltransf_12.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF20; HYBRID PKS-NRPS SYNTHETASE APDA; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF00668; Condensation; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF08242; Methyltransf_12; 1.
DR Pfam; PF07993; NAD_binding_4; 1.
DR Pfam; PF21089; PKS_DH_N; 1.
DR Pfam; PF00550; PP-binding; 2.
DR Pfam; PF14765; PS-DH; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00826; PKS_DH; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 2.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000016922};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 6..445
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 2405..2484
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3563..3640
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 2497..2570
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2507..2523
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2524..2567
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3989 AA; 439096 MW; CF38C32D5A61FDF4 CRC64;
MAQNVNEAIA VIGSGCRFPG KAISPARLWE LLCQPRDLSQ RIPVDRFNPE GFYHPDGLHH
GSSNVRDSYL LSEDYQHFDA DFFSIKPIEA NAIDPQQRLL LETVYEATES AGLKIEDMQG
SSTAVYVGVM GGDYSDLILR DPDSIPTYFA TGTARSILSN RISYFFDWRG PSMTIDTACS
SSLVAVDQAV QTLREGRSRV AIAAGANLIL GPENYIAESK LKMLSPNGRS RMWDIDADGY
ARGDGFAAIV LKTLSSALED GDHIESIIRE TGVNQDGRTK GITMPSASAQ ADLMRETYRR
AGLDLSKRSD RPQFFEAHGT GTPAGDPIEA EAISRAFFPA DDKSSKQSDG HGVLYVGSVK
TIIGHTEGTA GLAGLIKVSL ALQHGLIPPN LHFNHLSPSV APFYNNLEIP IALKAWPVIP
YGCPRRASLN SFGFGGTNAH AILESYSPNS LMSLKGSIQA NPVFIPFNFS ASSESSLRAS
LKAYSGILKE NESVDLRDLS GTLAFKRNAF AVKASFSGLT TDSLCSKIDS TLKTEGSNIG
IRSVSKSPSI LAVFTGQGAQ WAGMGRELIL GSDAVLQSVE RLETYLTELP IPDRPSWSLK
KELLATAPAS RLSEASIAQP LCTALQIILV DLLRSAEVKF TAVVGHSSGE IGAAYACGHI
SAKHAMYIAY YRGFHSQLAT GPDGKRGAMM AVATSMEDAQ EMCDIPDFAG RLSVAASNSA
TSVTLSGDFD AVEEAKQIFD EEKKFARLLK VDKAYHSHHM LPCTEKYIES LRRCEINVGD
LDNMNGSWFS SVYGGEFPAS PDSLADVYWN TNMLNPVLFS QAIGCAASTK GPFDVVLEVG
PHPALQGPVL EVIQQEIGKT IPYCGVLSRG KNDIETLSDA LGLIWSHLGA SAVNFQQYDS
LMSGGASFEF QEDLPLYAWD HERRFWYESR VSENYRTRQD SCHELLGVRV ADGTEQEIRW
RNMLSVKEVP WLRGHQIQGE IVFPAAGYVT MALEASLSLA GERSVVAIEV QDLVIGRPIS
FADEESGVET LFTLTNVSNA DGSATMCTAN FTCYSSPQNH KRGSTMILTA TGHLQISLGD
GHSNLLSSRP IEPLNLVEVD TSRFYSALSD LGYGYSGPFK GLSTLKRKMD VGTGLVASTN
STNTAKPMLI HPAMLDSAFQ AIFLGYGWPG DGRLWSMHVP TKIEKVKVNV SLCRSELRGD
VQLPFDCILS DNPLYPIYGD IDIFTRDGRS SIVQIEGVTA VPLSAASRAD DRNIFSDISW
NVALPNGLIA AENDRAKAED FELALLCERV AHLYLMELDK TFPPEVRASL QWNFQRLLDF
ASYTVRLVAA GRHPFAKKEW THDTREQVIP HARSFTDSTD LKLMLAVGDN LPAAIRGETE
ILEHMTRGNI LDDYYVSALG LPQCTRYIAK MASQFVNRYS NPKILEIGAG TGGATKSILK
YLKEQNQTVA SYTFTDISGG YFEKAREVFK DLSGNMLFSV LDVEKDVVSQ GYSEHSYDLV
IASMVLHATS KLENTMKNVR RLLKPGGYLL MLETTSNSPS RIGFTMGGLP GWWLGADDGR
ALSPCVPSAK WDEILRNTGF GGVDSITPEL DPLPCPLSVI ASQAVDNRVS ALRKPLQSPT
ITPLPQNLFV LGGTTLLTAQ LARGVVELLR GRYNRVTVVD HLENINTLDL PPMSTVLSLT
DLDEPVFMSM TTKRLESLKG LFDQSRNVLW LTTGCLGKDP YANMIVGFGR TLVLEMSHIR
LQFLDVDIPD SLEPQALADV LLRLQITGQW ETEGTNSDVL WTTEPELALD QRRLMLPRVY
LNKAQNDRYN SSRRPITKQL DSSKSKVGVI HTGDSYTLRE WNMPNHAQNS HGANCVDINV
RHSLLSSIKI STGASLYLSI GSTLDSNKLV LALSETQTSA VSTPEAWTTP CDIAENQQQH
FLLSVAHNLV AQSILALTDA DETILLNEPG DSFARVTTQR AAEKNLHVAF ATTSAERGSP
WVLIRPSTSK RLVKSMLPDH VSVFMDMSST SDSEEAVGHL VSACLSPACR IVKSSVIFSP
SAIVLPKFST EQIARQLKHA SQHAEIPKSQ ELIPPKEETL LLTDFPKSLS STSRFSLINW
THQAPAQVNL EPIDSKPMFS KDKTYLLFGL TGGLGQSLTQ WMVHHGARFI VLTSRKPSVE
AQWLRDLEAL GATVQVFQND ITDEQSVRNL CDEVRKTFPP IAGIANGAMV LDDTPILNMT
IEKLDKVLAP KVKGSIYLDK LFANDDLEFF ILFSSLACVL GNKGQSNYTT ANSFMVSLAS
QRRNRGLAAS VINIGATVGN GYLTRERSQE LQDYLRKAGF MWMSERDFQQ VFAEGVVAGR
VDSGQSGEVV SGLRVTNDAE EKTIWYNNPK FQHCIIRQSV DETNSEKAKP IVPLKTELLH
ATNKEEIERI LKDSIVLKLR TALLLSSDSA DMMDKNADDL GIDSLVSVSL RSWFLKELHI
DMPVMKILGG STIGQLLSFA VVKLPVDLTP NLNASISSPK SKIHSTDSAP TVKESDVRET
SETYSKVESS SSSSSVSLIQ KESSETGSFT PISPSSSSFS MATPSDKPRS TKRFFKRTHK
MSFGQSRFWF LTSFLADKTT FNVTCSIHVT GPLIVNQFAN AVKSIGQRHE GLRTCFFDDE
DQGPMQGILE NSLLHLEQKT VEETQVVIEF ARMKAHVYDL EHGETMKILL LSESTASHHL
IIGYHHINMD GVSLMVLLSD LERAYSGKPL ASDILQYPEF SEKQRQQHTL GNFENDIIFW
KREFNELPPT LPILSLSTVT TRRVIADYSS NKAEVRISAA LSQSVRKICR EAKATPFHFY
LAVFQILLTR FSGVDDICIG VADAGRSDSG AFESIGHYLN VVPLRSKLQR SQSFSSILAN
AKAKAYAALA NANVPIDVLL NELGVVRSTT NSPLFQAFID YRNVPETQTF GNCKLEGQEY
SVGRTAYDIL LDIVDNSAGE SLLSIVVQQD LYTNGDADIL MKAFINLIEV FAVDPQVGME
APSLYSLVDV EDAIKLGTGP SLKSTWEETL PHRIDSVGRK AGSQVAVKDG LGHKLTYTEL
MKRTNTIASE LSGANIFQQP SPRVAVFQEP TVDWVCSVLA IMRLGATYVP LDLRAPLPRL
ATIVKDCHPQ ALLFHNATSD YINKLDLLDT AAINISHLNS RDVEVSNCAN PDSPAVILYT
SGSTGVPKGI CLHHRAIRNQ IEGFSERWEI TSDIVLQQSA FSFDISLWEM FTALANSGTV
FIVSKASRGD PVALSKIIWD ESITLTIGVT SEYITWLRYG EAKYLQQSSW RLMLCGGEPF
SDILNSELKA LGKPDLRAVN VYGPTEVSFF SNELEVLYKG KGDDLKLPMP VGPAGSNYSI
YILDENLDPV PAGVPGEIYI GGASIATQYI NDKALSSHRF LDNKFASPDW LLRGWKTMHR
SGDWGRLRKE DGALMFEGRI VGDTQIKLRG LRIELRDVES TILSQATGVL EDVVVSVRGD
PQFLVAHVVF RGDYHSTEET RDKYLKRLVS SLPLPQYMCP AMAVTLKTML LNNHSKKDRR
AISDLPLPEK HDRMELDSSH ALTPTETRLK DIWEVVLTKH ILVSHTINED SDFFHSGGNS
MILMALQSSI KQHFSVSLPL VKLFEESTLR RMASCIESGS VQQQASLDIN WKQEIELDAN
TLTAPAYREK AQPHEPRVVL LTGSTGFLGK AMLRQLVEQE SIQKIYCIAV RGEQRFSEFP
SKKIKVYAGD LTLPRLGLSL KDAEAVFNEV DTIIHNGADV SFLKTYSTLK AANLTSTVEL
ANLGLRGSQP QFHYVSSAGV AQLTGKEVID ESSVVQYHPP TDGSNGYSAS KWASEAYLER
VHQHSGLPVF IHRPSSIIGE DAPELDIMHN LLRYSRKMKA VPDLSSWRGW FDFIPVDDVA
SGILKATSLH RSLPSPVLKY IHQSGQIEVP IGDFKTFLEN ESKDEFEMFS SDDWIRRAQE
SGLHELVATY MSQAASVPVV LPRMARSDV
//
