ID S3D6C1_GLAL2 Unreviewed; 738 AA.
AC S3D6C1;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=Long-chain-alcohol oxidase {ECO:0000256|ARBA:ARBA00013125, ECO:0000256|PIRNR:PIRNR028937};
DE EC=1.1.3.20 {ECO:0000256|ARBA:ARBA00013125, ECO:0000256|PIRNR:PIRNR028937};
GN ORFNames=GLAREA_04397 {ECO:0000313|EMBL:EPE27606.1};
OS Glarea lozoyensis (strain ATCC 20868 / MF5171).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Helotiales; Helotiaceae; Glarea.
OX NCBI_TaxID=1116229 {ECO:0000313|EMBL:EPE27606.1, ECO:0000313|Proteomes:UP000016922};
RN [1] {ECO:0000313|EMBL:EPE27606.1, ECO:0000313|Proteomes:UP000016922}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 20868 / MF5171 {ECO:0000313|Proteomes:UP000016922};
RX PubMed=23688303; DOI=10.1186/1471-2164-14-339;
RA Chen L., Yue Q., Zhang X., Xiang M., Wang C., Li S., Che Y.,
RA Ortiz-Lopez F.J., Bills G.F., Liu X., An Z.;
RT "Genomics-driven discovery of the pneumocandin biosynthetic gene cluster in
RT the fungus Glarea lozoyensis.";
RL BMC Genomics 14:339-339(2013).
CC -!- FUNCTION: Long-chain fatty alcohol oxidase involved in the omega-
CC oxidation pathway of lipid degradation.
CC {ECO:0000256|ARBA:ARBA00003842}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a long-chain primary fatty alcohol + O2 = a long-chain fatty
CC aldehyde + H2O2; Xref=Rhea:RHEA:22756, ChEBI:CHEBI:15379,
CC ChEBI:CHEBI:16240, ChEBI:CHEBI:17176, ChEBI:CHEBI:77396; EC=1.1.3.20;
CC Evidence={ECO:0000256|ARBA:ARBA00000920,
CC ECO:0000256|PIRNR:PIRNR028937};
CC -!- SIMILARITY: Belongs to the GMC oxidoreductase family.
CC {ECO:0000256|ARBA:ARBA00010790, ECO:0000256|PIRNR:PIRNR028937}.
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DR EMBL; KE145369; EPE27606.1; -; Genomic_DNA.
DR RefSeq; XP_008084965.1; XM_008086774.1.
DR AlphaFoldDB; S3D6C1; -.
DR GeneID; 19463452; -.
DR KEGG; glz:GLAREA_04397; -.
DR eggNOG; ENOG502QSD8; Eukaryota.
DR HOGENOM; CLU_008878_3_1_1; -.
DR OMA; GCPTNAK; -.
DR OrthoDB; 601859at2759; -.
DR Proteomes; UP000016922; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR GO; GO:0046577; F:long-chain-alcohol oxidase activity; IEA:UniProtKB-EC.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR InterPro; IPR003953; FAD-binding_2.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR000172; GMC_OxRdtase_N.
DR InterPro; IPR007867; GMC_OxRtase_C.
DR InterPro; IPR012400; Long_Oxdase.
DR PANTHER; PTHR46056; LONG-CHAIN-ALCOHOL OXIDASE; 1.
DR PANTHER; PTHR46056:SF4; LONG-CHAIN-ALCOHOL OXIDASE; 1.
DR Pfam; PF00890; FAD_binding_2; 1.
DR Pfam; PF05199; GMC_oxred_C; 1.
DR Pfam; PF00732; GMC_oxred_N; 1.
DR PIRSF; PIRSF028937; Lg_Ch_AO; 2.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 3: Inferred from homology;
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|PIRNR:PIRNR028937};
KW Reference proteome {ECO:0000313|Proteomes:UP000016922};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 220..251
FT /note="FAD-dependent oxidoreductase 2 FAD binding"
FT /evidence="ECO:0000259|Pfam:PF00890"
FT DOMAIN 268..493
FT /note="Glucose-methanol-choline oxidoreductase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00732"
FT DOMAIN 574..723
FT /note="Glucose-methanol-choline oxidoreductase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05199"
FT ACT_SITE 670
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR028937-1"
SQ SEQUENCE 738 AA; 80667 MW; F6B4209B3C822363 CRC64;
MAAAEGPPLP IEVTDENVAN PFSDTQWTTL MSIMDTIIPS IQNDSSTDQN AHKSFSAEEF
NTAVNSLRDI LEKEHDIKIY EEYLNRKASD ESKFQNTLKH AFGKLLPESA RKGMAFILST
LDTRVGSMLL TGYTTSFHDQ PIHIREAILE SWRVSYLPTL NLVYKQMMVI AKNVWLNTSP
SFRELVGIPG GPDHVKLEKP FENDFLQFNS GTAPEIVETD VVIVGSGCGG GVCAKNIAEA
GHRVLVVDKA YHIPAAQLPL SEQNGLRKLF EGGAMLTSDD GSIAVAAGSA WGGGGTINWS
ASLQPQEFVR REWSQDKGLE VFESAEFQDC LDTVCKHMGV SSDHIRHNHA NNNLLEGSRK
LGFSAKAVPQ NTGGKEHYCG HCTLGCGSSE KQGPAVAWLP DAVRAGAQMV EGFRVDHVIF
DEDDPTKATG VKGLWTARDD TGEFDSEGRT TREVIVKAKK VIISSGTLWS PIILQNSGLR
NYHIGRNLHL HPVNMLSAIF PTSTRPWEGG ILTSVCTTFE NLDGLGHGAK LETTVMLPSM
FLVGFPWYSG LQFKRNALKF RNMNGFISIA RDRDTGRVYP DPTTGTPRVK YTPSVFDRKH
ILEGVIGLAK IAYIQGAVEI HPFTSAGRPF IRDPNANPGA GITDPHFQNW IKEFREGGNK
PPATSFSSAH QMGTCRMSRT EAEGVVDDKG RVWGCKGLYV ADASVFPSAS GVNPMVTNMA
VAEWISRGVV GEMGKVEV
//