ID   S3D8J0_GLAL2            Unreviewed;       662 AA.
AC   S3D8J0;
DT   18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT   18-SEP-2013, sequence version 1.
DT   27-MAR-2024, entry version 48.
DE   RecName: Full=Probable Xaa-Pro aminopeptidase P {ECO:0000256|ARBA:ARBA00020658};
DE   AltName: Full=Prolidase {ECO:0000256|ARBA:ARBA00032413};
GN   ORFNames=GLAREA_07083 {ECO:0000313|EMBL:EPE34070.1};
OS   Glarea lozoyensis (strain ATCC 20868 / MF5171).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC   Helotiales; Helotiaceae; Glarea.
OX   NCBI_TaxID=1116229 {ECO:0000313|EMBL:EPE34070.1, ECO:0000313|Proteomes:UP000016922};
RN   [1] {ECO:0000313|EMBL:EPE34070.1, ECO:0000313|Proteomes:UP000016922}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 20868 / MF5171 {ECO:0000313|Proteomes:UP000016922};
RX   PubMed=23688303; DOI=10.1186/1471-2164-14-339;
RA   Chen L., Yue Q., Zhang X., Xiang M., Wang C., Li S., Che Y.,
RA   Ortiz-Lopez F.J., Bills G.F., Liu X., An Z.;
RT   "Genomics-driven discovery of the pneumocandin biosynthetic gene cluster in
RT   the fungus Glarea lozoyensis.";
RL   BMC Genomics 14:339-339(2013).
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|ARBA:ARBA00001936};
CC   -!- SIMILARITY: Belongs to the peptidase M24B family.
CC       {ECO:0000256|ARBA:ARBA00008766, ECO:0000256|RuleBase:RU000590}.
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DR   EMBL; KE145357; EPE34070.1; -; Genomic_DNA.
DR   RefSeq; XP_008079222.1; XM_008081031.1.
DR   AlphaFoldDB; S3D8J0; -.
DR   STRING; 1116229.S3D8J0; -.
DR   GeneID; 19466136; -.
DR   KEGG; glz:GLAREA_07083; -.
DR   eggNOG; KOG2413; Eukaryota.
DR   HOGENOM; CLU_011781_2_3_1; -.
DR   OMA; EPGMILS; -.
DR   OrthoDB; 869at2759; -.
DR   Proteomes; UP000016922; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0070006; F:metalloaminopeptidase activity; IEA:InterPro.
DR   CDD; cd01085; APP; 1.
DR   Gene3D; 3.90.230.10; Creatinase/methionine aminopeptidase superfamily; 1.
DR   Gene3D; 3.40.350.10; Creatinase/prolidase N-terminal domain; 2.
DR   InterPro; IPR029149; Creatin/AminoP/Spt16_NTD.
DR   InterPro; IPR036005; Creatinase/aminopeptidase-like.
DR   InterPro; IPR000587; Creatinase_N.
DR   InterPro; IPR000994; Pept_M24.
DR   InterPro; IPR033740; Pept_M24B.
DR   InterPro; IPR032416; Peptidase_M24_C.
DR   InterPro; IPR001131; Peptidase_M24B_aminopep-P_CS.
DR   PANTHER; PTHR43763; XAA-PRO AMINOPEPTIDASE 1; 1.
DR   PANTHER; PTHR43763:SF6; XAA-PRO AMINOPEPTIDASE 1; 1.
DR   Pfam; PF01321; Creatinase_N; 1.
DR   Pfam; PF16189; Creatinase_N_2; 1.
DR   Pfam; PF00557; Peptidase_M24; 1.
DR   Pfam; PF16188; Peptidase_M24_C; 1.
DR   SUPFAM; SSF55920; Creatinase/aminopeptidase; 1.
DR   SUPFAM; SSF53092; Creatinase/prolidase N-terminal domain; 1.
DR   PROSITE; PS00491; PROLINE_PEPTIDASE; 1.
PE   3: Inferred from homology;
KW   Aminopeptidase {ECO:0000313|EMBL:EPE34070.1};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Manganese {ECO:0000256|ARBA:ARBA00023211};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|RuleBase:RU000590}; Protease {ECO:0000313|EMBL:EPE34070.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000016922}.
FT   DOMAIN          54..188
FT                   /note="Creatinase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF01321"
FT   DOMAIN          370..589
FT                   /note="Peptidase M24"
FT                   /evidence="ECO:0000259|Pfam:PF00557"
FT   DOMAIN          600..662
FT                   /note="Peptidase M24 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF16188"
SQ   SEQUENCE   662 AA;  73797 MW;  92B0293CB2825AAD CRC64;
     MQSSRSLGKV FARTQITGLN QPWLQKLQLA VRYNSTATSA DQAAAMEQIN TTERLTRLRE
     LMKQQKLDVY IVPSEDSHAS EYIAPCDGRR EFISGFSGSA GCAVITHELA ALATDGRYFN
     QAAKQLDGNW LLLKQGLQDV PTWQEWSAEQ SEGGKLVSVD PTVISAPDAR KLSEKIKKKG
     GQELVAVEDN LVDIVWGNDR PAKPSEPIKI LAPQFAGKDL KKKLEDLRKE LDKKKSSGFI
     VSMLDEIAWL FNMRGNDIPY NPVFFSYAAI TPTTATLYVN SAKLSSECKT YLTDNGVSMR
     PYHKIFEDSE VLCKSLDTPD NEPEAKIKKF LVSTKTSWAL KRALGGETKV EEVRSPIGDA
     KAVKNDTELE GMRACHVRDG AALTEYFAWL EDQLIVQNVQ LDEVTAADKL EAIRSKQKHF
     VGLSFDTISS TGANAAVIHY KPERGNCSII DPKAIYLCDS GAQYLDGTTD TTRTLHFGEP
     SAFEKKAYTL VLKGNIALDV AVFPKGTSGF ALDTLARQFL WEEGLDYRHG TGHGVGSYLN
     VHEGPIGIGT RIQYSEVPLS PGNVISNEPG YYEDGNFGIR IENIIMVKEV ETNQKFGDKP
     YLGFEHVTMT PYCRKLIDES LLTRKEKHWL NEYHADIHAK TKDYFEPGSL AIKWLERETE
     PL
//