ID S3D909_GLAL2 Unreviewed; 612 AA.
AC S3D909;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=FAD/NAD(P)-binding protein {ECO:0000313|EMBL:EPE28486.1};
GN ORFNames=GLAREA_09607 {ECO:0000313|EMBL:EPE28486.1};
OS Glarea lozoyensis (strain ATCC 20868 / MF5171).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Helotiales; Helotiaceae; Glarea.
OX NCBI_TaxID=1116229 {ECO:0000313|EMBL:EPE28486.1, ECO:0000313|Proteomes:UP000016922};
RN [1] {ECO:0000313|EMBL:EPE28486.1, ECO:0000313|Proteomes:UP000016922}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 20868 / MF5171 {ECO:0000313|Proteomes:UP000016922};
RX PubMed=23688303; DOI=10.1186/1471-2164-14-339;
RA Chen L., Yue Q., Zhang X., Xiang M., Wang C., Li S., Che Y.,
RA Ortiz-Lopez F.J., Bills G.F., Liu X., An Z.;
RT "Genomics-driven discovery of the pneumocandin biosynthetic gene cluster in
RT the fungus Glarea lozoyensis.";
RL BMC Genomics 14:339-339(2013).
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974,
CC ECO:0000256|PIRSR:PIRSR000137-2};
CC -!- SIMILARITY: Belongs to the GMC oxidoreductase family.
CC {ECO:0000256|ARBA:ARBA00010790}.
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DR EMBL; KE145368; EPE28486.1; -; Genomic_DNA.
DR RefSeq; XP_008084394.1; XM_008086203.1.
DR AlphaFoldDB; S3D909; -.
DR GeneID; 19468654; -.
DR KEGG; glz:GLAREA_09607; -.
DR eggNOG; KOG1238; Eukaryota.
DR HOGENOM; CLU_002865_7_2_1; -.
DR OMA; NYPWIHI; -.
DR OrthoDB; 3382025at2759; -.
DR Proteomes; UP000016922; Unassembled WGS sequence.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR GO; GO:0016614; F:oxidoreductase activity, acting on CH-OH group of donors; IEA:InterPro.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR Gene3D; 3.30.560.10; Glucose Oxidase, domain 3; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR012132; GMC_OxRdtase.
DR InterPro; IPR000172; GMC_OxRdtase_N.
DR InterPro; IPR007867; GMC_OxRtase_C.
DR PANTHER; PTHR11552:SF147; CHOLINE DEHYDROGENASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11552; GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE; 1.
DR Pfam; PF05199; GMC_oxred_C; 1.
DR Pfam; PF00732; GMC_oxred_N; 1.
DR PIRSF; PIRSF000137; Alcohol_oxidase; 1.
DR SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR PROSITE; PS00624; GMC_OXRED_2; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|ARBA:ARBA00022827, ECO:0000256|PIRSR:PIRSR000137-2};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Reference proteome {ECO:0000313|Proteomes:UP000016922}.
FT DOMAIN 268..282
FT /note="Glucose-methanol-choline oxidoreductase N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS00624"
FT ACT_SITE 514
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000137-1"
FT ACT_SITE 558
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000137-1"
FT BINDING 228
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR000137-2"
SQ SEQUENCE 612 AA; 67266 MW; 867F311517997484 CRC64;
MTTSINTDPQ DTVYDYIVCG GGTAGAVLAA RLAEDENNSV LVIEAGQHNS LLENTIMVGG
WSQNFDTEAD WNITTEPSPG ANGRQVKVSR GKFLGGSSGV NGTLCIRGTK QDYDDWNQPG
WSGDEVFGYM KKAENFHDKK WFDADKEAHG YDGLLDIEPH DLVPISNMIL ESMQDQGLAL
QPDMFTSGNN PHGCGHAPRT HYKGDRTTSA NYFRNKGPNL AIKTDTIVDK VFLEGEAENL
KAVAVKIIEK DGSSKELKAK KEIIISGGAY CSPTILMRSG LGPKSELEKH GIDCKIDLPG
VGQNLMDHLI VFIFYQTTKP NITNDHLLYK PDALGEAYRQ WKEEKQGPLS TFPFGAFAYA
RLDERLKSEP LWKNAPRKEG CDPMGLKPNQ PNIEFFSTEC YGGPKQFDQY PDGEKTHAFS
LIAELFSPKS RGSVTLKSAD PKDNPVVDHN YLSDELDVLV LSEACKFANE IITMGKGTKD
IVEGSWPKDL THHTHTKRED WVPYVKDNAT TCYHPGGTCK MGPADDPMAV LDHELRVRGV
KGLRVADTSI MPLLNQGHTQ MPAYAIGEKA ADLIRGKFLK LASVDSANIK MHEASAITGR
EEVNGNGTVV LN
//
