ID S3DA25_GLAL2 Unreviewed; 1350 AA.
AC S3DA25;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=p-loop containing nucleoside triphosphate hydrolase {ECO:0000313|EMBL:EPE35282.1};
GN ORFNames=GLAREA_10981 {ECO:0000313|EMBL:EPE35282.1};
OS Glarea lozoyensis (strain ATCC 20868 / MF5171).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Helotiales; Helotiaceae; Glarea.
OX NCBI_TaxID=1116229 {ECO:0000313|EMBL:EPE35282.1, ECO:0000313|Proteomes:UP000016922};
RN [1] {ECO:0000313|EMBL:EPE35282.1, ECO:0000313|Proteomes:UP000016922}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 20868 / MF5171 {ECO:0000313|Proteomes:UP000016922};
RX PubMed=23688303; DOI=10.1186/1471-2164-14-339;
RA Chen L., Yue Q., Zhang X., Xiang M., Wang C., Li S., Che Y.,
RA Ortiz-Lopez F.J., Bills G.F., Liu X., An Z.;
RT "Genomics-driven discovery of the pneumocandin biosynthetic gene cluster in
RT the fungus Glarea lozoyensis.";
RL BMC Genomics 14:339-339(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCB family.
CC Multidrug resistance exporter (TC 3.A.1.201) subfamily.
CC {ECO:0000256|ARBA:ARBA00007577}.
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DR EMBL; KE145354; EPE35282.1; -; Genomic_DNA.
DR RefSeq; XP_008077361.1; XM_008079170.1.
DR GeneID; 19470023; -.
DR KEGG; glz:GLAREA_10981; -.
DR eggNOG; KOG0055; Eukaryota.
DR HOGENOM; CLU_000604_17_2_1; -.
DR OMA; GFGQEEQ; -.
DR OrthoDB; 1067095at2759; -.
DR Proteomes; UP000016922; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd18577; ABC_6TM_Pgp_ABCB1_D1_like; 1.
DR CDD; cd18578; ABC_6TM_Pgp_ABCB1_D2_like; 1.
DR CDD; cd03249; ABC_MTABC3_MDL1_MDL2; 2.
DR Gene3D; 1.20.1560.10; ABC transporter type 1, transmembrane domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011527; ABC1_TM_dom.
DR InterPro; IPR036640; ABC1_TM_sf.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR039421; Type_1_exporter.
DR PANTHER; PTHR24221; ATP-BINDING CASSETTE SUB-FAMILY B; 1.
DR PANTHER; PTHR24221:SF503; LP14331P; 1.
DR Pfam; PF00664; ABC_membrane; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF90123; ABC transporter transmembrane region; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS50929; ABC_TM1F; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Hydrolase {ECO:0000313|EMBL:EPE35282.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000016922};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 103..127
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 157..178
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 230..249
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 255..277
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 333..354
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 366..385
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 767..792
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 827..849
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 895..917
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 923..948
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1009..1029
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1041..1065
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 107..397
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000259|PROSITE:PS50929"
FT DOMAIN 432..677
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 771..1070
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000259|PROSITE:PS50929"
FT DOMAIN 1105..1343
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT REGION 1..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 23..53
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1350 AA; 147421 MW; 9ECB80D1EAA4C33D CRC64;
MGADFSEKPD RRSTGASSHG DSTSEHDSTR KEKAETSRLS SDRKAQSIAK ADSHVVQVKD
KGEDDIYAHL PPAEAQILKN QVELPVVKAG VKILYRYATV NDYLIIAISA ICSIAAGAAL
PLMTIIFGNL AGEFNSYFAG TTSRADFNDT INHMVLYFIY IGIAEFVTIY VSTVGFIYTG
EHISGKIRWH YLEACLRQNI GFFDKLGSGE ITTRITADTN LVQDGISEKV GLTLNAVATF
VTAFVIGFIK SWKLTLILSS TVVAITVSMG LGSTFIVKYS KQSLGSYALG GSIAEEVISS
IRNAVAFGTQ DKLARQYDVH LAKAEKYGHR VKFVLAIMIG GMFCVIYLNY GLAFWMGSRF
LVNNEITLSA ILTILMSIMI GAFAFGNVAP NAQAFTTAIS AAAKIYNTID RVSPLDPTSE
KGEIIPEVKG TIELRNIKHI YPSRPEVTVM QDVSLVIPAG KKTALVGASG SGKSTIVGLV
ERFYDPVGGQ VFLDGKDVST LNLRWLRQQI SLVSQEPTLF GTTIYENIRH GLIGTKHENE
SADQQKELVL EAAKMANAHD FITALPEKYE TNVGERGFLL SGGQKQRIAI ARAMVSNPKI
LLLDEATSAL DTKSEGVVQA ALEVAAAGRT TITIAHRLST IKDADNIVVM TQGRIVEQGT
HNELLATRGA YYSLIEAQKI AAKEEMSAEE EAEIDHEDDK LVRKMTSKSG DFMEDPDDKN
IANKLNRTQS EKSQSSVAMQ GRSENKIPEP SLWTLIKLIA SFNKKEMWWM LLGLSFSIIC
GGGNPVQAVF FAKEIISLSY PLTDPRTGAE IPGAAHKIRS DVNFWSLMYL MLAIVQLIAY
CGQGLAFAFC SEKLIHRVRD RAFRTMLRQD IAFFDKDENT AGALTSFLST QTTHVSGLSG
VTLGTLLSVI TTLVAAIAVS TAIAWKLALV CVATIPVLLG CGFFRFWLLA QFQQRAKKSY
EKSASFACEA TSAIRTVASL TRENDVLQQY VDSLEAQEKR SLNSVLKSSL LYAASQSLMF
ACVALGFWYG GNRIADHEYS MFQFFVCFSA VIFGAQSAGT IFSFAPDMGK AKQAAAELKI
LFDRQPTIDT WSEDGASLQN VEGHIEFRDV HFRYPTRPEQ PVLRGINLSV KPGQYIALVG
ASGCGKSTTI ALLERFYDPL VGGIYIDGKE ISSLNINDYR SYIALVSQEP TLYQGTIREN
VLLGADRQDV PDSAIEHACR EANIYDFIMS LPDGFSTVVG SKGSMLSGGQ KQRVAIARAL
LRDPKVLLLD EATSALDSES EHVVQAALDK AAKGRTTIAV AHRLSTIQKA DIIYVFDQGR
IVEQGTHMEL MSKGGRYSEL VNLQSLGKTG
//
