ID S3DA90_GLAL2 Unreviewed; 520 AA.
AC S3DA90;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=Phosphotransferase {ECO:0000256|RuleBase:RU362007};
DE EC=2.7.1.- {ECO:0000256|RuleBase:RU362007};
GN ORFNames=GLAREA_00039 {ECO:0000313|EMBL:EPE28881.1};
OS Glarea lozoyensis (strain ATCC 20868 / MF5171).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Helotiales; Helotiaceae; Glarea.
OX NCBI_TaxID=1116229 {ECO:0000313|EMBL:EPE28881.1, ECO:0000313|Proteomes:UP000016922};
RN [1] {ECO:0000313|EMBL:EPE28881.1, ECO:0000313|Proteomes:UP000016922}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 20868 / MF5171 {ECO:0000313|Proteomes:UP000016922};
RX PubMed=23688303; DOI=10.1186/1471-2164-14-339;
RA Chen L., Yue Q., Zhang X., Xiang M., Wang C., Li S., Che Y.,
RA Ortiz-Lopez F.J., Bills G.F., Liu X., An Z.;
RT "Genomics-driven discovery of the pneumocandin biosynthetic gene cluster in
RT the fungus Glarea lozoyensis.";
RL BMC Genomics 14:339-339(2013).
CC -!- SIMILARITY: Belongs to the hexokinase family.
CC {ECO:0000256|ARBA:ARBA00009225, ECO:0000256|RuleBase:RU362007}.
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DR EMBL; KE145367; EPE28881.1; -; Genomic_DNA.
DR RefSeq; XP_008082990.1; XM_008084799.1.
DR AlphaFoldDB; S3DA90; -.
DR STRING; 1116229.S3DA90; -.
DR GeneID; 19459099; -.
DR KEGG; glz:GLAREA_00039; -.
DR eggNOG; KOG1369; Eukaryota.
DR HOGENOM; CLU_014393_4_1_1; -.
DR OMA; FPVEQTS; -.
DR OrthoDB; 5481886at2759; -.
DR UniPathway; UPA00109; UER00180.
DR Proteomes; UP000016922; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0005536; F:glucose binding; IEA:InterPro.
DR GO; GO:0004396; F:hexokinase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0001678; P:intracellular glucose homeostasis; IEA:InterPro.
DR Gene3D; 3.30.420.40; -; 1.
DR Gene3D; 3.40.367.20; -; 1.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR001312; Hexokinase.
DR InterPro; IPR022673; Hexokinase_C.
DR InterPro; IPR022672; Hexokinase_N.
DR PANTHER; PTHR19443; HEXOKINASE; 1.
DR PANTHER; PTHR19443:SF24; HEXOKINASE YLR446W-RELATED; 1.
DR Pfam; PF00349; Hexokinase_1; 1.
DR Pfam; PF03727; Hexokinase_2; 1.
DR PRINTS; PR00475; HEXOKINASE.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 2.
DR PROSITE; PS51748; HEXOKINASE_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU362007};
KW Glycolysis {ECO:0000256|RuleBase:RU362007};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|RuleBase:RU362007};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU362007};
KW Reference proteome {ECO:0000313|Proteomes:UP000016922};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU362007}.
FT DOMAIN 59..259
FT /note="Hexokinase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00349"
FT DOMAIN 266..517
FT /note="Hexokinase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03727"
SQ SEQUENCE 520 AA; 56827 MW; AA8BCD5CB95B348D CRC64;
MYKVRQAFYA AFIRSLLRTK SVLQTILNIW LSPSVIKGDK VNKEGGAAER NNKIEEFLKN
IEDEFRKSKE TPNLVALSNG LREQFGKSLL DNPLCMLPSY NHQLPHGNER GTYLALDVGG
STFRIALIEL FGRKSEGAGS VILKRDTFKI TSDVKQLKGV LFFDWMAKRI AETLSGQNEG
NNMSKAPLSM GMSWSFPIEQ TSLRSGLLQE MGKNFLAAHG LIGRDLGDII QESCSRIGLN
VQLDAIVNDS SATLLSKAYL DQTTRFALIL GTGVNAAVHL PVHMFSQEKF GVRPASWHES
AKHVIVNTEL SMFGSGILPY TRWDRALLAT HSRPDFQPLE HFVSGGYLGE ISRLILVEGI
ETAGLMGGIV PPSLMERYSL ETETLSHIES DTSATLSNAV QLFTSKHPSS CPPTHSDILA
IRQIASHVAY RASGVVAAGI HGLWQMRNIA EGIQADKLSH TLVAYNGSVM ENYPDFRKSC
QSQIDSLVQS SGGQPGLVEL MYAEESSLLG AAVAVACIAG
//
